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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1vyw292Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1vyw292Cyclin-dependent kinase 22.7.11.221.000
2wpa889Cyclin-dependent kinase 22.7.11.220.623
2wihP48Cyclin-dependent kinase 22.7.11.220.599
3ddpRC8Cyclin-dependent kinase 22.7.11.220.587
3ddqRRCCyclin-dependent kinase 22.7.11.220.574
3r73X87Cyclin-dependent kinase 22.7.11.220.563
1h1r6CPCyclin-dependent kinase 22.7.11.220.561
2wxvWXVCyclin-dependent kinase 22.7.11.220.561
4bcpT3CCyclin-dependent kinase 22.7.11.220.559
1unlRRCCyclin-dependent-like kinase 52.7.11.10.557
1h1s4SPCyclin-dependent kinase 22.7.11.220.554
1e9hINRCyclin-dependent kinase 22.7.11.220.553
1oi9N20Cyclin-dependent kinase 22.7.11.220.552
3lfnA27Cyclin-dependent kinase 22.7.11.220.552
2r64740Cyclin-dependent kinase 22.7.11.220.550
3qqfX07Cyclin-dependent kinase 22.7.11.220.549
3s2pPMUCyclin-dependent kinase 22.7.11.220.549
1ke6LS2Cyclin-dependent kinase 22.7.11.220.548
2bkzSBCCyclin-dependent kinase 22.7.11.220.547
3qxpX64Cyclin-dependent kinase 22.7.11.220.546
1oguST8Cyclin-dependent kinase 22.7.11.220.545
1oiyN41Cyclin-dependent kinase 22.7.11.220.543
3roy22ZCyclin-dependent kinase 22.7.11.220.543
4eor4SPCyclin-dependent kinase 22.7.11.220.543
2b52D42Cyclin-dependent kinase 22.7.11.220.541
3qu0X40Cyclin-dependent kinase 22.7.11.220.539
3r1yX76Cyclin-dependent kinase 22.7.11.220.539
3rk507ZCyclin-dependent kinase 22.7.11.220.539
4fx360KCyclin-dependent kinase 22.7.11.220.537
3rpv26ZCyclin-dependent kinase 22.7.11.220.535
3qzhX69Cyclin-dependent kinase 22.7.11.220.534
3r6xX84Cyclin-dependent kinase 22.7.11.220.533
3r7yZ04Cyclin-dependent kinase 22.7.11.220.533
3r9dX6BCyclin-dependent kinase 22.7.11.220.532
2iw84SPCyclin-dependent kinase 22.7.11.220.531
2iw94SPCyclin-dependent kinase 22.7.11.220.531
2r3p3SCCyclin-dependent kinase 22.7.11.220.530
3qtzX42Cyclin-dependent kinase 22.7.11.220.530
3ral04ZCyclin-dependent kinase 22.7.11.220.530
4bcmT7ZCyclin-dependent kinase 22.7.11.220.530
4fkq42KCyclin-dependent kinase 22.7.11.220.530
1w0xOLOCyclin-dependent kinase 22.7.11.220.529
2fvdLIACyclin-dependent kinase 22.7.11.220.529
3rm719ZCyclin-dependent kinase 22.7.11.220.529
1gih1PUCyclin-dependent kinase 22.7.11.220.528
1ke9LS5Cyclin-dependent kinase 22.7.11.220.528
2a0cCK9Cyclin-dependent kinase 22.7.11.220.528
3qwkX62Cyclin-dependent kinase 22.7.11.220.528
3sqq99ZCyclin-dependent kinase 22.7.11.220.528
3qxoX65Cyclin-dependent kinase 22.7.11.220.527
4eok4SPCyclin-dependent kinase 22.7.11.220.527
1di8DTQCyclin-dependent kinase 22.7.11.220.526
2w06FRVCyclin-dependent kinase 22.7.11.220.524
3rjc06ZCyclin-dependent kinase 22.7.11.220.524
3rpo24ZCyclin-dependent kinase 22.7.11.220.524
4lyn1YGCyclin-dependent kinase 22.7.11.220.524
1oitHDTCyclin-dependent kinase 22.7.11.220.522
3ig7EFPCyclin-dependent kinase 22.7.11.220.522
3iggEFQCyclin-dependent kinase 22.7.11.220.522
3r7vZ02Cyclin-dependent kinase 22.7.11.220.522
1fvt106Cyclin-dependent kinase 22.7.11.220.521
2btsU32Cyclin-dependent kinase 22.7.11.220.521
3ezrEZRCyclin-dependent kinase 22.7.11.220.521
2j9mPY8Cyclin-dependent kinase 22.7.11.220.520
3pj8404Cyclin-dependent kinase 22.7.11.220.520
3rk708ZCyclin-dependent kinase 22.7.11.220.520
3rm618ZCyclin-dependent kinase 22.7.11.220.520
1v1k3FPCyclin-dependent kinase 22.7.11.220.518
