sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1z1f | STL | Resveratrol synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1z1f | STL | Resveratrol synthase | / | 1.000 | |
| 1fml | RTL | Retinol dehydratase | / | 0.509 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.504 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.504 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.495 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.494 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.490 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.487 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.487 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.485 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.485 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.483 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.483 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.481 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.481 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.480 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.479 | |
| 4l06 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.479 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.477 | |
| 2owk | SAH | Diphthine synthase | / | 0.477 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.477 | |
| 1ppm | 0P1 | Penicillopepsin-1 | 3.4.23.20 | 0.476 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.476 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 2emu | SAH | Diphthine synthase | / | 0.475 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.474 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.474 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.473 | |
| 2dxv | SAH | Diphthine synthase | / | 0.473 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.473 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.473 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.473 | |
| 2e7r | SAH | Diphthine synthase | / | 0.472 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.472 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.472 | |
| 2p5f | SAH | Diphthine synthase | / | 0.470 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.470 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.470 | |
| 2owu | SAH | Diphthine synthase | / | 0.469 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.469 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.469 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.469 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.469 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.468 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.468 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.468 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.468 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.468 | |
| 3nxe | 2NC | Protease | / | 0.468 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.467 | |
| 2eni | SAH | Diphthine synthase | / | 0.467 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.466 | |
| 2huv | SAH | Diphthine synthase | / | 0.466 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.466 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.466 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.465 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.465 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.465 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.465 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.464 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 2ehl | SAH | Diphthine synthase | / | 0.464 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.464 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.464 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.464 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.464 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.464 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.464 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.463 | |
| 1vce | SAH | Diphthine synthase | / | 0.463 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.463 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.463 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.463 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.463 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1xef | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.462 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.462 | |
| 2ejz | SAH | Diphthine synthase | / | 0.462 | |
| 2hut | SAH | Diphthine synthase | / | 0.462 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.462 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.462 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.462 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4irn | FAD | AnaB | / | 0.462 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.462 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.462 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 2egs | SAH | Diphthine synthase | / | 0.461 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.461 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.460 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.460 | |
| 3ska | 053 | Genome polyprotein | 2.7.7.48 | 0.460 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.460 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.459 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.459 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.459 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.459 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.458 | |
| 1d7l | RFL | p-hydroxybenzoate hydroxylase | / | 0.458 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.458 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.458 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.458 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.458 | |
| 3lu8 | IQX | Serum albumin | / | 0.458 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.458 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.458 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.458 | |
| 4dpl | NAP | Malonyl-CoA reductase | 1.2.1.75 | 0.458 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4k9v | 6AW | Cytochrome P450 3A4 | / | 0.457 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.456 | |
| 2e8h | SAH | Diphthine synthase | / | 0.456 | |
| 2ejj | SAH | Diphthine synthase | / | 0.456 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.456 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.456 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.456 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.456 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.455 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.455 | |
| 1c6y | MK1 | Protease | / | 0.454 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 2dsg | SAH | Diphthine synthase | / | 0.454 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.454 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.454 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.454 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.454 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.454 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.454 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.453 | |
| 1yvf | PH7 | Polyprotein | / | 0.453 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 2huq | SAH | Diphthine synthase | / | 0.453 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.453 | |
| 2z6r | SAH | Diphthine synthase | / | 0.453 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.453 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.453 | |
| 3w5u | FAD | Ferredoxin | / | 0.453 | |
| 3zuy | TCH | Transporter | / | 0.453 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.453 | |
| 2eeq | SAH | Diphthine synthase | / | 0.452 | |
| 2egb | SAH | Diphthine synthase | / | 0.452 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 2jlb | UDM | Uncharacterized protein | / | 0.452 | |
| 2p5c | SAH | Diphthine synthase | / | 0.452 | |
| 2wq7 | FAD | RE11660p | / | 0.452 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.452 | |
| 3r95 | ACO | MccE protein | / | 0.452 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.452 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.452 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1z4u | PH9 | Polyprotein | / | 0.451 | |
