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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2af3COAPhosphate acetyltransferase2.3.1.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2af3COAPhosphate acetyltransferase2.3.1.81.000
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.493
1xe55FEPlasmepsin-23.4.23.390.490
1ma0NADAlcohol dehydrogenase class-31.1.1.10.485
2gv8NDPThiol-specific monooxygenase1.14.130.485
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.484
1lbcCYZGlutamate receptor 2/0.482
1xe65FPPlasmepsin-23.4.23.390.477
2owgSAHDiphthine synthase/0.475
3pdqKC6Lysine-specific demethylase 4A1.14.110.474
2e7rSAHDiphthine synthase/0.473
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.473
1mj9COAHistone acetyltransferase ESA1/0.472
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.472
2ejkSAHDiphthine synthase/0.471
3kb1ADPIron-sulfur cluster carrier protein/0.471
1tqf32PBeta-secretase 13.4.23.460.470
2ou2ACOHistone acetyltransferase KAT5/0.470
4xguADPPutative pachytene checkpoint protein 2/0.470
3imgBZ2Pantothenate synthetase6.3.2.10.468
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.468
2e4nSAHDiphthine synthase/0.467
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.466
1w6hTITPlasmepsin-23.4.23.390.465
1wngSAHDiphthine synthase/0.465
2e17SAHDiphthine synthase/0.465
2g226IGRenin3.4.23.150.465
3p62FMNPentaerythritol tetranitrate reductase/0.465
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
2pchSAHDiphthine synthase/0.464
5a9sNAPPutative dehydrogenase/0.464
2dv7SAHDiphthine synthase/0.463
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.463
2huvSAHDiphthine synthase/0.463
4m83ERYOleandomycin glycosyltransferase2.4.10.463
1e79ATPATP synthase subunit alpha, mitochondrial/0.462
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.462
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.462
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.462
5d3qGDPDynamin-13.6.5.50.462
1c6yMK1Protease/0.461
2eh4SAHDiphthine synthase/0.461
2ehlSAHDiphthine synthase/0.461
4df2FMNNADPH dehydrogenase/0.461
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2g1o2IGRenin3.4.23.150.460
2uxoTACHTH-type transcriptional regulator TtgR/0.460
3f03FMNPentaerythritol tetranitrate reductase/0.460
3ixp834Ecdysone receptor/0.460
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.460
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
2dv3SAHDiphthine synthase/0.459
2owkSAHDiphthine synthase/0.459
1culFOKAdenylate cyclase type 2/0.458
1culFOKAdenylate cyclase type 5/0.458
2bn4FMNNADPH--cytochrome P450 reductase/0.458
2e07SAHDiphthine synthase/0.458
2pcaSAHDiphthine synthase/0.458
3qt62P0Mevalonate diphosphate decarboxylase/0.458
1dr3TAPDihydrofolate reductase1.5.1.30.457
2aa3AP0L-lactate dehydrogenase/0.457
2hutSAHDiphthine synthase/0.457
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.457
3tjzGNPADP-ribosylation factor 1/0.457
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.456
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2is0I03Beta-secretase 13.4.23.460.456
2pcgSAHDiphthine synthase/0.456
2xfsJ01Uncharacterized protein/0.456
1h60STRPentaerythritol tetranitrate reductase/0.455
1kp3ATPArgininosuccinate synthase6.3.4.50.455
2eleSAHDiphthine synthase/0.455
2emrSAHDiphthine synthase/0.455
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.455
2p9dSAHDiphthine synthase/0.455
2pciSAHDiphthine synthase/0.455
2qiqCYVReplicase polyprotein 1ab/0.455
2y0mACOHistone acetyltransferase KAT8/0.455
3hl0NADMaleylacetate reductase/0.455
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.455
2huxSAHDiphthine synthase/0.454
3a3gDLZLumazine protein/0.454
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.454
4asuADPATP synthase subunit alpha, mitochondrial/0.454
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
1u3dFADCryptochrome-1/0.453
2dxxSAHDiphthine synthase/0.453
2eniSAHDiphthine synthase/0.453
2huqSAHDiphthine synthase/0.453
2p6dSAHDiphthine synthase/0.453
2pb4SAHDiphthine synthase/0.453
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
1kkq471Peroxisome proliferator-activated receptor alpha/0.452
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.452
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.452
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.452
1me6IVSPlasmepsin-23.4.23.390.451
1mp0NADAlcohol dehydrogenase class-31.1.1.10.451
2il2LIXRenin3.4.23.150.451
3ig6438Urokinase-type plasminogen activator3.4.21.730.451
3vqsJT1Genome polyprotein/0.451
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.451
1g63FMNEpidermin decarboxylase4.1.10.450
1h50FMNPentaerythritol tetranitrate reductase/0.450
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.450
2abbFMNPentaerythritol tetranitrate reductase/0.450
2el0SAHDiphthine synthase/0.450
2he5NDPAldo-keto reductase family 1 member C211.1.10.450
2hxzH7JCathepsin S3.4.22.270.450
4o1mNADEnoyl-acyl carrier reductase/0.450
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.450
1bwsNDPGDP-L-fucose synthase/0.449
1cdoNADAlcohol dehydrogenase 11.1.1.10.449
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.449
1udaUFGUDP-glucose 4-epimerase5.1.3.20.449
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2b7aIZATyrosine-protein kinase JAK2/0.449
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.449
2pcmSAHDiphthine synthase/0.449
3bbrBHYGlutamate receptor 2/0.449
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.449
