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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zzlTZYMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zzlTZYMitogen-activated protein kinase 14/1.000
3hub469Mitogen-activated protein kinase 14/0.634
3zsh469Mitogen-activated protein kinase 14/0.629
3itzP66Mitogen-activated protein kinase 14/0.624
3fl4FL4Mitogen-activated protein kinase 14/0.611
2yixYIXMitogen-activated protein kinase 14/0.608
3fkoFKOMitogen-activated protein kinase 14/0.608
3fmmXI2Mitogen-activated protein kinase 14/0.598
3fknFKNMitogen-activated protein kinase 14/0.596
3rinI2OMitogen-activated protein kinase 14/0.587
2gfsPQBMitogen-activated protein kinase 14/0.586
1ove358Mitogen-activated protein kinase 14/0.575
3ds6A17Mitogen-activated protein kinase 14/0.564
3bx5304Mitogen-activated protein kinase 14/0.561
1w7h3IPMitogen-activated protein kinase 14/0.544
3e92G6AMitogen-activated protein kinase 14/0.541
3roc29AMitogen-activated protein kinase 14/0.532
1wbwLI4Mitogen-activated protein kinase 14/0.529
2zb1GK4Mitogen-activated protein kinase 14/0.525
3c5uP41Mitogen-activated protein kinase 14/0.520
3gc8B45Mitogen-activated protein kinase 112.7.11.240.518
3gc9B45Mitogen-activated protein kinase 112.7.11.240.517
3s4qNK0Mitogen-activated protein kinase 14/0.514
3hp552PMitogen-activated protein kinase 14/0.513
1bl6SB6Mitogen-activated protein kinase 14/0.510
1ywrLI9Mitogen-activated protein kinase 14/0.510
3mpaSB2Mitogen-activated protein kinase 14/0.510
1ouy094Mitogen-activated protein kinase 14/0.509
3hllI45Mitogen-activated protein kinase 14/0.509
3lfeZ84Mitogen-activated protein kinase 14/0.509
1zyjBI5Mitogen-activated protein kinase 14/0.507
3dt1P40Mitogen-activated protein kinase 14/0.503
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.501
3d7zGK5Mitogen-activated protein kinase 14/0.499
1yqj6NPMitogen-activated protein kinase 14/0.498
3uvqFS8Mitogen-activated protein kinase 14/0.494
3iw5DF3Mitogen-activated protein kinase 14/0.493
3kf7L9GMitogen-activated protein kinase 14/0.493
3hl7I47Mitogen-activated protein kinase 14/0.492
2qd9LGFMitogen-activated protein kinase 14/0.491
2zb0GK3Mitogen-activated protein kinase 14/0.491
3fln3FNMitogen-activated protein kinase 14/0.489
3ha85JZMitogen-activated protein kinase 14/0.489
1ouk084Mitogen-activated protein kinase 14/0.488
3flyFLYMitogen-activated protein kinase 14/0.487
3l8sBFFMitogen-activated protein kinase 14/0.487
3nww3NWMitogen-activated protein kinase 14/0.487
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.485
4ma628EAra h 8 allergen/0.485
3fmn530Mitogen-activated protein kinase 14/0.484
3uibSB2Putative mitogen-activated protein kinase/0.484
1m7qDQOMitogen-activated protein kinase 14/0.480
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.480
2wleCOAPolysialic acid O-acetyltransferase/0.478
3fc152PMitogen-activated protein kinase 14/0.478
3iphG11Mitogen-activated protein kinase 14/0.478
3u8w09JMitogen-activated protein kinase 14/0.477
3flsFLSMitogen-activated protein kinase 14/0.476
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.474
4jvlESTEstrogen sulfotransferase2.8.2.40.474
2ydoADNAdenosine receptor A2a/0.473
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.473
4aa5NQBMitogen-activated protein kinase 14/0.473
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.472
2z3uCRRCytochrome P450/0.471
3iw6PP0Mitogen-activated protein kinase 14/0.470
3iw8HIZMitogen-activated protein kinase 14/0.470
3mvl38PMitogen-activated protein kinase 14/0.470
4lopSB4Mitogen-activated protein kinase 14/0.470
1w84L12Mitogen-activated protein kinase 14/0.469
2ydvNECAdenosine receptor A2a/0.469
3fklFKLMitogen-activated protein kinase 14/0.469
1w83L11Mitogen-activated protein kinase 14/0.468
1tl3H20Gag-Pol polyprotein2.7.7.490.467
2ewaSB2Mitogen-activated protein kinase 14/0.466
3flwFLWMitogen-activated protein kinase 14/0.466
4eh50OMMitogen-activated protein kinase 14/0.466
3fskRO6Mitogen-activated protein kinase 14/0.465
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.465
5iqaGNPBifunctional AAC/APH2.3.10.465
3pg3DG7Mitogen-activated protein kinase 14/0.464
1jlcFTCGag-Pol polyprotein2.7.7.490.463
3fgoCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.463
3fmjFMJMitogen-activated protein kinase 14/0.463
3qlhT27Gag-Pol polyprotein2.7.7.490.463
1yw2PGJMitogen-activated protein kinase 14/0.462
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.462
3lfcZ86Mitogen-activated protein kinase 14/0.462
3vtbTKAVitamin D3 receptor/0.462
5iqhGNPBifunctional AAC/APH2.3.10.462
1ppjANYCytochrome b/0.461
1kk4ACOStreptogramin A acetyltransferase2.3.10.460
