sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 1.000 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.629 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.475 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.466 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.455 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.450 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.450 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.444 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.441 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.440 |