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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.146

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1461.000
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.603
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.552
4hwkNAPSepiapterin reductase1.1.1.1530.551
1xg5NAPDehydrogenase/reductase SDR family member 11/0.536
4j7xNAPSepiapterin reductase1.1.1.1530.534
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.529
4j7uNAPSepiapterin reductase1.1.1.1530.526
4qecNAPElxO/0.524
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.523
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.516
1ae1NAPTropinone reductase 1/0.515
1xkqNDPUncharacterized protein/0.506
1w4zNAPPutative ketoacyl reductase1.3.10.504
4dc1NDPPutative ketoacyl reductase1.3.10.503
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.502
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.502
3l77NJPShort-chain alcohol dehydrogenase/0.498
3sjuNDPKeto reductase/0.497
1n5dNDPCarbonyl reductase [NADPH] 1/0.496
4bmvNAPShort-chain dehydrogenase/0.495
3gy0NAPNAD(P)-dependent oxidoreductase/0.493
1oaaNAPSepiapterin reductase1.1.1.1530.492
3p19NDPPutative blue fluorescent protein/0.490
1x7gNAPPutative ketoacyl reductase1.3.10.488
3qrwNDPPutative ketoacyl reductase1.3.10.486
1ipeNDPTropinone reductase 21.1.1.2360.484
1wntNAPL-xylulose reductase1.1.1.100.484
3tn7NJPShort-chain alcohol dehydrogenase/0.484
1snyNAPLD36273p/0.483
3toxNAPPutative oxidoreductase/0.483
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.483
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.480
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.478
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.475
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.474
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.474
2yutNAPPutative short-chain oxidoreductase/0.474
1g6kNADGlucose 1-dehydrogenase1.1.1.470.473
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
5idwNAPShort-chain dehydrogenase/reductase SDR/0.470
3f1kNAPUncharacterized oxidoreductase YciK10.468
1x7hNDPPutative ketoacyl reductase1.3.10.467
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.465
4qedNAPElxO/0.464
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.462
3ai3NDPNADPH-sorbose reductase/0.461
3uceNDPDehydrogenase/0.461
5jlaNADPutative short-chain dehydrogenase/reductase/0.461
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.460
3d3wNAPL-xylulose reductase1.1.1.100.459
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.457
1pr9NAPL-xylulose reductase1.1.1.100.456
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.456
2dteNAIGlucose 1-dehydrogenase related protein/0.454
2jahNDPClavaldehyde dehydrogenase/0.454
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.449
3lqfNADGalactitol dehydrogenase/0.449
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.446
3bmoNAPPteridine reductase/0.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.446
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.444
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
2bd0NAPSepiapterin reductase/0.442
3ai2NDPNADPH-sorbose reductase/0.441
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.441
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.440