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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1y8yCT7Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1y8yCT7Cyclin-dependent kinase 22.7.11.221.000
2c6iDT1Cyclin-dependent kinase 22.7.11.220.638
3qtxX43Cyclin-dependent kinase 22.7.11.220.633
3rm719ZCyclin-dependent kinase 22.7.11.220.629
2c6kDT2Cyclin-dependent kinase 22.7.11.220.624
2c6mDT5Cyclin-dependent kinase 22.7.11.220.615
2r3iSCFCyclin-dependent kinase 22.7.11.220.615
4fko20KCyclin-dependent kinase 22.7.11.220.615
2xmyCDKCyclin-dependent kinase 22.7.11.220.614
3r8uZ31Cyclin-dependent kinase 22.7.11.220.607
4fks46KCyclin-dependent kinase 22.7.11.220.594
3qtqX35Cyclin-dependent kinase 22.7.11.220.586
1h0w207Cyclin-dependent kinase 22.7.11.220.585
2c6lDT4Cyclin-dependent kinase 22.7.11.220.582
2r3o2SCCyclin-dependent kinase 22.7.11.220.577
3r8vZ62Cyclin-dependent kinase 22.7.11.220.576
4fkq42KCyclin-dependent kinase 22.7.11.220.575
4ek816KCyclin-dependent kinase 22.7.11.220.568
2vv9IM9Cyclin-dependent kinase 22.7.11.220.561
2r3r6SCCyclin-dependent kinase 22.7.11.220.560
3r71X86Cyclin-dependent kinase 22.7.11.220.560
3r7vZ02Cyclin-dependent kinase 22.7.11.220.558
3qx2X63Cyclin-dependent kinase 22.7.11.220.555
3rni21ZCyclin-dependent kinase 22.7.11.220.553
1gih1PUCyclin-dependent kinase 22.7.11.220.552
4fkv61KCyclin-dependent kinase 22.7.11.220.552
3r9nZ68Cyclin-dependent kinase 22.7.11.220.551
3r9hZ67Cyclin-dependent kinase 22.7.11.220.550
2r3lSCWCyclin-dependent kinase 22.7.11.220.548
3rak03ZCyclin-dependent kinase 22.7.11.220.548
2r3q5SCCyclin-dependent kinase 22.7.11.220.547
3rpv26ZCyclin-dependent kinase 22.7.11.220.547
2c6o4SPCyclin-dependent kinase 22.7.11.220.546
2w17I19Cyclin-dependent kinase 22.7.11.220.544
3sw719KCyclin-dependent kinase 22.7.11.220.544
3rahO1ZCyclin-dependent kinase 22.7.11.220.542
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.541
3r73X87Cyclin-dependent kinase 22.7.11.220.540
3qxoX65Cyclin-dependent kinase 22.7.11.220.539
3rk708ZCyclin-dependent kinase 22.7.11.220.539
3s1h56ZCyclin-dependent kinase 22.7.11.220.539
3rk507ZCyclin-dependent kinase 22.7.11.220.538
1oitHDTCyclin-dependent kinase 22.7.11.220.537
2c6tDT5Cyclin-dependent kinase 22.7.11.220.537
3qzhX69Cyclin-dependent kinase 22.7.11.220.537
1fvv107Cyclin-dependent kinase 22.7.11.220.536
3r8lZ30Cyclin-dependent kinase 22.7.11.220.536
3ezvEZVCyclin-dependent kinase 22.7.11.220.534
3rk909ZCyclin-dependent kinase 22.7.11.220.534
2r3fSC8Cyclin-dependent kinase 22.7.11.220.533
3rmf20ZCyclin-dependent kinase 22.7.11.220.533
1p2a5BNCyclin-dependent kinase 22.7.11.220.531
3ral04ZCyclin-dependent kinase 22.7.11.220.530
4fkt48KCyclin-dependent kinase 22.7.11.220.530
4fklCK2Cyclin-dependent kinase 22.7.11.220.529
1dm2HMDCyclin-dependent kinase 22.7.11.220.528
1v0pPVBCell division control protein 2 homolog2.7.11.220.527
2w06FRVCyclin-dependent kinase 22.7.11.220.526
4bgh3I6Cyclin-dependent kinase 22.7.11.220.526
3sw418KCyclin-dependent kinase 22.7.11.220.525
2r3jSCJCyclin-dependent kinase 22.7.11.220.524