3flzFLZMitogen-activated protein kinase 14/0.460
3gc7B45Mitogen-activated protein kinase 14/0.460
3hng8STVascular endothelial growth factor receptor 12.7.10.10.460
3l8xN4DMitogen-activated protein kinase 14/0.460
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.460
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
5k2bZMAAdenosine receptor A2a/0.459
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.458
3slkNDPPolyketide synthase extender module 2/0.458
3vt9YI4Vitamin D3 receptor/0.458
4ifvT27Gag-Pol polyprotein2.7.7.490.458
1ju6LYAThymidylate synthase2.1.1.450.457
4k9yK9YFocal adhesion kinase 12.7.10.20.457
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.456
3fmkFMKMitogen-activated protein kinase 14/0.456
4nks2M2Fibroblast growth factor receptor 1/0.456
1sj0E4DEstrogen receptor/0.455
2zd1T27Gag-Pol polyprotein2.7.7.490.455
3tm4SAMUncharacterized protein/0.455
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.455
4looSB4Mitogen-activated protein kinase 14/0.455
2yg4FADPutrescine oxidase/0.454
4id5T27Gag-Pol polyprotein2.7.7.490.454
4uhrNGIAdenosine receptor A2a/0.454
1kgjFL8Transthyretin/0.453
1kzjCB3Thymidylate synthase/0.453
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.453
2a4nCOAAac(6')-Ii protein/0.453
3uwlFOZThymidylate synthase/0.453
3vrwYS5Vitamin D3 receptor/0.453
4aacAAVMitogen-activated protein kinase 14/0.453
5uviZMAAdenosine receptor A2a/0.453
3rfmCFFAdenosine receptor A2a/0.453
1dgfNDPCatalase1.11.1.60.452
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3uq6ADNPutative adenosine kinase/0.452
4eh60ONMitogen-activated protein kinase 14/0.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
5dozNDPJamJ/0.452
5jy1NADPutative short-chain dehydrogenase/reductase/0.452
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.451
2c31ADPOxalyl-CoA decarboxylase4.1.1.80.451
2jfz003Glutamate racemase/0.451
2zbaZBATrichothecene 3-O-acetyltransferase/0.451
2ze2T27Gag-Pol polyprotein2.7.7.490.451
3uvp048Mitogen-activated protein kinase 14/0.451
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
4nk92K5Fibroblast growth factor receptor 1/0.451
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
1oc1ASVIsopenicillin N synthase1.21.3.10.450
2ji6ADPOxalyl-CoA decarboxylase4.1.1.80.450
2pulACPMethylthioribose kinase2.7.1.1000.450
3d0bSNXHeat shock protein HSP 90-alpha/0.450
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3p3zP3ZPutative cytochrome P450/0.450
3p6mDSOCamphor 5-monooxygenase1.14.15.10.450
3w5p4OAVitamin D3 receptor/0.450
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.450
4b8mVX6Aurora kinase B-A2.7.11.10.450
4eh70OOMitogen-activated protein kinase 14/0.450
4lb2DM5Serum albumin/0.450
4nka2K7Fibroblast growth factor receptor 1/0.450
4ruoBIVVitamin D3 receptor A/0.450
4z34ON7Lysophosphatidic acid receptor 1/0.450
3reyXACAdenosine receptor A2a/0.450
1ii6ADPKinesin-like protein KIF11/0.449
1lhvNOGSex hormone-binding globulin/0.449
1qknRALEstrogen receptor beta/0.449
2balPQAMitogen-activated protein kinase 14/0.449
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.449
3eptFDAPutative FAD-monooxygenase/0.449
3gcq1BUMitogen-activated protein kinase 14/0.449
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3s7a684Dihydrofolate reductase1.5.1.30.449
3up3XCAaceDAF-12/0.449
4iwc1GVEstrogen receptor/0.449
1n4hREANuclear receptor ROR-beta/0.448
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.448
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
2bakAQZMitogen-activated protein kinase 14/0.448
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
2qa2FADPolyketide oxygenase CabE/0.448
2qimZEAClass 10 plant pathogenesis-related protein/0.448
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3ukuC69Actin-related protein 3/0.448
4a9yAQZMitogen-activated protein kinase 14/0.448
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.448
4bb3KKAIsopenicillin N synthase1.21.3.10.448
4pmjNAPPutative oxidoreductase/0.448
4twpAXITyrosine-protein kinase ABL12.7.10.20.448
5kf1ACOPredicted acetyltransferase/0.448
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
1synF89Thymidylate synthase/0.447
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
2o7pNAPRiboflavin biosynthesis protein RibD/0.447
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.447
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.447
3vt7VDXVitamin D3 receptor/0.447
4eyjN61Mitogen-activated protein kinase 132.7.11.240.447
4jlj1NMDeoxycytidine kinase2.7.1.740.447
4mv1ADPBiotin carboxylase6.3.4.140.447
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.446
1ykdCMPAdenylate cyclase/0.446
