sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 1.000 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.561 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.556 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.551 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.548 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.544 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.544 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.542 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.541 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.540 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.538 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.537 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.534 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.531 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.530 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.527 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.527 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.521 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.521 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.518 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.516 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.515 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.514 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.506 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.503 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.502 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.498 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.498 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.497 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.497 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.497 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.496 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.492 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.489 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.489 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.485 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.484 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.484 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.483 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.482 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.481 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.477 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.477 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.476 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.475 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.475 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.473 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.471 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.468 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.467 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.466 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.465 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.465 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.463 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.461 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.460 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.460 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.450 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.449 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.448 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.446 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.445 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.441 |