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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ay2CXPAromatic-amino-acid aminotransferase2.6.1.57

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ay2CXPAromatic-amino-acid aminotransferase2.6.1.571.000
2ay5IOPAromatic-amino-acid aminotransferase2.6.1.570.671
2ay95PVAromatic-amino-acid aminotransferase2.6.1.570.590
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.572
2ay84TBAromatic-amino-acid aminotransferase2.6.1.570.548
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.537
1x28PGUAspartate aminotransferase2.6.1.10.520
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.513
1maqPGUAspartate aminotransferase, mitochondrial2.6.1.10.499
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.494
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.493
1cq6PY4Aspartate aminotransferase2.6.1.10.491
1cq8PY6Aspartate aminotransferase2.6.1.10.491
3rtnRTNBeta-secretase 13.4.23.460.489
1cq7PY5Aspartate aminotransferase2.6.1.10.486
3b1dPLSBetaC-S lyase/0.482
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.480
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.479
1arhPPDAspartate aminotransferase2.6.1.10.479
4emyPLPAminotransferase class I and II/0.478
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.477
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.477
3ei8PL5LL-diaminopimelate aminotransferase, chloroplastic/0.477
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.475
3qpg3QPAspartate aminotransferase2.6.1.10.475
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.474
3dr4G4MGDP-perosamine synthase/0.474
3kt3TYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.474
4rkdKETAminotransferase/0.473
1touB1VFatty acid-binding protein, adipocyte/0.469
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.466
3fr5I4AFatty acid-binding protein, adipocyte/0.465
3hdyGDUUDP-galactopyranose mutase/0.465
1je1GMPPurine nucleoside phosphorylase/0.464
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.464
1toiHCIAspartate aminotransferase2.6.1.10.464
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.463
4dbc3QPAspartate aminotransferase2.6.1.10.463
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.462
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.461
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.461
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.460
3fr4F8AFatty acid-binding protein, adipocyte/0.458
1ttm667Carbonic anhydrase 24.2.1.10.457
1ascNPLAspartate aminotransferase2.6.1.10.456
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.456
2fq6P3FCystathionine beta-lyase MetC4.4.1.80.455
3rsv3RSBeta-secretase 13.4.23.460.455
4bftZVTPantothenate kinase2.7.1.330.455
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
1x1bSAHC-20 methyltransferase/0.454
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.454
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.453
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.453
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.452
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.452
1n1dC2GGlycerol-3-phosphate cytidylyltransferase2.7.7.390.451
1x1aSAMC-20 methyltransferase/0.451
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.451
2whqHI6Acetylcholinesterase3.1.1.70.451
3dr7GPDGDP-perosamine synthase/0.451
4uy6SAHHistidine N-alpha-methyltransferase/0.451
3iu8T03Methionine aminopeptidase 2/0.450
2a9z26AAdenosine kinase2.7.1.200.449
4jxxATPGlutamine--tRNA ligase6.1.1.180.449
4to0DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.449
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.448
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.448
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
4m2bUPGUDP-glucose pyrophosphorylase/0.448
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.448
1c7oPPGHemolysin/0.447
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.447
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3h3qH13Collagen type IV alpha-3-binding protein/0.447
1ydaAZMCarbonic anhydrase 24.2.1.10.446
2pb1NFGGlucan 1,3-beta-glucosidase/0.446
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.446
3fvlBHKCarboxypeptidase A13.4.17.10.446
3igpDT7Carbonic anhydrase 24.2.1.10.446
4b4w9L9Bifunctional protein FolD/0.446
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.445
2g1n1IGRenin3.4.23.150.445
2g8yNADHydroxycarboxylate dehydrogenase B/0.445
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2wjoQUDBeta-secretase 13.4.23.460.444
2an9GDPGuanylate kinase2.7.4.80.443
1rzuADPGlycogen synthase 12.4.1.210.442
3elePLPAminotransferase/0.442
3ogwIMNLactoperoxidase1.11.1.70.442
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.442
3zxiTYATyrosine--tRNA ligase, mitochondrial6.1.1.10.442
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
4xbjIN5Alanine racemase, biosynthetic/0.442
4u140HKMuscarinic acetylcholine receptor M3/0.442
1ivsVAAValine--tRNA ligase6.1.1.90.441
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.441
1argPPDAspartate aminotransferase2.6.1.10.440
1vbmYSATyrosine--tRNA ligase6.1.1.10.440
3bl7DD1m7GpppX diphosphatase3.6.1.590.440
4rvfTYDD-mycarose 3-C-methyltransferase/0.440