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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2acqNAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2acqNAPAldose reductase1.1.1.211.000
1x96NAPAldose reductase1.1.1.210.666
2iq0NAPAldose reductase1.1.1.210.659
1z8aNAPAldose reductase1.1.1.210.642
1x98NAPAldose reductase1.1.1.210.631
2pf8NDPAldose reductase1.1.1.210.616
3q65NAPAldose reductase1.1.1.210.612
1az2NAPAldose reductase1.1.1.210.607
2j8tNAPAldose reductase1.1.1.210.600
3q67NAPAldose reductase1.1.1.210.597
2pfhNDPAldose reductase1.1.1.210.591
1ah4NAPAldose reductase1.1.1.210.590
2acsNAPAldose reductase1.1.1.210.590
3v36NAPAldose reductase1.1.1.210.586
2pevNDPAldose reductase1.1.1.210.569
2acuNAPAldose reductase1.1.1.210.564
1adsNAPAldose reductase1.1.1.210.555
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.549
3o3rNAPAldose reductase-related protein 11.1.1.210.533
3qkzNAPAldose reductase-related protein 11.1.1.210.529
3h7rNAPAldo-keto reductase family 4 member C8/0.526
2hejNDPAldo-keto reductase family 1 member C211.1.10.515
4g5dNDPProstaglandin F synthase1.1.1.1880.510
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.507
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.487
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.486
1zgdNAPChalcone reductase/0.485
1c9wNAPAldose reductase-related protein 2/0.482
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.482
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.481
3wczNAPAldo-keto reductase AKR2E4/0.479
4pmjNAPPutative oxidoreductase/0.479
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.478
1s1rNAPAldo-keto reductase family 1 member C3/0.472
1vp5NAPOxidoreductase, aldo/keto reductase family/0.468
1ef3NAPAldose reductase1.1.1.210.467
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.467
4jtqNAPAldo-keto reductase family 1 member C2/0.465
2hdjNDPAldo-keto reductase family 1 member C2/0.457
4xo7NAPAldo-keto reductase family 1 member C2/0.456
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.452
4dz5NAPAldo-keto reductase family 1 member C3/0.452
1lqaNDPProtein tas/0.451
2p5nNDPAldo-keto reductase family 1 member C211.1.10.450
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.447
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.440