sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.708 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.693 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.692 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.685 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.669 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.628 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.532 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.519 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.519 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.513 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.503 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.485 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.481 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.480 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.480 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.478 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.473 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.471 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.467 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.467 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.467 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.465 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.463 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.461 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.460 | |
| 2y3s | TIR | TamL | / | 0.459 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.452 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.452 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.450 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.448 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.446 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 5a3c | NAD | SIR2 family protein | / | 0.444 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.443 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.442 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 |