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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.11.000
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.675
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.670
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.661
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.646
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.637
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.623
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.621
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.612
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.610
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.608
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.605
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.604
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.602
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.594
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.593
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.593
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.591
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.589
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.587
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.584
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.584
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.580
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.572
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.572
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.570
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.567
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.566
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.566
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.565
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.563
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.561
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.559
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.556
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.553
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.553
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.552
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.552
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.546
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.539
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.537
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.537
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.535
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.535
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.534
4i22IREEpidermal growth factor receptor2.7.10.10.531
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.522
4othDRNSerine/threonine-protein kinase N1/0.522
4bgg844Activin receptor type-12.7.11.300.518
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.517
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.513
1xjdSTUProtein kinase C theta type2.7.11.130.512
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.507
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.505
4jq8KJ8Epidermal growth factor receptor2.7.10.10.505
2jedLG8Protein kinase C theta type2.7.11.130.504
4fnyI3KALK tyrosine kinase receptor2.7.10.10.503
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.502
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.501
3umw596Serine/threonine-protein kinase pim-12.7.11.10.500
3iw4LW4Protein kinase C alpha type2.7.11.130.499
4dymIYZActivin receptor type-12.7.11.300.499
4wboANWRhodopsin kinase/0.497
3gubGUBDeath-associated protein kinase 12.7.11.10.496
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.495
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
3a4pDFQHepatocyte growth factor receptor2.7.10.10.494
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.494
3uyt0CKCasein kinase I isoform delta2.7.11.10.494
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.494
1pkdUCNCyclin-dependent kinase 22.7.11.220.493
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.493
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.493
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.493
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.492
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.492
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.492
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.491
3oom507Activin receptor type-12.7.11.300.490
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.490
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.490
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.490
2j0m4STFocal adhesion kinase 12.7.10.20.489
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.489
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.489
1aq1STUCyclin-dependent kinase 22.7.11.220.488
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.488
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.487
2wihP48Cyclin-dependent kinase 22.7.11.220.487
3u4uLNHCasein kinase II subunit alpha2.7.11.10.487
1h1s4SPCyclin-dependent kinase 22.7.11.220.486
2pvnP63Casein kinase II subunit alpha2.7.11.10.486
2ckeIQUDeath-associated protein kinase 2/0.485
4bchT7ZCyclin-dependent kinase 92.7.11.220.485
5cvhADPCasein kinase II subunit alpha2.7.11.10.484
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.483
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.483
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.483
1yvj4STTyrosine-protein kinase JAK32.7.10.20.482
2iw84SPCyclin-dependent kinase 22.7.11.220.482