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.446
2itzIREEpidermal growth factor receptor2.7.10.10.446
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.446
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3vtdTKDVitamin D3 receptor/0.446
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.446
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.446
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4h4o506Gag-Pol polyprotein2.7.7.490.446
4ib4ERM5-hydroxytryptamine receptor 2B/0.446
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.446
1g3lTRHGlucose-1-phosphate thymidylyltransferase/0.445
1rx5DDFDihydrofolate reductase1.5.1.30.445
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
2gqfFADUncharacterized protein HI_0933/0.445
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3dr1C5DVitamin D3 receptor A/0.445
3fmlFMLMitogen-activated protein kinase 14/0.445
3h1vTK1Glucokinase2.7.1.20.445
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3r9dX6BCyclin-dependent kinase 22.7.11.220.445
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4kip1R9Mitogen-activated protein kinase 14/0.445
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1mczRMNBenzoylformate decarboxylase4.1.1.70.444
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
2hcdBIVVitamin D3 receptor A/0.444
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.444
2vx07X7Ephrin type-B receptor 42.7.10.10.444
3cwkREACellular retinoic acid-binding protein 2/0.444
3fmh533Mitogen-activated protein kinase 14/0.444
3hp2P36Mitogen-activated protein kinase 14/0.444
3iw7IPKMitogen-activated protein kinase 14/0.444
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.444
3vrtYS2Vitamin D3 receptor/0.444
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.444
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4gk4L90Ephrin type-A receptor 32.7.10.10.444
4jlk1NODeoxycytidine kinase2.7.1.740.444
4ku5DCC3-oxoacyl-[ACP] synthase III/0.444
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.444
5iqdGNPBifunctional AAC/APH2.3.10.444
5k2aZMAAdenosine receptor A2a/0.444
1jutLYDThymidylate synthase/0.443
1p93DEXGlucocorticoid receptor/0.443
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.443
2w6oOA3Biotin carboxylase6.3.4.140.443
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.443
3zk5Z18Cytochrome P450 monooxygenase PikC/0.443
4f0fACPProbable serine/threonine-protein kinase roco42.7.11.10.443
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4g1y0VOVitamin D3 receptor A/0.443
4hni16WCasein kinase I isoform epsilon2.7.11.10.443
4i2pG73Gag-Pol polyprotein2.7.7.490.443
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.443
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.443
1bk0ACVIsopenicillin N synthase1.21.3.10.442
1dg5TOPDihydrofolate reductase1.5.1.30.442
1hk5T44Serum albumin/0.442
1jujLYAThymidylate synthase2.1.1.450.442
1tlcF89Thymidylate synthase/0.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
2vmyFFOSerine hydroxymethyltransferase/0.442
3mnrSD1Heat shock protein HSP 90-alpha/0.442
3qlxQLRUncharacterized protein/0.442
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4kaoKAOFocal adhesion kinase 12.7.10.20.442
4kfbT27Gag-Pol polyprotein2.7.7.490.442
4l9q9TPSerum albumin/0.442
4la0198Serum albumin/0.442
5iqbGNPBifunctional AAC/APH2.3.10.442
1bwlFMNNADPH dehydrogenase 11.6.99.10.441
1h36R88Squalene--hopene cyclase4.2.1.1290.441
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.441
2qk8MTXDihydrofolate reductase/0.441
2vkdUPGCytotoxin L/0.441
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.441
3mec65BGag-Pol polyprotein2.7.7.490.441
3meeT27Gag-Pol polyprotein2.7.7.490.441
3vtcTK3Vitamin D3 receptor/0.441
4fxfATPPyruvate kinase PKM2.7.1.400.441
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
2punACPMethylthioribose kinase2.7.1.1000.440
2rg6287Mitogen-activated protein kinase 14/0.440
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.440
2xir00JVascular endothelial growth factor receptor 22.7.10.10.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3iaeD7KBenzaldehyde lyase/0.440
3w33W19Epidermal growth factor receptor2.7.10.10.440
4g1qT27Gag-Pol polyprotein2.7.7.490.440
4g20484Vitamin D3 receptor A/0.440
4ia7BIVVitamin D3 receptor A/0.440
4ixgIXGDihydrofolate reductase1.5.1.30.440
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4jx1CAHCamphor 5-monooxygenase1.14.15.10.440
4ndnSAMS-adenosylmethionine synthase isoform type-22.5.1.60.440
4qi5FADCellobiose dehydrogenase/0.440
4yp7NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.440
5cccDDFDihydrofolate reductase1.5.1.30.440