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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1wur8DGGTP cyclohydrolase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1wur8DGGTP cyclohydrolase 1/1.000
1wuq8GTGTP cyclohydrolase 1/0.558
4du6GTPGTP cyclohydrolase 1/0.495
1obnASVIsopenicillin N synthase1.21.3.10.493
1a9cGTPGTP cyclohydrolase 13.5.4.160.475
5irnADPNucleotide binding oligomerization domain containing 2/0.472
4oztP1AEcdysone receptor, putative/0.459
2y60M8FIsopenicillin N synthase1.21.3.10.458
2g8yNADHydroxycarboxylate dehydrogenase B/0.457
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.456
2q0lNAPThioredoxin reductase1.8.1.90.456
1oc1ASVIsopenicillin N synthase1.21.3.10.453
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.451
4cukNAID-lactate dehydrogenase/0.451
2cbrA80Cellular retinoic acid-binding protein 1/0.447
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.447
2gesCOKPantothenate kinase2.7.1.330.446
1a8rGTPGTP cyclohydrolase 13.5.4.160.445
3zoiM2WIsopenicillin N synthase1.21.3.10.445
3ddw055Glycogen phosphorylase, liver form2.4.1.10.444
3rfaSAMDual-specificity RNA methyltransferase RlmN/0.444
4isk1JYThymidylate synthase/0.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4pzrCOAHistone acetyltransferase p300/0.441
2vbpVB1Isopenicillin N synthase1.21.3.10.440
4b5dSW4Achbp/0.440