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.482
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.481
4dgnLU2Casein kinase II subunit alpha2.7.11.10.481
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.479
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.478
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.478
4gmy0X5Tyrosine-protein kinase JAK2/0.478
4yuqKS1Calmodulin-like domain protein kinase/0.478
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.477
1bygSTUTyrosine-protein kinase CSK/0.476
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.476
1wvxBD4Death-associated protein kinase 12.7.11.10.476
2pvlP55Casein kinase II subunit alpha2.7.11.10.476
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.476
4grb0XGCasein kinase II subunit alpha2.7.11.10.476
4riyADPEpidermal growth factor receptor2.7.10.10.476
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3at4CCKCasein kinase II subunit alpha2.7.11.10.475
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.475
4gg70J8Hepatocyte growth factor receptor2.7.10.10.475
1oi9N20Cyclin-dependent kinase 22.7.11.220.474
2j0j4STFocal adhesion kinase 12.7.10.20.474
3q9xEMOCasein kinase II subunit alpha2.7.11.10.474
4fob0USALK tyrosine kinase receptor2.7.10.10.474
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.474
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.473
2etm7PYFocal adhesion kinase 12.7.10.20.473
2om9AJAPeroxisome proliferator-activated receptor gamma/0.473
3bu5ATPInsulin receptor2.7.10.10.472
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.471
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.471
3mtfA3FActivin receptor type-12.7.11.300.470
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.470
4jia1K3Tyrosine-protein kinase JAK2/0.470
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.469
3zxtACPDeath-associated protein kinase 12.7.11.10.469
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.469
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.469
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.469
4nb6444Nuclear receptor ROR-gamma/0.469
4nc3ERM5-hydroxytryptamine receptor 2B/0.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
1oiuN76Cyclin-dependent kinase 22.7.11.220.468
1q4u4CA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.468
3hllI45Mitogen-activated protein kinase 14/0.468
3r9dX6BCyclin-dependent kinase 22.7.11.220.468
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.468
4erwSTUCyclin-dependent kinase 22.7.11.220.468
4hvi19STyrosine-protein kinase JAK32.7.10.20.468
5auwQUEDeath-associated protein kinase 12.7.11.10.468
2iw94SPCyclin-dependent kinase 22.7.11.220.467
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.467
4fod0UVALK tyrosine kinase receptor2.7.10.10.467
4kba1QMCasein kinase I isoform delta2.7.11.10.467
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.466
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.466
4otiMI1Serine/threonine-protein kinase N1/0.466
1oiyN41Cyclin-dependent kinase 22.7.11.220.465
1zys199Serine/threonine-protein kinase Chk12.7.11.10.465
2i40BLZCyclin-dependent kinase 22.7.11.220.465
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.465
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.465
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.465
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.464
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.464
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.464
1e9hINRCyclin-dependent kinase 22.7.11.220.463
1eh4IC1Casein kinase I homolog 12.7.11.10.463
2ittAEEEpidermal growth factor receptor2.7.10.10.463
4qmzB49Serine/threonine-protein kinase 242.7.11.10.463
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.462
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.462
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.462
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.462
3bqr4RBDeath-associated protein kinase 3/0.462
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.462
2cchATPCyclin-dependent kinase 22.7.11.220.461
2chlDKICasein kinase I isoform gamma-32.7.11.10.461
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.461
4b99R4LMitogen-activated protein kinase 72.7.11.240.461
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.461
1kkq471Peroxisome proliferator-activated receptor alpha/0.460
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.460
2eufLQQCyclin-dependent kinase 62.7.11.220.460
5e8wSTUTGF-beta receptor type-12.7.11.300.460
1oguST8Cyclin-dependent kinase 22.7.11.220.459
2h96893Mitogen-activated protein kinase 82.7.11.240.459
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
2uxpCLMHTH-type transcriptional regulator TtgR/0.459
3gu6ADPDeath-associated protein kinase 12.7.11.10.459
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.459
4eok4SPCyclin-dependent kinase 22.7.11.220.459
4fx360KCyclin-dependent kinase 22.7.11.220.459
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.459
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1qxlFR8Adenosine deaminase3.5.4.40.458
1u4dDBQActivated CDC42 kinase 1/0.458
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.458
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.458
4b7dQLECytochrome P450 monooxygenase PikC/0.458
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.458
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2b52D42Cyclin-dependent kinase 22.7.11.220.457
2fxdDR7Pol polyprotein/0.457
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.457
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.457
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.457