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.518
3r9hZ67Cyclin-dependent kinase 22.7.11.220.518
3rk909ZCyclin-dependent kinase 22.7.11.220.518
3rni21ZCyclin-dependent kinase 22.7.11.220.517
1h1q2A6Cyclin-dependent kinase 22.7.11.220.516
2w05FRTCyclin-dependent kinase 22.7.11.220.516
1oiqHDUCyclin-dependent kinase 22.7.11.220.515
2r3kSCQCyclin-dependent kinase 22.7.11.220.515
3lfqA28Cyclin-dependent kinase 22.7.11.220.515
3r7eX88Cyclin-dependent kinase 22.7.11.220.515
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.514
4ek816KCyclin-dependent kinase 22.7.11.220.514
3lfsA07Cyclin-dependent kinase 22.7.11.220.513
4bgh3I6Cyclin-dependent kinase 22.7.11.220.513
2b55D31Cyclin-dependent kinase 22.7.11.220.512
2c4g514Cyclin-dependent kinase 22.7.11.220.512
1ke7LS3Cyclin-dependent kinase 22.7.11.220.511
3r83Z14Cyclin-dependent kinase 22.7.11.220.511
3raiX85Cyclin-dependent kinase 22.7.11.220.511
4erwSTUCyclin-dependent kinase 22.7.11.220.509
1g5sI17Cyclin-dependent kinase 22.7.11.220.508
1y91CT9Cyclin-dependent kinase 22.7.11.220.508
3rak03ZCyclin-dependent kinase 22.7.11.220.508
3tnwF18Cyclin-dependent kinase 22.7.11.220.508
2uzoC62Cyclin-dependent kinase 22.7.11.220.507
3qwjX6ACyclin-dependent kinase 22.7.11.220.507
4fkw62KCyclin-dependent kinase 22.7.11.220.507
3my5RFZCyclin-dependent kinase 22.7.11.220.506
3qzgX67Cyclin-dependent kinase 22.7.11.220.506
3s1h56ZCyclin-dependent kinase 22.7.11.220.506
4ez30S0Cyclin-dependent kinase 22.7.11.220.506
2btrU73Cyclin-dependent kinase 22.7.11.220.505
2c6o4SPCyclin-dependent kinase 22.7.11.220.505
3r7iX9ICyclin-dependent kinase 22.7.11.220.505
2cchATPCyclin-dependent kinase 22.7.11.220.504
3s0o50ZCyclin-dependent kinase 22.7.11.220.504
2r3lSCWCyclin-dependent kinase 22.7.11.220.503
4ek610KCyclin-dependent kinase 22.7.11.220.503
1vyzN5BCyclin-dependent kinase 22.7.11.220.502
3r1qX75Cyclin-dependent kinase 22.7.11.220.502
3r28XA0Cyclin-dependent kinase 22.7.11.220.502
4qmpDKISerine/threonine-protein kinase 242.7.11.10.502
1fvv107Cyclin-dependent kinase 22.7.11.220.501
3qziX72Cyclin-dependent kinase 22.7.11.220.501
3rmf20ZCyclin-dependent kinase 22.7.11.220.501
4eol1ROCyclin-dependent kinase 22.7.11.220.501
4fkr45KCyclin-dependent kinase 22.7.11.220.501
3qqkX02Cyclin-dependent kinase 22.7.11.220.500
3qtuX44Cyclin-dependent kinase 22.7.11.220.500
4fkv61KCyclin-dependent kinase 22.7.11.220.500
1ckpPVBCyclin-dependent kinase 22.7.11.220.499
1ke5LS1Cyclin-dependent kinase 22.7.11.220.499
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.499
3r8lZ30Cyclin-dependent kinase 22.7.11.220.499
2vu3LZECyclin-dependent kinase 22.7.11.220.498
2x1nX1NCyclin-dependent kinase 22.7.11.220.498
3r1sX73Cyclin-dependent kinase 22.7.11.220.498
4acm7YGCyclin-dependent kinase 22.7.11.220.498
4cfnJYMCyclin-dependent kinase 22.7.11.220.498
4fki09KCyclin-dependent kinase 22.7.11.220.498
2uzdC85Cyclin-dependent kinase 22.7.11.220.497
3bhtMFRCyclin-dependent kinase 22.7.11.220.496
2c5nCK8Cyclin-dependent kinase 22.7.11.220.495
2r3r6SCCyclin-dependent kinase 22.7.11.220.495
2c6tDT5Cyclin-dependent kinase 22.7.11.220.494
3r71X86Cyclin-dependent kinase 22.7.11.220.494
3unk0BYCyclin-dependent kinase 22.7.11.220.494
4fkpLS5Cyclin-dependent kinase 22.7.11.220.494
2bhhRYUCyclin-dependent kinase 22.7.11.220.493
2vttLZDCyclin-dependent kinase 22.7.11.220.493
2r3mSCXCyclin-dependent kinase 22.7.11.220.492