2uznC96Cyclin-dependent kinase 22.7.11.220.524
3qwjX6ACyclin-dependent kinase 22.7.11.220.524
2r64740Cyclin-dependent kinase 22.7.11.220.522
2vtsLZCCyclin-dependent kinase 22.7.11.220.522
3raiX85Cyclin-dependent kinase 22.7.11.220.522
3sqq99ZCyclin-dependent kinase 22.7.11.220.522
1ke6LS2Cyclin-dependent kinase 22.7.11.220.521
1ykr628Cyclin-dependent kinase 22.7.11.220.521
1w8cN69Cyclin-dependent kinase 22.7.11.220.520
1ke7LS3Cyclin-dependent kinase 22.7.11.220.519
1y91CT9Cyclin-dependent kinase 22.7.11.220.519
3rjc06ZCyclin-dependent kinase 22.7.11.220.519
1pxmCK5Cyclin-dependent kinase 22.7.11.220.518
2vthLZ2Cyclin-dependent kinase 22.7.11.220.518
3qtzX42Cyclin-dependent kinase 22.7.11.220.518
4kd11QKCyclin-dependent kinase 22.7.11.220.518
2r3p3SCCyclin-dependent kinase 22.7.11.220.517
2w05FRTCyclin-dependent kinase 22.7.11.220.517
2b53D23Cyclin-dependent kinase 22.7.11.220.516
3r8zZ63Cyclin-dependent kinase 22.7.11.220.516
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.515
3iggEFQCyclin-dependent kinase 22.7.11.220.515
1ke9LS5Cyclin-dependent kinase 22.7.11.220.514
2uzlC94Cyclin-dependent kinase 22.7.11.220.514
2uzoC62Cyclin-dependent kinase 22.7.11.220.514
3s00Z60Cyclin-dependent kinase 22.7.11.220.514
1pxjCK2Cyclin-dependent kinase 22.7.11.220.513
3qxpX64Cyclin-dependent kinase 22.7.11.220.513
3qqkX02Cyclin-dependent kinase 22.7.11.220.512
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.511
3qtuX44Cyclin-dependent kinase 22.7.11.220.509
4fkr45KCyclin-dependent kinase 22.7.11.220.509
3r7uX96Cyclin-dependent kinase 22.7.11.220.508
2duv371Cyclin-dependent kinase 22.7.11.220.507
3lfqA28Cyclin-dependent kinase 22.7.11.220.507
4fkw62KCyclin-dependent kinase 22.7.11.220.507
1e1xNW1Cyclin-dependent kinase 22.7.11.220.506
4ek610KCyclin-dependent kinase 22.7.11.220.506
2c69CT8Cyclin-dependent kinase 22.7.11.220.504
3ezrEZRCyclin-dependent kinase 22.7.11.220.504
3le62BZCyclin-dependent kinase 22.7.11.220.504
1oguST8Cyclin-dependent kinase 22.7.11.220.503
1pxpCK8Cyclin-dependent kinase 22.7.11.220.503
1oirHDYCyclin-dependent kinase 22.7.11.220.502
2bheBRYCyclin-dependent kinase 22.7.11.220.502
2r3gSC9Cyclin-dependent kinase 22.7.11.220.502
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.502
3ddpRC8Cyclin-dependent kinase 22.7.11.220.502
4fkpLS5Cyclin-dependent kinase 22.7.11.220.502
1ke5LS1Cyclin-dependent kinase 22.7.11.220.501
1v1k3FPCyclin-dependent kinase 22.7.11.220.501
2r3kSCQCyclin-dependent kinase 22.7.11.220.501
3qu0X40Cyclin-dependent kinase 22.7.11.220.501
2wihP48Cyclin-dependent kinase 22.7.11.220.500
3qtsX46Cyclin-dependent kinase 22.7.11.220.500
3s0o50ZCyclin-dependent kinase 22.7.11.220.500
4acm7YGCyclin-dependent kinase 22.7.11.220.500
4eomATPCyclin-dependent kinase 22.7.11.220.500
1pyePM1Cyclin-dependent kinase 22.7.11.220.499
2iw84SPCyclin-dependent kinase 22.7.11.220.499
3r6xX84Cyclin-dependent kinase 22.7.11.220.499
3r9dX6BCyclin-dependent kinase 22.7.11.220.499
4ez30S0Cyclin-dependent kinase 22.7.11.220.499
3py0SU9Cyclin-dependent kinase 22.7.11.220.498