| 2egl | SAH | Diphthine synthase | / | 0.451 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.451 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.451 | |
| 2pcg | SAH | Diphthine synthase | / | 0.451 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.451 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.451 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.451 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.451 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.451 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.450 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.450 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.450 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.450 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.450 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.450 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.450 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.450 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.450 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.450 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.450 | |
| 4y9u | FAD | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.449 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 2dxx | SAH | Diphthine synthase | / | 0.449 | |
| 2e08 | SAH | Diphthine synthase | / | 0.449 | |
| 2e16 | SAH | Diphthine synthase | / | 0.449 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 2q6s | PLB | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 3bnk | FMN | Flavoredoxin | / | 0.449 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.449 | |
| 3gob | HXX | DdmC | / | 0.449 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.449 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.448 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.448 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.448 | |
| 2e17 | SAH | Diphthine synthase | / | 0.448 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.448 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.448 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.448 | |
| 3u4o | 08E | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.447 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.447 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2p6i | SAH | Diphthine synthase | / | 0.447 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.447 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.447 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.447 | |
| 3mje | NDP | AmphB | / | 0.447 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.447 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.447 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.447 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.447 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.447 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.446 | |
| 1ryi | FAD | Glycine oxidase | 1.4.3.19 | 0.446 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.446 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.446 | |
| 2p6d | SAH | Diphthine synthase | / | 0.446 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.446 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.446 | |
| 3eek | 53S | Uncharacterized protein | / | 0.446 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.446 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.446 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.446 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.445 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.445 | |
| 2dxw | SAH | Diphthine synthase | / | 0.445 | |
| 2e07 | SAH | Diphthine synthase | / | 0.445 | |
| 2el0 | SAH | Diphthine synthase | / | 0.445 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.445 | |
| 2owv | SAH | Diphthine synthase | / | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.445 | |
| 3qly | 55V | Uncharacterized protein | / | 0.445 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3uph | 0C1 | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1gaq | FAD | Ferredoxin | / | 0.444 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 2dsh | SAH | Diphthine synthase | / | 0.444 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.444 | |
| 2el3 | SAH | Diphthine synthase | / | 0.444 | |
| 2gdo | 12C | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.444 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.444 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3dr8 | ACO | L-methionine sulfoximine/L-methionine sulfone acetyltransferase | / | 0.444 | |
| 3dtc | VIN | Mitogen-activated protein kinase kinase kinase 9 | 2.7.11.25 | 0.444 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.444 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.444 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.444 | |
| 3liv | E16 | Protease | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.444 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.444 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 5a3c | NAD | SIR2 family protein | / | 0.444 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1mrx | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1s7n | COA | Acetyl transferase | / | 0.443 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.443 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 2j4k | U5P | Uridylate kinase | 2.7.4.22 | 0.443 | |
| 2pck | SAH | Diphthine synthase | / | 0.443 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.443 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.443 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.443 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.442 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.442 | |
| 1knp | FAD | L-aspartate oxidase | 1.4.3.16 | 0.442 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.442 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.442 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.442 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.442 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.442 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3s43 | 478 | Protease | / | 0.442 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 4cgd | 8P3 | Integrase | / | 0.442 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.442 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.442 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.442 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 1d4h | BEH | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1gih | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.441 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.441 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.441 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.441 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.441 | |
| 2ejk | SAH | Diphthine synthase | / | 0.441 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.441 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.441 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.441 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 4a4q | UX9 | Pol protein | / | 0.441 | |
| 4b42 | 942 | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.441 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.441 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.441 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.441 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.440 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.440 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.440 | |
| 2oxt | SAM | Genome polyprotein | / | 0.440 | |
| 2pci | SAH | Diphthine synthase | / | 0.440 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 3bva | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3gpc | COA | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.440 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.440 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.440 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.440 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.440 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4y7c | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.440 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 |