4fkj11KCyclin-dependent kinase 22.7.11.220.492
1pxmCK5Cyclin-dependent kinase 22.7.11.220.491
3r7uX96Cyclin-dependent kinase 22.7.11.220.491
1h1pCMGCyclin-dependent kinase 22.7.11.220.488
1oiuN76Cyclin-dependent kinase 22.7.11.220.488
2r3o2SCCyclin-dependent kinase 22.7.11.220.488
3ql8X01Cyclin-dependent kinase 22.7.11.220.488
4bcqTJFCyclin-dependent kinase 22.7.11.220.488
2c6iDT1Cyclin-dependent kinase 22.7.11.220.487
3ezvEZVCyclin-dependent kinase 22.7.11.220.487
3r8pZ46Cyclin-dependent kinase 22.7.11.220.487
1urwI1PCyclin-dependent kinase 22.7.11.220.486
2i40BLZCyclin-dependent kinase 22.7.11.220.486
2wotZZGTGF-beta receptor type-12.7.11.300.485
4fkt48KCyclin-dependent kinase 22.7.11.220.485
1finATPCyclin-dependent kinase 22.7.11.220.484
1ke8LS4Cyclin-dependent kinase 22.7.11.220.484
1p2a5BNCyclin-dependent kinase 22.7.11.220.484
2r3iSCFCyclin-dependent kinase 22.7.11.220.484
2vv9IM9Cyclin-dependent kinase 22.7.11.220.484
3dogNNNCyclin-dependent kinase 22.7.11.220.484
2a4lRRCCyclin-dependent kinase 22.7.11.220.483
3rkb12ZCyclin-dependent kinase 22.7.11.220.483
4bcoT6QCyclin-dependent kinase 22.7.11.220.482
4eos1ROCyclin-dependent kinase 22.7.11.220.482
2w17I19Cyclin-dependent kinase 22.7.11.220.481
3qx2X63Cyclin-dependent kinase 22.7.11.220.481
1ykr628Cyclin-dependent kinase 22.7.11.220.480
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.480
2uznC96Cyclin-dependent kinase 22.7.11.220.479
4kd11QKCyclin-dependent kinase 22.7.11.220.479
3qruX19Cyclin-dependent kinase 22.7.11.220.478
3r8zZ63Cyclin-dependent kinase 22.7.11.220.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.478
4bcnT9NCyclin-dependent kinase 22.7.11.220.477
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.475
3qqhX0ACyclin-dependent kinase 22.7.11.220.475
1pkdUCNCyclin-dependent kinase 22.7.11.220.474
2r3fSC8Cyclin-dependent kinase 22.7.11.220.474
3qzfX66Cyclin-dependent kinase 22.7.11.220.474
4fkg4CKCyclin-dependent kinase 22.7.11.220.474
1r78FMDCyclin-dependent kinase 22.7.11.220.473
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.473
1gy3ATPCyclin-dependent kinase 22.7.11.220.472
1w8cN69Cyclin-dependent kinase 22.7.11.220.472
2vtsLZCCyclin-dependent kinase 22.7.11.220.472
2xmyCDKCyclin-dependent kinase 22.7.11.220.472
3qrtX14Cyclin-dependent kinase 22.7.11.220.472
1pxoCK7Cyclin-dependent kinase 22.7.11.220.471
3qtxX43Cyclin-dependent kinase 22.7.11.220.471
1gii1PUCyclin-dependent kinase 22.7.11.220.470
1h0w207Cyclin-dependent kinase 22.7.11.220.470
1pxlCK4Cyclin-dependent kinase 22.7.11.220.470
2v7a627Tyrosine-protein kinase ABL12.7.10.20.470
3unj0BXCyclin-dependent kinase 22.7.11.220.470
1v0oINRCell division control protein 2 homolog2.7.11.220.469
2uzeC95Cyclin-dependent kinase 22.7.11.220.469
3qqlX03Cyclin-dependent kinase 22.7.11.220.469
2duv371Cyclin-dependent kinase 22.7.11.220.468
3rahO1ZCyclin-dependent kinase 22.7.11.220.468
3ti1B49Cyclin-dependent kinase 22.7.11.220.468
3uli1N3Cyclin-dependent kinase 22.7.11.220.468
1gij2PUCyclin-dependent kinase 22.7.11.220.467
1oirHDYCyclin-dependent kinase 22.7.11.220.467
2xnbY8LCyclin-dependent kinase 22.7.11.220.467
3qtwX3ACyclin-dependent kinase 22.7.11.220.467
2bheBRYCyclin-dependent kinase 22.7.11.220.466
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.466
4eoi1ROCyclin-dependent kinase 22.7.11.220.466
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.466