3s2pPMUCyclin-dependent kinase 22.7.11.220.497
4fx360KCyclin-dependent kinase 22.7.11.220.497
1g5sI17Cyclin-dependent kinase 22.7.11.220.495
1pxlCK4Cyclin-dependent kinase 22.7.11.220.495
1w0xOLOCyclin-dependent kinase 22.7.11.220.495
2a4lRRCCyclin-dependent kinase 22.7.11.220.495
2uzbC75Cyclin-dependent kinase 22.7.11.220.495
3fz1B98Cyclin-dependent kinase 22.7.11.220.495
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.494
3qqlX03Cyclin-dependent kinase 22.7.11.220.494
4eor4SPCyclin-dependent kinase 22.7.11.220.493
2a0cCK9Cyclin-dependent kinase 22.7.11.220.492
2wxvWXVCyclin-dependent kinase 22.7.11.220.492
1h0vUN4Cyclin-dependent kinase 22.7.11.220.491
3qzgX67Cyclin-dependent kinase 22.7.11.220.491
3r1qX75Cyclin-dependent kinase 22.7.11.220.491
1pxkCK3Cyclin-dependent kinase 22.7.11.220.490
2b54D05Cyclin-dependent kinase 22.7.11.220.490
2w1hL0FCyclin-dependent kinase 22.7.11.220.490
3r7iX9ICyclin-dependent kinase 22.7.11.220.490
3rpy27ZCyclin-dependent kinase 22.7.11.220.489
2i40BLZCyclin-dependent kinase 22.7.11.220.488
3r1sX73Cyclin-dependent kinase 22.7.11.220.488
3r7yZ04Cyclin-dependent kinase 22.7.11.220.488
2x1nX1NCyclin-dependent kinase 22.7.11.220.487
3wblPDYCyclin-dependent kinase 22.7.11.220.487
1h1s4SPCyclin-dependent kinase 22.7.11.220.486
1oiyN41Cyclin-dependent kinase 22.7.11.220.486
3qruX19Cyclin-dependent kinase 22.7.11.220.486
3unk0BYCyclin-dependent kinase 22.7.11.220.486
2btrU73Cyclin-dependent kinase 22.7.11.220.484
3qqgX06Cyclin-dependent kinase 22.7.11.220.484
1di8DTQCyclin-dependent kinase 22.7.11.220.483
1gii1PUCyclin-dependent kinase 22.7.11.220.483
2vtrLZBCyclin-dependent kinase 22.7.11.220.483
3dogNNNCyclin-dependent kinase 22.7.11.220.483
3lfnA27Cyclin-dependent kinase 22.7.11.220.483
3qqfX07Cyclin-dependent kinase 22.7.11.220.483
2vttLZDCyclin-dependent kinase 22.7.11.220.482
3nynSGVG protein-coupled receptor kinase 62.7.11.160.482
3pj8404Cyclin-dependent kinase 22.7.11.220.482
3roy22ZCyclin-dependent kinase 22.7.11.220.482
5cnoANPEpidermal growth factor receptor2.7.10.10.482
1urwI1PCyclin-dependent kinase 22.7.11.220.481
3ti1B49Cyclin-dependent kinase 22.7.11.220.481
1fvt106Cyclin-dependent kinase 22.7.11.220.480
1pkdUCNCyclin-dependent kinase 22.7.11.220.480
4lyn1YGCyclin-dependent kinase 22.7.11.220.480
4qmpDKISerine/threonine-protein kinase 242.7.11.10.480
2uzdC85Cyclin-dependent kinase 22.7.11.220.479
3rpr25ZCyclin-dependent kinase 22.7.11.220.479
1hckATPCyclin-dependent kinase 22.7.11.220.478
3ggfGVDSerine/threonine-protein kinase 26/0.478
2j9mPY8Cyclin-dependent kinase 22.7.11.220.477
3qtrX36Cyclin-dependent kinase 22.7.11.220.477
3r1yX76Cyclin-dependent kinase 22.7.11.220.477
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.477
2b55D31Cyclin-dependent kinase 22.7.11.220.476
3uli1N3Cyclin-dependent kinase 22.7.11.220.476
4zseANPEpidermal growth factor receptor2.7.10.10.476
1aq1STUCyclin-dependent kinase 22.7.11.220.475
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.475
2eufLQQCyclin-dependent kinase 62.7.11.220.474
3r83Z14Cyclin-dependent kinase 22.7.11.220.474