2zjwREFCasein kinase II subunit alpha2.7.11.10.457
3gc9B45Mitogen-activated protein kinase 112.7.11.240.457
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3uli1N3Cyclin-dependent kinase 22.7.11.220.457
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.457
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.456
2uzlC94Cyclin-dependent kinase 22.7.11.220.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.456
3livE16Protease/0.456
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.456
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.456
4ib4ERM5-hydroxytryptamine receptor 2B/0.456
5cu6ATPCasein kinase II subunit alpha2.7.11.10.456
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.455
2x1nX1NCyclin-dependent kinase 22.7.11.220.455
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.455
3a60STURibosomal protein S6 kinase beta-12.7.11.10.455
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.455
3mqe416Prostaglandin G/H synthase 21.14.99.10.455
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.455
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4hvh19RTyrosine-protein kinase JAK32.7.10.20.455
4iarERM5-hydroxytryptamine receptor 1B/0.455
4lopSB4Mitogen-activated protein kinase 14/0.455
1gih1PUCyclin-dependent kinase 22.7.11.220.454
1pmn984Mitogen-activated protein kinase 102.7.11.240.454
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.454
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.454
3oroAGSSerine/threonine protein kinase/0.454
3qaiXNNKetohexokinase/0.454
4hvg19QTyrosine-protein kinase JAK32.7.10.20.454
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.454
4nk92K5Fibroblast growth factor receptor 1/0.454
4wsqKSAAP2-associated protein kinase 12.7.11.10.454
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1lp4ANPCasein kinase II subunit alpha2.7.11.10.453
1rfvADPPyridoxal kinase2.7.1.350.453
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.453
2hog710Serine/threonine-protein kinase Chk12.7.11.10.453
2uxuNARHTH-type transcriptional regulator TtgR/0.453
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.453
2xikJ60Serine/threonine-protein kinase 252.7.11.10.453
3blrCPBCyclin-dependent kinase 92.7.11.220.453
3oqkS52Renin3.4.23.150.453
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bbe3O4Tyrosine-protein kinase JAK2/0.453
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.453
5f0a1FBcGMP-dependent protein kinase, putative/0.453
1h1r6CPCyclin-dependent kinase 22.7.11.220.452
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.452
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.452
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.452
3be9P04Casein kinase II subunit alpha2.7.11.10.452
3oafOAGDihydrofolate reductase1.5.1.30.452
3r3b4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
3vt8YI3Vitamin D3 receptor/0.452
3vt9YI4Vitamin D3 receptor/0.452
3zh8C58Protein kinase C iota type2.7.11.130.452
4b7sQLECytochrome P450 monooxygenase PikC/0.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
4kbk1QGCasein kinase I isoform delta2.7.11.10.452
2uzbC75Cyclin-dependent kinase 22.7.11.220.451
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.451
3ormAGSSerine/threonine protein kinase/0.451
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.451
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.451
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.451
2c6hPXICytochrome P450 monooxygenase PikC/0.450
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.450
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.450
3mpaSB2Mitogen-activated protein kinase 14/0.450
3r7kFDAProbable acyl CoA dehydrogenase/0.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4g160VMCasein kinase I isoform gamma-32.7.11.10.450
4gu94GUFocal adhesion kinase 12.7.10.20.450
4hni16WCasein kinase I isoform epsilon2.7.11.10.450
4uymVOR14-alpha sterol demethylase Cyp51B/0.450
1g5sI17Cyclin-dependent kinase 22.7.11.220.449
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2p33J07Mitogen-activated protein kinase 102.7.11.240.449
3a62STURibosomal protein S6 kinase beta-12.7.11.10.449
3at3ATKCasein kinase II subunit alpha2.7.11.10.449
3litE15Protease/0.449
3so9017Pol protein/0.449
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.449
3zze6XPHepatocyte growth factor receptor2.7.10.10.449
5auvAGIDeath-associated protein kinase 12.7.11.10.449
5e8ySTUTGF-beta receptor type-22.7.11.300.449
1u54ACPActivated CDC42 kinase 1/0.448
2c7xNRBCytochrome P450 monooxygenase PikC/0.448
2izrBRKCasein kinase I isoform gamma-32.7.11.10.448
2w1fL0FAurora kinase A2.7.11.10.448
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.448
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.448
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.448
3w33W19Epidermal growth factor receptor2.7.10.10.448
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.448
4g1wG1WMitogen-activated protein kinase 82.7.11.240.448
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.448
1m2pHNACasein kinase II subunit alpha2.7.11.10.447
2xnbY8LCyclin-dependent kinase 22.7.11.220.447
3lixE17Protease/0.447
3mtlFEFCyclin-dependent kinase 162.7.11.220.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.447
4c4f7CEDual specificity protein kinase TTK2.7.12.10.447
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
5cshATPCasein kinase II subunit alpha2.7.11.10.447
1bai0Q4Gag-Pro polyprotein/0.446
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3c4zADPRhodopsin kinase/0.446
3kf7L9GMitogen-activated protein kinase 14/0.446
3p4tFAOPutative acyl-CoA dehydrogenase/0.446