2r3gSC9Cyclin-dependent kinase 22.7.11.220.465
3r9oZ71Cyclin-dependent kinase 22.7.11.220.465
3rpr25ZCyclin-dependent kinase 22.7.11.220.465
3sheI85MAP kinase-activated protein kinase 32.7.11.10.465
3sw418KCyclin-dependent kinase 22.7.11.220.465
1dm2HMDCyclin-dependent kinase 22.7.11.220.464
2b54D05Cyclin-dependent kinase 22.7.11.220.464
3sw719KCyclin-dependent kinase 22.7.11.220.463
3wblPDYCyclin-dependent kinase 22.7.11.220.463
1aq1STUCyclin-dependent kinase 22.7.11.220.462
2w1hL0FCyclin-dependent kinase 22.7.11.220.462
4eomATPCyclin-dependent kinase 22.7.11.220.462
1pxkCK3Cyclin-dependent kinase 22.7.11.220.461
1pyePM1Cyclin-dependent kinase 22.7.11.220.461
2uzlC94Cyclin-dependent kinase 22.7.11.220.461
3r8uZ31Cyclin-dependent kinase 22.7.11.220.461
4eon1ROCyclin-dependent kinase 22.7.11.220.461
2c6mDT5Cyclin-dependent kinase 22.7.11.220.459
3fz1B98Cyclin-dependent kinase 22.7.11.220.459
3le62BZCyclin-dependent kinase 22.7.11.220.459
3nux3NVCyclin-dependent kinase 62.7.11.220.459
4eop1ROCyclin-dependent kinase 22.7.11.220.458
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.457
2r3jSCJCyclin-dependent kinase 22.7.11.220.457
2uzbC75Cyclin-dependent kinase 22.7.11.220.457
3qtrX36Cyclin-dependent kinase 22.7.11.220.456
4gmy0X5Tyrosine-protein kinase JAK2/0.456
3r8vZ62Cyclin-dependent kinase 22.7.11.220.455
5e8wSTUTGF-beta receptor type-12.7.11.300.454
2c69CT8Cyclin-dependent kinase 22.7.11.220.453
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3s00Z60Cyclin-dependent kinase 22.7.11.220.453
4bgg844Activin receptor type-12.7.11.300.453
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1unhIXMCyclin-dependent-like kinase 52.7.11.10.452
3qtqX35Cyclin-dependent kinase 22.7.11.220.452
2b53D23Cyclin-dependent kinase 22.7.11.220.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
5aacVGHALK tyrosine kinase receptor2.7.10.10.451
3tiz3TICyclin-dependent kinase 22.7.11.220.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
1pxpCK8Cyclin-dependent kinase 22.7.11.220.449
2r3q5SCCyclin-dependent kinase 22.7.11.220.449
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
3nup3NUCyclin-dependent kinase 62.7.11.220.447
3r9nZ68Cyclin-dependent kinase 22.7.11.220.447
3rpy27ZCyclin-dependent kinase 22.7.11.220.447
4fko20KCyclin-dependent kinase 22.7.11.220.446
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ic7ANPMitogen-activated protein kinase 72.7.11.240.445
1e1xNW1Cyclin-dependent kinase 22.7.11.220.444
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.444
3qtsX46Cyclin-dependent kinase 22.7.11.220.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4fks46KCyclin-dependent kinase 22.7.11.220.444
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.443
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.443
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.443
2c5yMTWCyclin-dependent kinase 22.7.11.220.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
3lq5SLQCyclin-dependent kinase 92.7.11.220.442
3pxyJWSCyclin-dependent kinase 22.7.11.220.442
4qmzB49Serine/threonine-protein kinase 242.7.11.10.442
2vtqLZACyclin-dependent kinase 22.7.11.220.441
2xngA0HAurora kinase A2.7.11.10.441
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.441
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.441
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4e4m0NHTyrosine-protein kinase JAK2/0.440