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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xgiNSTBeta-lactamase3.5.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xgiNSTBeta-lactamase3.5.2.61.000
2r9xWH6Beta-lactamase3.5.2.60.669
1xgjHTCBeta-lactamase3.5.2.60.650
2r9w23CBeta-lactamase3.5.2.60.588
2pu2DK2Beta-lactamase3.5.2.60.559
1l2sSTCBeta-lactamase3.5.2.60.522
2igoFADPyranose 2-oxidase/0.480
1w6hTITPlasmepsin-23.4.23.390.477
2fj1CTCTetracycline repressor protein class D/0.477
3d91REMRenin3.4.23.150.477
2fznFADBifunctional protein PutA1.5.5.20.475
2hpvFMNFMN-dependent NADH-azoreductase1.70.474
2ignFADPyranose 2-oxidase/0.473
2zynBCDPeriplasmic binding protein/0.462
1cf3FADGlucose oxidase1.1.3.40.460
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.460
1rneC60Renin3.4.23.150.458
3bg7FADPyranose 2-oxidase/0.458
1qrpHH0Pepsin A-43.4.23.10.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.455
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.455
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.455
2pncCLUPrimary amine oxidase, liver isozyme/0.455
3kb1ADPIron-sulfur cluster carrier protein/0.455
1galFADGlucose oxidase1.1.3.40.454
2v16C47Renin3.4.23.150.454
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.454
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.454
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1obnASVIsopenicillin N synthase1.21.3.10.453
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
2xpuTDCTetracycline repressor protein class D/0.453
3lpkZ76Beta-secretase 13.4.23.460.453
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.453
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.452
4mihFADPyranose 2-oxidase1.1.3.100.452
2givACOHistone acetyltransferase KAT8/0.451
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.451
3f63GTXGlutathione transferase GST1-4/0.451
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.451
3w8eNAD3-hydroxybutyrate dehydrogenase/0.451
4jicFMNGTN Reductase/0.451
1d0mBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.450
2a7r5GPGMP reductase 2/0.450
3q43D66M1 family aminopeptidase3.4.110.450
4egbNADdTDP-glucose 4,6-dehydratase/0.450
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.449
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.449
2abbFMNPentaerythritol tetranitrate reductase/0.449
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.449
3vyfVYFRenin3.4.23.150.449
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
1hb1OCVIsopenicillin N synthase1.21.3.10.448
1t4u81AProthrombin3.4.21.50.448
2gjlFMNNitronate monooxygenase1.13.12.160.448
3kybFADUDP-galactopyranose mutase5.4.99.90.448
3lpiZ74Beta-secretase 13.4.23.460.448
5a0112VO-glycosyltransferase/0.448
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.447
1tiqCOASpermidine/spermine N(1)-acetyltransferase/0.447
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
3ahn3A1Oligopeptidase/0.447
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.447
3toxNAPPutative oxidoreductase/0.447
5a3bAPRSIR2 family protein/0.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1xe55FEPlasmepsin-23.4.23.390.446
3ai3NDPNADPH-sorbose reductase/0.446
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.446
3ukoNADAlcohol dehydrogenase class-3/0.446
4ambDUDPutative glycosyl transferase/0.446
4q71FADBifunctional protein PutA/0.446
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.446
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.445
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.445
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.445
2i4qUA4Renin3.4.23.150.445
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.445
3oqfS51Renin3.4.23.150.445
4blrUTPNTPase P4/0.445
4dpf0LGBeta-secretase 13.4.23.460.445
1q84TZ4Acetylcholinesterase3.1.1.70.444
2fiwACOGCN5-related N-acetyltransferase:Aminotransferase, class-II/0.444
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.444
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.444
1bil0IURenin3.4.23.150.443
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.443
3vswR31Renin3.4.23.150.443
4ey7E20Acetylcholinesterase3.1.1.70.443
2g247IGRenin3.4.23.150.442
2vkeTACTetracycline repressor protein class D/0.442
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.442
2iko7IGRenin3.4.23.150.441
3ai2NDPNADPH-sorbose reductase/0.441
3dr8ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase/0.441
3hwrNDP2-dehydropantoate 2-reductase/0.441
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.441
3vucHHERenin3.4.23.150.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4qi4FADCellobiose dehydrogenase/0.441
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.441
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.440
2ikuLIYRenin3.4.23.150.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.440
4yxm2BADNA integrity scanning protein DisA/0.440
4z26FADPutative GMC-type oxidoreductase R13510.440