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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1v0pPVBCell division control protein 2 homolog2.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1v0pPVBCell division control protein 2 homolog2.7.11.221.000
3s2pPMUCyclin-dependent kinase 22.7.11.220.541
2r64740Cyclin-dependent kinase 22.7.11.220.540
2wotZZGTGF-beta receptor type-12.7.11.300.522
2iw84SPCyclin-dependent kinase 22.7.11.220.517
4cfnJYMCyclin-dependent kinase 22.7.11.220.515
3lfqA28Cyclin-dependent kinase 22.7.11.220.511
1ckpPVBCyclin-dependent kinase 22.7.11.220.510
2uzlC94Cyclin-dependent kinase 22.7.11.220.510
1oirHDYCyclin-dependent kinase 22.7.11.220.509
2iw94SPCyclin-dependent kinase 22.7.11.220.506
2c6kDT2Cyclin-dependent kinase 22.7.11.220.505
2x1nX1NCyclin-dependent kinase 22.7.11.220.505
3ddpRC8Cyclin-dependent kinase 22.7.11.220.505
4eor4SPCyclin-dependent kinase 22.7.11.220.503
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.501
2duv371Cyclin-dependent kinase 22.7.11.220.500
2w05FRTCyclin-dependent kinase 22.7.11.220.500
3rni21ZCyclin-dependent kinase 22.7.11.220.500
2r3iSCFCyclin-dependent kinase 22.7.11.220.499
1unlRRCCyclin-dependent-like kinase 52.7.11.10.498
3r9dX6BCyclin-dependent kinase 22.7.11.220.496
4ek816KCyclin-dependent kinase 22.7.11.220.496
1g5sI17Cyclin-dependent kinase 22.7.11.220.495
2a0cCK9Cyclin-dependent kinase 22.7.11.220.495
1oguST8Cyclin-dependent kinase 22.7.11.220.493
1y91CT9Cyclin-dependent kinase 22.7.11.220.493
3rk507ZCyclin-dependent kinase 22.7.11.220.493
1h0w207Cyclin-dependent kinase 22.7.11.220.492
4bcpT3CCyclin-dependent kinase 22.7.11.220.492
3qrtX14Cyclin-dependent kinase 22.7.11.220.491
3qtzX42Cyclin-dependent kinase 22.7.11.220.491
2btsU32Cyclin-dependent kinase 22.7.11.220.490
1gih1PUCyclin-dependent kinase 22.7.11.220.489
2c6o4SPCyclin-dependent kinase 22.7.11.220.489
2vv9IM9Cyclin-dependent kinase 22.7.11.220.489
3r73X87Cyclin-dependent kinase 22.7.11.220.489
3qwkX62Cyclin-dependent kinase 22.7.11.220.487
3r1sX73Cyclin-dependent kinase 22.7.11.220.487
3r8vZ62Cyclin-dependent kinase 22.7.11.220.487
4fkpLS5Cyclin-dependent kinase 22.7.11.220.487
2r3r6SCCyclin-dependent kinase 22.7.11.220.486
4fks46KCyclin-dependent kinase 22.7.11.220.486
3r71X86Cyclin-dependent kinase 22.7.11.220.484
2c5nCK8Cyclin-dependent kinase 22.7.11.220.483
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.483
4bcoT6QCyclin-dependent kinase 22.7.11.220.483
1fvt106Cyclin-dependent kinase 22.7.11.220.481
1oitHDTCyclin-dependent kinase 22.7.11.220.481
2c6mDT5Cyclin-dependent kinase 22.7.11.220.481
1h1s4SPCyclin-dependent kinase 22.7.11.220.480
1h1q2A6Cyclin-dependent kinase 22.7.11.220.479
2a4lRRCCyclin-dependent kinase 22.7.11.220.479
2ds11CDCyclin-dependent kinase 22.7.11.220.479
2uzbC75Cyclin-dependent kinase 22.7.11.220.479
3r8pZ46Cyclin-dependent kinase 22.7.11.220.479
1b39ATPCyclin-dependent kinase 22.7.11.220.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.478
4fkr45KCyclin-dependent kinase 22.7.11.220.478
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.477
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.477
3rpv26ZCyclin-dependent kinase 22.7.11.220.476
3sqq99ZCyclin-dependent kinase 22.7.11.220.476
1ke7LS3Cyclin-dependent kinase 22.7.11.220.475
3le62BZCyclin-dependent kinase 22.7.11.220.475
3lfnA27Cyclin-dependent kinase 22.7.11.220.475
