sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xls | REA | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.629 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.616 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.612 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.612 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.611 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.607 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.602 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.601 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.599 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.591 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.586 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.586 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.581 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.581 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.570 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.568 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.568 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.567 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.560 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.555 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.545 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.537 | |
| 3p9t | TCL | Repressor | / | 0.499 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.496 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.490 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.489 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.487 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.483 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.479 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.477 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.477 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.477 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.476 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.476 | |
| 3h1j | SMA | Cytochrome b | / | 0.476 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.475 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.474 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.472 | |
| 3aba | FLI | Cytochrome P450 | / | 0.472 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.472 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.472 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.472 | |
| 3v4e | COA | Putative acetyltransferase SACOL2570 | 2.3.1 | 0.471 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.470 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.470 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.470 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.469 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.468 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.468 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.468 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.467 | |
| 4l8u | 9AZ | Serum albumin | / | 0.467 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.467 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.466 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.466 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.466 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.465 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 1ysx | 4EB | Serum albumin | / | 0.464 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2wpx | ACO | Orf14 | / | 0.464 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.464 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.464 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.464 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.463 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.463 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.462 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.462 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.462 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.462 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.462 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.461 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.461 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.461 | |
| 2cdu | FAD | NADH oxidase | / | 0.460 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.460 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.460 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.460 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.459 | |
| 2p15 | EZT | Estrogen receptor | / | 0.459 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.459 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.459 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.459 | |
| 3clx | X22 | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.459 | |
| 3sh0 | SAX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.459 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.459 | |
| 5bn3 | ADP | NEQ263 | / | 0.459 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.458 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.458 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.458 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.458 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.458 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.458 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.457 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.457 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.457 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.457 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.457 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.456 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.456 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.456 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.456 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3zux | TCH | Transporter | / | 0.456 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.456 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.456 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.456 | |
| 1fml | RTL | Retinol dehydratase | / | 0.455 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.455 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.455 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.455 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.455 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.455 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 2qjy | SMA | Cytochrome b | / | 0.454 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.454 | |
| 3lu8 | IQX | Serum albumin | / | 0.454 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.454 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1ezv | SMA | Cytochrome b | / | 0.453 | |
| 1pp9 | SMA | Cytochrome b | / | 0.453 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.453 | |
| 2wpw | ACO | Orf14 | / | 0.453 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.453 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.453 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.453 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.453 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.452 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 3qly | 55V | Uncharacterized protein | / | 0.452 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.452 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.451 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.451 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.451 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.451 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.451 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.450 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.450 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.450 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.450 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.450 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4inb | 1F6 | Gag protein | / | 0.450 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4okt | 198 | Androgen receptor | / | 0.450 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.449 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 2ibz | SMA | Cytochrome b | / | 0.449 | |
| 2rkf | AB1 | Pol protein | / | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.449 | |
| 3dol | GWI | Pol protein | / | 0.449 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.449 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.449 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1kb9 | SMA | Cytochrome b | / | 0.448 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.448 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.448 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.448 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.448 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.448 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.448 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.448 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.448 | |
| 4olm | 198 | Androgen receptor | / | 0.448 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1rti | HEF | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.447 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.447 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2xnn | 430 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 2y3s | TIR | TamL | / | 0.446 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.446 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.446 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.446 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.446 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.446 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4o4e | ATP | Kinase | / | 0.446 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.446 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.446 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.445 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.445 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.444 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3cse | N22 | Uncharacterized protein | / | 0.444 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.444 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.444 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.444 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.444 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.444 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.443 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.443 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.443 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.443 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.443 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4la0 | 198 | Serum albumin | / | 0.443 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.443 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.443 | |
| 5doz | NDP | JamJ | / | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.442 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.442 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.442 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.442 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.442 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ewr | APR | Replicase polyprotein 1a | 3.4.22 | 0.442 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.442 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.442 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.442 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.441 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.441 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.441 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4iae | 1DX | Alr2278 protein | / | 0.441 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.441 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.441 | |
| 4u9v | ACO | N-alpha-acetyltransferase 40 | 2.3.1 | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1jg0 | DDT | Thymidylate synthase | / | 0.440 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.440 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.440 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.440 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.440 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2b5j | 3AC | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.440 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.440 | |
| 3cx5 | SMA | Cytochrome b | / | 0.440 | |
| 3cxh | SMA | Cytochrome b | / | 0.440 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.440 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.440 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.440 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.440 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.440 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.440 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.440 |