4c4jX21Dual specificity protein kinase TTK2.7.12.10.446
4jqeANPCasein kinase II subunit alpha2.7.11.10.446
4qmpDKISerine/threonine-protein kinase 242.7.11.10.446
5av2KMPDeath-associated protein kinase 12.7.11.10.446
1umlFR4Adenosine deaminase3.5.4.40.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
2w05FRTCyclin-dependent kinase 22.7.11.220.445
2wpa889Cyclin-dependent kinase 22.7.11.220.445
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.445
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.445
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.445
3mdvCL6Cholesterol 24-hydroxylase/0.445
3nynSGVG protein-coupled receptor kinase 62.7.11.160.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3rpv26ZCyclin-dependent kinase 22.7.11.220.445
3sw719KCyclin-dependent kinase 22.7.11.220.445
3w18N13Aurora kinase A2.7.11.10.445
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.445
4eoi1ROCyclin-dependent kinase 22.7.11.220.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4fyn0VETyrosine-protein kinase SYK2.7.10.20.445
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
1fmjRTLRetinol dehydratase/0.444
1ie4T44Transthyretin/0.444
1ppm0P1Penicillopepsin-13.4.23.200.444
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.444
1y0s331Peroxisome proliferator-activated receptor delta/0.444
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.444
2hw2RFPRifampin ADP-ribosyl transferase/0.444
2uzeC95Cyclin-dependent kinase 22.7.11.220.444
2wedPP6Penicillopepsin-13.4.23.200.444
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3nga3NGCasein kinase II subunit alpha2.7.11.10.444
3opdHIEHeat shock protein 83/0.444
3s1h56ZCyclin-dependent kinase 22.7.11.220.444
3uzp0CKCasein kinase I isoform delta2.7.11.10.444
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.444
3zewSTUEphrin type-B receptor 42.7.10.10.444
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.444
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4gu610NFocal adhesion kinase 12.7.10.20.444
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.444
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.444
4kb81QNCasein kinase I isoform delta2.7.11.10.444
4wkqIREEpidermal growth factor receptor2.7.10.10.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1jioDEB6-deoxyerythronolide B hydroxylase/0.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
2izsBRQCasein kinase I isoform gamma-32.7.11.10.443
2j0k4STFocal adhesion kinase 12.7.10.20.443
2jkoBIJFocal adhesion kinase 12.7.10.20.443
2uxoTACHTH-type transcriptional regulator TtgR/0.443
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.443
3eljGS7Mitogen-activated protein kinase 82.7.11.240.443
3gbuATPUncharacterized sugar kinase PH14592.7.10.443
3rni21ZCyclin-dependent kinase 22.7.11.220.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.443
4gub0Y4Casein kinase II subunit alpha2.7.11.10.443
4hnf16WCasein kinase I isoform delta2.7.11.10.443
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.442
2c3qGTXGlutathione S-transferase theta-12.5.1.180.442
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.442
2itpAEEEpidermal growth factor receptor2.7.10.10.442
2pvhP19Casein kinase II subunit alpha2.7.11.10.442
2vagV25Dual specificity protein kinase CLK12.7.12.10.442
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.442
3fl8RARDihydrofolate reductase/0.442
3ortAGSSerine/threonine protein kinase/0.442
3qa2XNAKetohexokinase/0.442
3r9hZ67Cyclin-dependent kinase 22.7.11.220.442
3rk909ZCyclin-dependent kinase 22.7.11.220.442
3t113T1Gag-Pol polyprotein3.4.23.160.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
4eon1ROCyclin-dependent kinase 22.7.11.220.442
4g170VNCasein kinase I isoform gamma-32.7.11.10.442
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.442
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
5dt4ATPAurora kinase A2.7.11.10.442
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.441
2ijmADPFocal adhesion kinase 12.7.10.20.441
2q59240Peroxisome proliferator-activated receptor gamma/0.441
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.441
2znnS44Peroxisome proliferator-activated receptor alpha/0.441
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.441
3l8p0CEAngiopoietin-1 receptor2.7.10.10.441
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3q9zTXQCasein kinase II subunit alpha2.7.11.10.441
3s1cZIRCytokinin dehydrogenase 11.5.99.120.441
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4hgs15GCasein kinase I isoform gamma-32.7.11.10.441
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.441
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1ke6LS2Cyclin-dependent kinase 22.7.11.220.440
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.440
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.440
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.440
2j4z626Aurora kinase A2.7.11.10.440
2jkqVG8Focal adhesion kinase 12.7.10.20.440
2q9fC3SCholesterol 24-hydroxylase/0.440
2y3rTRKTamL/0.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.440
3nszANPCasein kinase II subunit alpha2.7.11.10.440
3q92XNBKetohexokinase/0.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3t2zFADSulfide-quinone reductase/0.440
3t8oATPRhodopsin kinase/0.440
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.440
4foc0UUALK tyrosine kinase receptor2.7.10.10.440
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4iwv1J9Glucokinase2.7.1.20.440
4jboWPHAurora kinase A2.7.11.10.440
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.440
4l9i8PRRhodopsin kinase/0.440
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.440