3r8pZ46Cyclin-dependent kinase 22.7.11.220.474
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.474
1gij2PUCyclin-dependent kinase 22.7.11.220.473
3c4xATPRhodopsin kinase/0.473
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.473
4qmlANPSerine/threonine-protein kinase 242.7.11.10.473
1pxoCK7Cyclin-dependent kinase 22.7.11.220.471
2exmZIPCyclin-dependent kinase 22.7.11.220.471
2xnbY8LCyclin-dependent kinase 22.7.11.220.471
3my5RFZCyclin-dependent kinase 22.7.11.220.471
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.470
1oi9N20Cyclin-dependent kinase 22.7.11.220.470
4erwSTUCyclin-dependent kinase 22.7.11.220.470
2bhhRYUCyclin-dependent kinase 22.7.11.220.469
2btsU32Cyclin-dependent kinase 22.7.11.220.469
2c5yMTWCyclin-dependent kinase 22.7.11.220.469
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.468
3c4wATPRhodopsin kinase/0.468
3qwkX62Cyclin-dependent kinase 22.7.11.220.468
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.468
2fvdLIACyclin-dependent kinase 22.7.11.220.467
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.467
3ig7EFPCyclin-dependent kinase 22.7.11.220.467
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.466
3rpo24ZCyclin-dependent kinase 22.7.11.220.465
1v0oINRCell division control protein 2 homolog2.7.11.220.463
2vtqLZACyclin-dependent kinase 22.7.11.220.463
4eok4SPCyclin-dependent kinase 22.7.11.220.463
4fkg4CKCyclin-dependent kinase 22.7.11.220.463
2c5nCK8Cyclin-dependent kinase 22.7.11.220.462
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.462
2b52D42Cyclin-dependent kinase 22.7.11.220.461
2izsBRQCasein kinase I isoform gamma-32.7.11.10.461
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.461
3nux3NVCyclin-dependent kinase 62.7.11.220.461
1vyzN5BCyclin-dependent kinase 22.7.11.220.460
3qqhX0ACyclin-dependent kinase 22.7.11.220.460
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.460
1eh4IC1Casein kinase I homolog 12.7.11.10.459
1xjdSTUProtein kinase C theta type2.7.11.130.459
3iok1P6Tyrosine-protein kinase JAK2/0.459
3qrtX14Cyclin-dependent kinase 22.7.11.220.459
3qziX72Cyclin-dependent kinase 22.7.11.220.459
3r28XA0Cyclin-dependent kinase 22.7.11.220.459
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
3r7eX88Cyclin-dependent kinase 22.7.11.220.458
3zep1NXTyrosine-protein kinase JAK32.7.10.20.458
2bkzSBCCyclin-dependent kinase 22.7.11.220.457
2c68CT6Cyclin-dependent kinase 22.7.11.220.457
2ds11CDCyclin-dependent kinase 22.7.11.220.457
2r3mSCXCyclin-dependent kinase 22.7.11.220.457
3r9oZ71Cyclin-dependent kinase 22.7.11.220.457
1ckpPVBCyclin-dependent kinase 22.7.11.220.456
1ke8LS4Cyclin-dependent kinase 22.7.11.220.456
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
2csnCKICasein kinase I homolog 12.7.11.10.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.456
1h1r6CPCyclin-dependent kinase 22.7.11.220.455
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.455
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.455
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.454
