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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1vi2NADQuinate/shikimate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1vi2NADQuinate/shikimate dehydrogenase/1.000
1o9bNAIQuinate/shikimate dehydrogenase/0.642
3t4eNADQuinate/shikimate dehydrogenase/0.606
2ev9NAPShikimate dehydrogenase (NADP(+))/0.555
1npdNADQuinate/shikimate dehydrogenase/0.544
2cy0NAPShikimate dehydrogenase (NADP(+))/0.538
3tnlNADShikimate dehydrogenase (NADP(+))/0.521
1nvtNAPShikimate dehydrogenase (NADP(+))/0.514
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.511
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.506
2hk9NAPShikimate dehydrogenase (NADP(+))/0.496
1nzdUPGDNA beta-glucosyltransferase/0.484
3tozNADShikimate dehydrogenase (NADP(+))/0.483
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.479
3phiNDPShikimate dehydrogenase (NADP(+))/0.479
3gwfNAPCyclohexanone monooxygenase/0.454
5cwa0GAAnthranilate synthase component 14.1.3.270.452
1u3cFADCryptochrome-1/0.447
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.447
2vn1FK5Peptidylprolyl isomerase/0.446
2ou5FMNPyridoxamine 5'-phosphate oxidase-related FMN-binding protein/0.444
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3nmpPYVAbscisic acid receptor PYL2/0.441
3sopGDPNeuronal-specific septin-3/0.441