3qqlX03Cyclin-dependent kinase 22.7.11.220.475
3qxoX65Cyclin-dependent kinase 22.7.11.220.475
3r28XA0Cyclin-dependent kinase 22.7.11.220.475
4fkv61KCyclin-dependent kinase 22.7.11.220.475
1pxpCK8Cyclin-dependent kinase 22.7.11.220.474
3rmf20ZCyclin-dependent kinase 22.7.11.220.474
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.474
3mtfA3FActivin receptor type-12.7.11.300.473
3qu0X40Cyclin-dependent kinase 22.7.11.220.473
2b54D05Cyclin-dependent kinase 22.7.11.220.472
2r3gSC9Cyclin-dependent kinase 22.7.11.220.472
2uznC96Cyclin-dependent kinase 22.7.11.220.472
2w17I19Cyclin-dependent kinase 22.7.11.220.472
3s00Z60Cyclin-dependent kinase 22.7.11.220.472
3s0o50ZCyclin-dependent kinase 22.7.11.220.472
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
1h1r6CPCyclin-dependent kinase 22.7.11.220.470
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.470
3roy22ZCyclin-dependent kinase 22.7.11.220.470
2vu3LZECyclin-dependent kinase 22.7.11.220.469
3dogNNNCyclin-dependent kinase 22.7.11.220.469
4ez50RSCyclin-dependent kinase 62.7.11.220.469
1oi9N20Cyclin-dependent kinase 22.7.11.220.468
3qtuX44Cyclin-dependent kinase 22.7.11.220.468
3rk708ZCyclin-dependent kinase 22.7.11.220.468
3rpo24ZCyclin-dependent kinase 22.7.11.220.468
4bcmT7ZCyclin-dependent kinase 22.7.11.220.468
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.468
1w0xOLOCyclin-dependent kinase 22.7.11.220.467
4fko20KCyclin-dependent kinase 22.7.11.220.467
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.467
4fx360KCyclin-dependent kinase 22.7.11.220.467
4i22IREEpidermal growth factor receptor2.7.10.10.467
2w06FRVCyclin-dependent kinase 22.7.11.220.466
2y9qANPMitogen-activated protein kinase 12.7.11.240.466
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.466
1pxlCK4Cyclin-dependent kinase 22.7.11.220.465
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.465
1vyw292Cyclin-dependent kinase 22.7.11.220.465
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.465
2c6iDT1Cyclin-dependent kinase 22.7.11.220.465
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.465
3r7yZ04Cyclin-dependent kinase 22.7.11.220.465
4fuxE75Mitogen-activated protein kinase 12.7.11.240.465
4eok4SPCyclin-dependent kinase 22.7.11.220.464
1ke6LS2Cyclin-dependent kinase 22.7.11.220.463
3nynSGVG protein-coupled receptor kinase 62.7.11.160.463
3qzgX67Cyclin-dependent kinase 22.7.11.220.463
4bgh3I6Cyclin-dependent kinase 22.7.11.220.463
4fkt48KCyclin-dependent kinase 22.7.11.220.463
1dm2HMDCyclin-dependent kinase 22.7.11.220.462
1pxmCK5Cyclin-dependent kinase 22.7.11.220.462
2bheBRYCyclin-dependent kinase 22.7.11.220.462
3qqkX02Cyclin-dependent kinase 22.7.11.220.462
3r1qX75Cyclin-dependent kinase 22.7.11.220.462
3r6xX84Cyclin-dependent kinase 22.7.11.220.462
3r8lZ30Cyclin-dependent kinase 22.7.11.220.462
4acm7YGCyclin-dependent kinase 22.7.11.220.462
4b99R4LMitogen-activated protein kinase 72.7.11.240.462
4fkq42KCyclin-dependent kinase 22.7.11.220.462
4fkw62KCyclin-dependent kinase 22.7.11.220.462
4xgxADPFAD:protein FMN transferase/0.462
1urwI1PCyclin-dependent kinase 22.7.11.220.461
2bkzSBCCyclin-dependent kinase 22.7.11.220.461
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
1gij2PUCyclin-dependent kinase 22.7.11.220.460
2i40BLZCyclin-dependent kinase 22.7.11.220.460
2w1hL0FCyclin-dependent kinase 22.7.11.220.460
4eoi1ROCyclin-dependent kinase 22.7.11.220.460
