sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.754 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.743 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.721 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.705 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.703 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.693 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.690 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.684 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.672 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.669 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.666 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.665 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.664 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.663 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.662 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.661 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.658 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.656 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.653 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.649 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.644 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.641 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.638 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.634 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.633 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.631 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.630 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.630 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.616 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.616 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.615 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.615 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.611 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.608 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.599 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.596 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.593 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.587 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.586 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.583 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.578 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.564 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.551 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.547 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.536 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.530 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.530 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.515 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.508 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.496 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.475 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.475 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.470 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.469 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.466 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.462 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.462 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.460 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.457 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.456 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.452 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.452 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.452 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4kmz | FOL | Folate receptor beta | / | 0.450 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.449 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.449 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.449 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.448 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.447 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.446 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.445 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.444 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.444 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.442 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.442 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.441 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.441 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.441 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4nv7 | COA | Arylamine N-acetyltransferase | / | 0.440 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 |