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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xgjHTCBeta-lactamase3.5.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xgjHTCBeta-lactamase3.5.2.61.000
1xgiNSTBeta-lactamase3.5.2.60.627
2r9xWH6Beta-lactamase3.5.2.60.592
2r9w23CBeta-lactamase3.5.2.60.564
1l2sSTCBeta-lactamase3.5.2.60.538
2pu2DK2Beta-lactamase3.5.2.60.506
1rneC60Renin3.4.23.150.473
5a3cNADSIR2 family protein/0.473
5a3bAPRSIR2 family protein/0.468
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.464
3b70NAPEnoyl reductase LovC10.461
2igoFADPyranose 2-oxidase/0.460
1w6hTITPlasmepsin-23.4.23.390.459
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.457
3f63GTXGlutathione transferase GST1-4/0.457
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.455
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.455
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.455
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.454
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.454
5dldUD1UDP-N-Acetylglucosamine 2-epimerase/0.453
1bil0IURenin3.4.23.150.452
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.452
3d91REMRenin3.4.23.150.452
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.451
2g247IGRenin3.4.23.150.451
4ambDUDPutative glycosyl transferase/0.451
2hpvFMNFMN-dependent NADH-azoreductase1.70.449
2v16C47Renin3.4.23.150.449
4d89BXDBeta-secretase 13.4.23.460.449
3clsFADElectron transfer flavoprotein subunit alpha/0.448
3lpjZ75Beta-secretase 13.4.23.460.448
2wf4ZY4Beta-secretase 13.4.23.460.447
3nl6ACPUncharacterized protein/0.446
3r7kFDAProbable acyl CoA dehydrogenase/0.446
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3q43D66M1 family aminopeptidase3.4.110.445
3vswR31Renin3.4.23.150.445
3gqvNAPEnoyl reductase LovC10.444
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.444
3vsxR32Renin3.4.23.150.443
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4ybnFADFlavin-nucleotide-binding protein/0.442
2i4qUA4Renin3.4.23.150.441
1geeNADGlucose 1-dehydrogenase1.1.1.470.440
4q71FADBifunctional protein PutA/0.440
5dcyNAPIridoid synthase1.3.1.990.440