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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1z3cSA8mRNA cap guanine-N7 methyltransferase2.1.1.56

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1z3cSA8mRNA cap guanine-N7 methyltransferase2.1.1.561.000
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.615
1ri3SAHmRNA cap guanine-N7 methyltransferase2.1.1.560.604
1ri4SAMmRNA cap guanine-N7 methyltransferase2.1.1.560.584
1ri2GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.483
3p62FMNPentaerythritol tetranitrate reductase/0.473
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.465
3toxNAPPutative oxidoreductase/0.460
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.460
2bu9HFVIsopenicillin N synthase1.21.3.10.457
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.456
4gl4NAIAlcohol dehydrogenase class-3/0.456
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.454
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.454
1ma0NADAlcohol dehydrogenase class-31.1.1.10.453
4qnwFMNChanoclavine-I aldehyde reductase easA/0.452
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.450
3w8fNAD3-hydroxybutyrate dehydrogenase/0.450
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.446
2iyfERYOleandomycin glycosyltransferase2.4.10.446
3d8vUD1Bifunctional protein GlmU/0.446
1g63FMNEpidermin decarboxylase4.1.10.445
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.445
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
2r8pT6FTransketolase 1/0.444
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
1culFOKAdenylate cyclase type 2/0.443
1culFOKAdenylate cyclase type 5/0.443
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.443
1ja0FMNNADPH--cytochrome P450 reductase/0.443
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4uthFMNXenobiotic reductase/0.443
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.442
2qs1UB1Glutamate receptor ionotropic, kainate 1/0.442
3muoZPRProlyl endopeptidase/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
4e2yJHZMethyltransferase/0.442
3f63GTXGlutathione transferase GST1-4/0.441
3ske054Genome polyprotein2.7.7.480.441
4xguADPPutative pachytene checkpoint protein 2/0.441
2bfoNDPPteridine reductase 11.5.1.330.440
2dv7SAHDiphthine synthase/0.440
2ylwNAPPhenylacetone monooxygenase1.14.13.920.440
3tr05GPGuanylate kinase/0.440
4bftZVTPantothenate kinase2.7.1.330.440
4briUNPEctonucleoside triphosphate diphosphohydrolase I/0.440
5cflC2EStimulator of interferon genes protein/0.440