Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 1.000 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.612 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.601 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.599 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.591 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.587 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.567 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.556 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.546 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.534 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.524 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.508 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.504 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.503 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.502 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.496 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.494 | |
| 1osv | CHC | Bile acid receptor | / | 0.493 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.493 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.492 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.491 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.490 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.490 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.487 | |
| 1ppj | ANY | Cytochrome b | / | 0.486 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.486 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.486 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.485 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.485 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.484 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.482 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.481 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.480 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.479 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.479 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.478 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.477 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.477 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 1ez0 | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.476 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.476 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.474 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.472 | |
| 5epo | TUD | 7-alpha-hydroxysteroid deydrogenase | / | 0.472 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 1qsn | COA | HAT A1 | / | 0.471 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 2xvv | 9DN | Serum albumin | / | 0.470 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.470 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.470 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.469 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.468 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.468 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.468 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.467 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.467 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.467 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.466 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.466 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.466 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.466 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.466 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 3eks | CY9 | Actin-5C | / | 0.465 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.465 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.465 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.464 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.464 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1zdw | FLV | Prenyltransferase | / | 0.463 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.462 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.462 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.462 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.462 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.462 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.462 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.462 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.462 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.462 | |
| 4zth | GG5 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.462 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.461 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.461 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.461 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.460 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.460 | |
| 2pda | TPP | Pyruvate synthase | / | 0.460 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.460 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.460 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.460 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.460 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.460 | |
| 1pu9 | COA | HAT A1 | / | 0.459 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.459 | |
| 3rix | 923 | Luciferin 4-monooxygenase | 1.13.12.7 | 0.459 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.459 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.459 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.459 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.459 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.458 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.458 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.458 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.458 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2xvw | 9NR | Serum albumin | / | 0.458 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.458 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.458 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.458 | |
| 1q3h | ANP | Cystic fibrosis transmembrane conductance regulator | / | 0.457 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.457 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.457 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.457 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.457 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4aox | FAD | Steroid monooxygenase | / | 0.457 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.457 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.457 | |
| 4n6b | COA | Uncharacterized protein | / | 0.457 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1qy5 | NEC | Endoplasmin | / | 0.456 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.456 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.456 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.456 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.456 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 3up0 | D7S | aceDAF-12 | / | 0.456 | |
| 4bj8 | BTN | Avidin | / | 0.456 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.456 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.456 | |
| 2e17 | SAH | Diphthine synthase | / | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.455 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3rq8 | AP5 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.455 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4hxy | NDP | Plm1 | / | 0.455 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.455 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.455 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.454 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.454 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.454 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.454 | |
| 4irn | FAD | AnaB | / | 0.454 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4tm0 | FAD | KtzI | / | 0.454 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.454 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.453 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.453 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.453 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.453 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.453 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.453 | |
| 4c2j | COA | 3-ketoacyl-CoA thiolase, mitochondrial | 2.3.1.16 | 0.453 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.452 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2b1z | 17M | Estrogen receptor | / | 0.452 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.452 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.452 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.452 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2e08 | SAH | Diphthine synthase | / | 0.451 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.451 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.451 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.451 | |
| 4b0c | C9H | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.451 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.451 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.451 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1ofg | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.450 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.450 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.450 | |
| 2plm | SIB | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | 3.5.4.28 | 0.450 | |
| 3arv | SAU | Chitinase A | / | 0.450 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.450 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.450 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.450 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.450 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.449 | |
| 2bun | FAD | AppA protein | / | 0.449 | |
| 2fiw | ACO | GCN5-related N-acetyltransferase:Aminotransferase, class-II | / | 0.449 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.449 | |
| 2o12 | FMN | Chorismate synthase | / | 0.449 | |
| 3bwj | ARX | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.449 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4kwh | NAP | Reductase homolog | / | 0.449 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.448 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.448 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 1uh5 | TCL | Enoyl-ACP reductase | / | 0.448 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.448 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.448 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.448 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 2vcw | ZZA | Hematopoietic prostaglandin D synthase | / | 0.448 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.448 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.448 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.448 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.448 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.448 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.448 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.448 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2e15 | SAH | Diphthine synthase | / | 0.447 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.447 | |
| 3b9l | AZZ | Serum albumin | / | 0.447 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.447 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.447 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.447 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 2dsi | SAH | Diphthine synthase | / | 0.446 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.446 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2y3s | TIR | TamL | / | 0.446 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.446 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.446 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.446 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.445 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1sre | HAB | Streptavidin | / | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.445 | |
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.445 | |
| 3csj | CBL | Glutathione S-transferase P | 2.5.1.18 | 0.445 | |
| 3fnf | JPM | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3gki | CLR | Niemann-Pick C1 protein | / | 0.445 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.445 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.445 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.445 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.445 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1axw | MTX | Thymidylate synthase | / | 0.444 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.444 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.444 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.444 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.444 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.444 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 3il5 | B82 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.444 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.444 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.444 | |
| 4exs | X8Z | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.443 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.443 | |
| 1g8o | U5P | N-acetyllactosaminide alpha-1,3-galactosyltransferase | / | 0.443 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.443 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.443 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 2hg1 | N5O | Endoplasmin | / | 0.443 | |
| 2jib | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.443 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.443 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.443 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.443 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.443 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.443 | |
| 4isz | GAV | tRNA-splicing ligase RtcB | 6.5.1 | 0.443 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.443 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.443 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.442 | |
| 1dqa | COA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.442 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.442 | |
| 1srf | MTB | Streptavidin | / | 0.442 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.442 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2fr3 | REA | Cellular retinoic acid-binding protein 2 | / | 0.442 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2h2a | DND | Probable nicotinate-nucleotide adenylyltransferase | / | 0.442 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.442 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.442 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3rdq | DTB | Streptavidin | / | 0.442 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.442 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.442 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.442 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.442 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.441 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.441 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.441 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.441 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.441 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.441 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.441 | |
| 2c3p | 1TP | Pyruvate synthase | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2p5c | SAH | Diphthine synthase | / | 0.441 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.441 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2xs4 | ALA_PHE_THR | Karilysin | 3.4.24 | 0.441 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3bnk | FMN | Flavoredoxin | / | 0.441 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3hl7 | I46 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.441 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.441 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.441 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4iae | 1DX | Alr2278 protein | / | 0.441 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4pzt | SOP | Histone acetyltransferase p300 | / | 0.441 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.441 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5h86 | BCO | Histone acetyltransferase KAT2A | 2.3.1.48 | 0.441 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.441 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.440 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.440 | |
| 1e7a | PFL | Serum albumin | / | 0.440 | |
| 1fml | RTL | Retinol dehydratase | / | 0.440 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.440 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.440 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.440 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.440 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.440 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.440 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.440 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.440 | |
| 2e83 | FMN | FMN-binding protein | / | 0.440 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.440 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.440 | |
| 4b1f | KRH | Glutamate racemase | / | 0.440 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.440 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.440 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.440 | |
| 4z28 | BTN | Hoefavidin | / | 0.440 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 |