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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zuaTOLAldo-keto reductase family 1 member B101.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zuaTOLAldo-keto reductase family 1 member B101.1.11.000
4wevSUZAldo-keto reductase family 1 member B101.1.10.566
2fzdTOLAldose reductase1.1.1.210.563
2pdlTOLAldose reductase1.1.1.210.550
5liu388Aldo-keto reductase family 1 member B101.1.10.549
2pdh47DAldose reductase1.1.1.210.538
2pdfZSTAldose reductase1.1.1.210.531
2fzbTOLAldose reductase1.1.1.210.522
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.515
1ah3TOLAldose reductase1.1.1.210.513
2hvoZSTAldose reductase1.1.1.210.512
2pdmZSTAldose reductase1.1.1.210.491
2fz8ZSTAldose reductase1.1.1.210.485
2iki388Aldose reductase1.1.1.210.485
2pdj393Aldose reductase1.1.1.210.485
3ghtLDTAldose reductase1.1.1.210.482
2hvnZSTAldose reductase1.1.1.210.480
2pdiZSTAldose reductase1.1.1.210.480
3v35NTIAldose reductase1.1.1.210.480
2duxZSTAldose reductase1.1.1.210.477
3v94WYQPhosphodiesterase/0.476
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
3ghsLDTAldose reductase1.1.1.210.473
2dv0ZSTAldose reductase1.1.1.210.471
3ghrLDTAldose reductase1.1.1.210.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2pdxZSTAldose reductase1.1.1.210.469
3g5eQ74Aldose reductase1.1.1.210.469
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2pdg47DAldose reductase1.1.1.210.467
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.466
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1t40ID5Aldose reductase1.1.1.210.465
3zkuHCVIsopenicillin N synthase1.21.3.10.465
3lenZSTAldose reductase1.1.1.210.464
1ekoI84Aldose reductase1.1.1.210.462
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3m0iZSTAldose reductase1.1.1.210.462
1ieiZESAldose reductase1.1.1.210.461
2pdu393Aldose reductase1.1.1.210.460
3ghuLDTAldose reductase1.1.1.210.460
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.460
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.460
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2f3815MAldo-keto reductase family 1 member C3/0.458
2pdq47DAldose reductase1.1.1.210.458
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
3t423T4Aldose reductase1.1.1.210.458
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
2i17LDTAldose reductase1.1.1.210.457
2pdwFIDAldose reductase1.1.1.210.456
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
3k1wBFXRenin3.4.23.150.455
2hv5ZSTAldose reductase1.1.1.210.454
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
5fd8A5APutative carboxypeptidase yocD/0.453
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4gca2X9Aldose reductase1.1.1.210.452
2fz9ZSTAldose reductase1.1.1.210.451
2i16LDTAldose reductase1.1.1.210.451
3lboLDTAldose reductase1.1.1.210.451
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.451
1rxjBNIStreptavidin/0.450
1t41ID5Aldose reductase1.1.1.210.450
2pd9FIDAldose reductase1.1.1.210.450
3g70A5TRenin3.4.23.150.450
3mb9ZSTAldose reductase1.1.1.210.450
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1pqc444Oxysterols receptor LXR-beta/0.448
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4dbw511Aldo-keto reductase family 1 member C3/0.447
4fam0SZAldo-keto reductase family 1 member C3/0.447
1obnASVIsopenicillin N synthase1.21.3.10.445
1ry8RUTAldo-keto reductase family 1 member C3/0.445
1xf0ASDAldo-keto reductase family 1 member C3/0.445
3lqlLDTAldose reductase1.1.1.210.445
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.445
1pq944BOxysterols receptor LXR-beta/0.444
3ld5LDTAldose reductase1.1.1.210.444
2pdp393Aldose reductase1.1.1.210.443
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.443
3lz5LDTAldose reductase1.1.1.210.443
3m4h388Aldose reductase1.1.1.210.443
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.443
1ry0PG2Aldo-keto reductase family 1 member C3/0.442
1us0LDTAldose reductase1.1.1.210.442
1z8962PAldose reductase1.1.1.210.442
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
2pzn393Aldose reductase1.1.1.210.441
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3n0hTOPDihydrofolate reductase1.5.1.30.441
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4phlPILPhosphodiesterase/0.441
1thnADPAnti-sigma F factor/0.440
4yu153NAldose reductase1.1.1.210.440