sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1zhy | CLR | Oxysterol-binding protein homolog 4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1zhy | CLR | Oxysterol-binding protein homolog 4 | / | 1.000 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.631 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.496 | |
| 4iah | 1DX | Alr2278 protein | / | 0.496 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 4azw | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.488 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.485 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.481 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.480 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.478 | |
| 4n1g | CEI | Obelin | / | 0.478 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.477 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.476 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.475 | |
| 3i6r | J5Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.475 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.473 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.473 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.473 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.472 | |
| 2vqy | ACO | AAC(6')-Ib | / | 0.472 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.472 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.471 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.471 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.469 | |
| 3nks | ACJ | Protoporphyrinogen oxidase | 1.3.3.4 | 0.469 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.467 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.466 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.466 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.466 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.465 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.465 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.465 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3eks | CY9 | Actin-5C | / | 0.465 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.465 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.464 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.464 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.464 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.464 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.463 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.463 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.463 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.463 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.463 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.463 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.463 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.462 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.462 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.462 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.462 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.462 | |
| 4iae | 1DX | Alr2278 protein | / | 0.462 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.462 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.461 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.461 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.461 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.461 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.461 | |
| 3ojw | FAD | NADPH--cytochrome P450 reductase | / | 0.461 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.461 | |
| 4b1f | KRH | Glutamate racemase | / | 0.461 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.460 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.460 | |
| 1gaq | FAD | Ferredoxin | / | 0.460 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.460 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.460 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.460 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.459 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.459 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.459 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.459 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.459 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.459 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.459 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.459 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.458 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.458 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.458 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.458 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.458 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.458 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.458 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.458 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.457 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.457 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.457 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.457 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4boe | CLR | Japanin | / | 0.457 | |
| 4bqu | CLR | Japanin | / | 0.457 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.457 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.457 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.456 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.456 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.456 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.456 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.455 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.455 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.455 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.455 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.455 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.454 | |
| 1w29 | TS0 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.454 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.454 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.454 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.454 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.454 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.454 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.454 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.454 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.453 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.453 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3v2u | ATP | Protein GAL3 | / | 0.453 | |
| 4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.453 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.452 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.452 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.452 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.452 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.452 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.452 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 1eio | GCH | Gastrotropin | / | 0.451 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.451 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.451 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.451 | |
| 1wli | FMN | FMN-binding protein | / | 0.450 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.450 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.450 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.450 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.449 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.449 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.449 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.448 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.448 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.448 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.448 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.448 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.448 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.448 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.448 | |
| 4jey | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.448 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.448 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.448 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.447 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.447 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.447 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.447 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.447 | |
| 2h2j | SFG | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.447 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.447 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.447 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.447 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.447 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.447 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.447 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.446 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1ve7 | 4NP | Acylamino-acid-releasing enzyme | 3.4.19.1 | 0.446 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.446 | |
| 2tsr | D16 | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 2ya3 | J7V | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.446 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.446 | |
| 3gdu | TYR_ARG_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.446 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.446 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.446 | |
| 3i7v | B4P | AP4A hydrolase | / | 0.446 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.446 | |
| 5dp2 | NAP | CurF | / | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.445 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.445 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.445 | |
| 3c1o | NAP | Eugenol synthase | / | 0.445 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.445 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.444 | |
| 1sez | OMN | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.444 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.444 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.444 | |
| 2ohv | NHL | Glutamate racemase | / | 0.444 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 3arv | SAU | Chitinase A | / | 0.444 | |
| 3bnk | FMN | Flavoredoxin | / | 0.444 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.444 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.444 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.444 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.444 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.443 | |
| 1aqv | 0HG | Glutathione S-transferase P | 2.5.1.18 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.443 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.443 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.443 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.443 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.443 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.443 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 4ax8 | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.443 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.443 | |
| 4jxr | ACO | Acetyltransferase | / | 0.443 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.443 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.443 | |
| 1h72 | ANP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.442 | |
| 1own | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.442 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 3bj8 | COA | Diamine acetyltransferase 1 | / | 0.442 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.442 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.442 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.442 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.441 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.441 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.441 | |
| 2j6x | FMN | Lactate oxidase | / | 0.441 | |
| 2o12 | FMN | Chorismate synthase | / | 0.441 | |
| 2qiq | CYV | Replicase polyprotein 1ab | / | 0.441 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.441 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.441 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.441 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.441 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.441 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.441 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 1m4d | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.440 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.440 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.440 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.440 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.440 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2kce | D16 | Thymidylate synthase | / | 0.440 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.440 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.440 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.440 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.440 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.440 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.440 |