sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.493 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3p9t | TCL | Repressor | / | 0.481 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.479 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.461 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.456 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.455 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.453 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.450 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.449 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.448 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.448 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.447 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.445 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.441 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.441 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.440 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.440 |