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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a41ATPActin, alpha skeletal muscle

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a41ATPActin, alpha skeletal muscle/1.000
4m63ATPActin-5C/0.557
1kxpATPActin, alpha skeletal muscle/0.550
2q36ATPActin, alpha skeletal muscle/0.548
4k42ADPActin, alpha skeletal muscle/0.548
1lotATPActin, alpha skeletal muscle/0.545
4pkiATPActin, alpha skeletal muscle/0.541
1t44ATPActin, alpha skeletal muscle/0.539
1mduATPActin, alpha skeletal muscle/0.538
3m6gATPActin, alpha skeletal muscle/0.536
4pkhADPActin, alpha skeletal muscle/0.536
3mn6ATPActin-5C/0.533
4pkgATPActin, alpha skeletal muscle/0.528
3tu5ATPActin, alpha skeletal muscle/0.524
1c0fATPMajor actin/0.523
1s22ATPActin, alpha skeletal muscle/0.522
3ffkATPActin, alpha skeletal muscle/0.522
4pl8ATPActin, alpha skeletal muscle/0.520
3a5mATPMajor actin/0.519
3a5oATPMajor actin/0.516
1rgiATPActin, alpha skeletal muscle/0.513
3u9dATPActin, alpha skeletal muscle/0.512
4cbxATPActin-2/0.511
1eqyATPActin, alpha skeletal muscle/0.508
1qz5ATPActin, alpha skeletal muscle/0.508
3el2ATPActin-5C/0.507
1nmdATPMajor actin/0.505
1yxqATPActin, alpha skeletal muscle/0.505
4jhdANPActin-5C/0.504
3w3dATPActin, gamma-enteric smooth muscle/0.502
1h1vATPActin, alpha skeletal muscle/0.501
2v51ATPActin, alpha skeletal muscle/0.501
3m1fATPActin, alpha skeletal muscle/0.501
5ce3ATPActin/0.501
4k41ATPActin, alpha skeletal muscle/0.493
3mn7ATPActin-5C/0.492
2p9kATPActin-related protein 2/0.491
1dejATPMajor actin/0.486
3u4lATPActin, cytoplasmic 1/0.482
1ijjATPActin, alpha skeletal muscle/0.480
4rwtANPActin-5C/0.479
3mn9ATPActin-5C/0.474
4ci6ATPActin/0.469
4k43ADPActin, alpha skeletal muscle/0.465
2oanATPActin, cytoplasmic 1/0.464
1nm1ATPMajor actin/0.462
3eksATPActin-5C/0.456
2q97ATPActin, alpha skeletal muscle/0.454
1rfqATPActin, alpha skeletal muscle/0.450