sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 1.000 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.574 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.508 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.504 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.498 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.495 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.495 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.492 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.491 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.490 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.489 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.486 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.486 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.486 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.485 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.485 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.485 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.484 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.483 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.482 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.482 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.482 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.481 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.481 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.480 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.480 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.479 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.476 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.476 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.476 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.474 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.473 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.473 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.473 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.473 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.472 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.471 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.469 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.469 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.469 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.469 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.468 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.468 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.467 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.467 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.467 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.467 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.467 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.466 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.466 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 4n1g | CEI | Obelin | / | 0.466 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.466 | |
| 1c7o | PPG | Hemolysin | / | 0.465 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.465 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.465 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.465 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.465 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.465 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.464 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.464 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 3f0r | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.464 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.464 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.463 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.463 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.463 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.463 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.462 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.462 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.462 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.461 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.461 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.460 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.460 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.460 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.459 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.459 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.459 | |
| 4xwt | U5P | Ribonuclease J | / | 0.459 | |
| 1fml | RTL | Retinol dehydratase | / | 0.458 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.458 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.458 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.458 | |
| 4kxj | P34 | Nucleoprotein | / | 0.458 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.458 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.458 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.457 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.456 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.456 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1ppj | ANY | Cytochrome b | / | 0.456 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.456 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.456 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.455 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.455 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 1t69 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.454 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.454 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.454 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.454 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.454 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.454 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.454 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.454 | |
| 1gsf | EAA | Glutathione S-transferase A1 | 2.5.1.18 | 0.453 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.453 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.453 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.453 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.453 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.452 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.452 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.452 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1zdw | FLV | Prenyltransferase | / | 0.451 | |
| 2xlr | NAP | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.451 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.450 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.450 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.450 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4phl | PIL | Phosphodiesterase | / | 0.450 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.450 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.449 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.449 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.449 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3fbu | COA | Acetyltransferase, GNAT family | / | 0.449 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4hcy | 0YN | Transketolase | / | 0.449 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.449 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.448 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.448 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.448 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2po3 | T4K | 4-dehydrase | / | 0.447 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.447 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.446 | |
| 2bxo | OPB | Serum albumin | / | 0.446 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.446 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.446 | |
| 3f90 | FMN | Flavodoxin | / | 0.446 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 4aza | MGO | Eukaryotic translation initiation factor 4E | / | 0.446 | |
| 4hai | I23 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.446 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.445 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.445 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.445 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.445 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.445 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.445 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1xh5 | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2yye | APC | Selenide, water dikinase | 2.7.9.3 | 0.444 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3c1o | NAP | Eugenol synthase | / | 0.444 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.444 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1swt | BTN | Streptavidin | / | 0.443 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3klb | FMN | Uncharacterized protein | / | 0.443 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.443 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 4k7y | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.442 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.442 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4rxq | DUT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.442 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.441 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2zw5 | COA | Bleomycin acetyltransferase | / | 0.441 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.441 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.441 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.441 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.440 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.440 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.440 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.440 |