3pxyJWSCyclin-dependent kinase 22.7.11.220.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.453
3i60E86Mitogen-activated protein kinase 12.7.11.240.453
3qzfX66Cyclin-dependent kinase 22.7.11.220.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
1oiqHDUCyclin-dependent kinase 22.7.11.220.452
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.452
2pvjP44Casein kinase II subunit alpha2.7.11.10.452
4bcmT7ZCyclin-dependent kinase 22.7.11.220.452
4nj32KDCyclin-dependent kinase 22.7.11.220.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.451
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.451
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2wpa889Cyclin-dependent kinase 22.7.11.220.450
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.450
3rkb12ZCyclin-dependent kinase 22.7.11.220.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.450
2vu3LZECyclin-dependent kinase 22.7.11.220.449
2y9qANPMitogen-activated protein kinase 12.7.11.240.449
3ddqRRCCyclin-dependent kinase 22.7.11.220.449
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.449
1vyw292Cyclin-dependent kinase 22.7.11.220.448
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2wipP49Cyclin-dependent kinase 22.7.11.220.448
3orkAGSSerine/threonine protein kinase/0.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.448
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1unlRRCCyclin-dependent-like kinase 52.7.11.10.447
2f2cAP9Cyclin-dependent kinase 62.7.11.220.447
4aua4AUCyclin-dependent kinase 62.7.11.220.447
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3toh079Gag-Pol polyprotein2.7.7.490.446
4bbfO19Tyrosine-protein kinase JAK2/0.446
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.445
3tiz3TICyclin-dependent kinase 22.7.11.220.445
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.445
4ii5ADPCyclin-dependent kinase 22.7.11.220.445
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.445
1vikBAYGag-Pol polyprotein/0.444
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.444
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.444
5bqfNAPProbable hydroxyacid dehydrogenase protein/0.444
1m0b0ZQGag-Pol polyprotein3.4.23.160.443
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.443
2hc0AB2Protease/0.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
3gxlQIGTGF-beta receptor type-12.7.11.300.443
4ivb1J5Tyrosine-protein kinase JAK1/0.443
1phhFADp-hydroxybenzoate hydroxylase/0.442
2iw94SPCyclin-dependent kinase 22.7.11.220.442
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.442
5drdATPAurora kinase A2.7.11.10.442
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3lpkZ76Beta-secretase 13.4.23.460.441
3t8oATPRhodopsin kinase/0.441
4ez50RSCyclin-dependent kinase 62.7.11.220.441
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
1dj2GDPAdenylosuccinate synthetase, chloroplastic/0.440
2cchATPCyclin-dependent kinase 22.7.11.220.440
2r26CMCCitrate synthase2.3.3.160.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
4btjATPTau-tubulin kinase 12.7.11.10.440
4qgiROCGag-Pol polyprotein3.4.23.160.440