1e3eNAIAlcohol dehydrogenase 41.1.1.10.448
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.448
2v7qATPATP synthase subunit alpha, mitochondrial/0.448
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.448
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
3kgcLY7Glutamate receptor 2/0.448
3omuIBDHeat shock protein 83/0.448
3s1dZIRCytokinin dehydrogenase 11.5.99.120.448
3v3m0ENReplicase polyprotein 1a3.4.19.120.448
4b1rITCTetracycline repressor protein class D/0.448
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.448
4qxq1YEStimulator of interferon genes protein/0.448
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.448
1icqFMN12-oxophytodienoate reductase 11.3.1.420.447
2e8hSAHDiphthine synthase/0.447
2ikuLIYRenin3.4.23.150.447
2iyfERYOleandomycin glycosyltransferase2.4.10.447
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
2xhd7T9Glutamate receptor 2/0.447
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.447
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.447
3to6LYS_CMCHistone acetyltransferase ESA1/0.447
4bfzZVZPantothenate kinase2.7.1.330.447
4du82P0Mevalonate diphosphate decarboxylase/0.447
4qxr1YEStimulator of interferon genes protein/0.447
1h51FMNPentaerythritol tetranitrate reductase/0.446
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.446
2ejjSAHDiphthine synthase/0.446
2givACOHistone acetyltransferase KAT8/0.446
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.446
3il1B5DGlutamate receptor 2/0.446
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.446
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.446
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.446
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.446
3u9eCOALmo1369 protein/0.446
4j0v1H7Beta-secretase 13.4.23.460.446
5kwvANPPantothenate synthetase/0.446
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
2a94AP0L-lactate dehydrogenase1.1.1.270.445
2e08SAHDiphthine synthase/0.445
2egsSAHDiphthine synthase/0.445
2ejzSAHDiphthine synthase/0.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
2pckSAHDiphthine synthase/0.445
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4q73FADBifunctional protein PutA/0.445
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.445
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2dv4SAHDiphthine synthase/0.444
2dvlFADAcyl-CoA dehydrogenase/0.444
2egbSAHDiphthine synthase/0.444
2gtbAZPOrf1ab polyprotein/0.444
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.444
2zvcSAHPrecorrin-3 C17-methyltransferase/0.444
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
3w233RODihydroorotate dehydrogenase (fumarate)1.3.98.10.444
4a8v2ANMajor pollen allergen Bet v 1-J/0.444
4eu4COASuccinyl-CoA:acetate CoA-transferase/0.444
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.444
4wzhFMNDihydroorotate dehydrogenase (fumarate)/0.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.443
2ed5SAHDiphthine synthase/0.443
2eglSAHDiphthine synthase/0.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.443
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
3triNAPPyrroline-5-carboxylate reductase/0.443
3zhyFM61-deoxy-D-xylulose 5-phosphate reductoisomerase/0.443
4b4vL34Bifunctional protein FolD/0.443
4fk8FADFerredoxin--NADP reductase/0.443
4kgkGTPUncharacterized protein/0.443
5c41ACPRibokinase/0.443
1rfuADPPyridoxal kinase2.7.1.350.442
2bjfDXCCholoylglycine hydrolase3.5.1.240.442
2dsgSAHDiphthine synthase/0.442
2emuSAHDiphthine synthase/0.442
2hr8SAHDiphthine synthase/0.442
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.442
2q7vFADThioredoxin reductase/0.442
2z6rSAHDiphthine synthase/0.442
3ijoB4DGlutamate receptor 2/0.442
3lqfNADGalactitol dehydrogenase/0.442
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.442
4a862ANMajor pollen allergen Bet v 1-A/0.442
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4bfxZVXPantothenate kinase2.7.1.330.442
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.442
4ipw1G7Mycocyclosin synthase1.14.21.90.442
4k37SAMAnaerobic sulfatase-maturating enzyme1.8.980.442
4k6fNAPPutative Acetoacetyl-CoA reductase/0.442
5a0yCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.442
5a0yCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.442
1icpFMN12-oxophytodienoate reductase 11.3.1.420.441
1xddAAYIntegrin alpha-L/0.441
1xvaSAMGlycine N-methyltransferase2.1.1.200.441
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.441
2b8l5HABeta-secretase 13.4.23.460.441
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
2hldANPATP synthase subunit alpha, mitochondrial/0.441
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.441
2oapANPType II secretion system protein (GspE-2)/0.441
2p6iSAHDiphthine synthase/0.441
3a3bRBFLumazine protein/0.441
3gobHXXDdmC/0.441
5czySAMEukaryotic huntingtin interacting protein B/0.441
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.440
1o6zNADMalate dehydrogenase/0.440
1pjcNADAlanine dehydrogenase/0.440
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.440
1t85CAMCamphor 5-monooxygenase1.14.15.10.440
2dshSAHDiphthine synthase/0.440
2e8rSAHDiphthine synthase/0.440
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.440
2vhtATPNTPase P4/0.440
3d91REMRenin3.4.23.150.440
3enkUPGUDP-glucose 4-epimerase/0.440
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
4b2gV1NUncharacterized protein/0.440
4emtC2EStimulator of interferon genes protein/0.440
4i1iNADMalate dehydrogenase/0.440
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.440