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.460
1di8DTQCyclin-dependent kinase 22.7.11.220.459
3qx4X4BCyclin-dependent kinase 22.7.11.220.459
4fkg4CKCyclin-dependent kinase 22.7.11.220.459
2b52D42Cyclin-dependent kinase 22.7.11.220.458
2r3o2SCCyclin-dependent kinase 22.7.11.220.458
3py0SU9Cyclin-dependent kinase 22.7.11.220.458
1h0vUN4Cyclin-dependent kinase 22.7.11.220.457
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.457
2fvdLIACyclin-dependent kinase 22.7.11.220.457
3ezvEZVCyclin-dependent kinase 22.7.11.220.457
3qwjX6ACyclin-dependent kinase 22.7.11.220.457
3ral04ZCyclin-dependent kinase 22.7.11.220.457
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
1b38ATPCyclin-dependent kinase 22.7.11.220.456
2b53D23Cyclin-dependent kinase 22.7.11.220.456
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.456
2hog710Serine/threonine-protein kinase Chk12.7.11.10.456
3iggEFQCyclin-dependent kinase 22.7.11.220.456
3r7iX9ICyclin-dependent kinase 22.7.11.220.456
4eol1ROCyclin-dependent kinase 22.7.11.220.456
2j9mPY8Cyclin-dependent kinase 22.7.11.220.455
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.455
3lfsA07Cyclin-dependent kinase 22.7.11.220.455
3pj8404Cyclin-dependent kinase 22.7.11.220.455
1ke9LS5Cyclin-dependent kinase 22.7.11.220.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.454
1pxkCK3Cyclin-dependent kinase 22.7.11.220.454
1vyzN5BCyclin-dependent kinase 22.7.11.220.454
3rk909ZCyclin-dependent kinase 22.7.11.220.454
3w32W32Epidermal growth factor receptor2.7.10.10.454
1gii1PUCyclin-dependent kinase 22.7.11.220.453
2vtqLZACyclin-dependent kinase 22.7.11.220.453
2xmyCDKCyclin-dependent kinase 22.7.11.220.453
3nwq2NCGag-Pol polyprotein3.4.23.160.453
3rm719ZCyclin-dependent kinase 22.7.11.220.453
4ic7ANPMitogen-activated protein kinase 72.7.11.240.453
1oiqHDUCyclin-dependent kinase 22.7.11.220.452
1y8yCT7Cyclin-dependent kinase 22.7.11.220.452
2oji33AMitogen-activated protein kinase 12.7.11.240.452
2r3jSCJCyclin-dependent kinase 22.7.11.220.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
1fvv107Cyclin-dependent kinase 22.7.11.220.451
1jstATPCyclin-dependent kinase 22.7.11.220.451
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
3nup3NUCyclin-dependent kinase 62.7.11.220.451
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.451
4c4jX21Dual specificity protein kinase TTK2.7.12.10.451
4eon1ROCyclin-dependent kinase 22.7.11.220.451
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.451
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.450
2izsBRQCasein kinase I isoform gamma-32.7.11.10.450
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.450
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
1pxjCK2Cyclin-dependent kinase 22.7.11.220.449
3qziX72Cyclin-dependent kinase 22.7.11.220.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
4ib4ERM5-hydroxytryptamine receptor 2B/0.449
1e9hINRCyclin-dependent kinase 22.7.11.220.448
1xjdSTUProtein kinase C theta type2.7.11.130.448
2b55D31Cyclin-dependent kinase 22.7.11.220.448
2wihP48Cyclin-dependent kinase 22.7.11.220.448
3qruX19Cyclin-dependent kinase 22.7.11.220.448
3r7vZ02Cyclin-dependent kinase 22.7.11.220.448
3rm618ZCyclin-dependent kinase 22.7.11.220.448
3s1h56ZCyclin-dependent kinase 22.7.11.220.448
4eomATPCyclin-dependent kinase 22.7.11.220.448
1ir3ANPInsulin receptor2.7.10.10.447
1v1k3FPCyclin-dependent kinase 22.7.11.220.447
1ykr628Cyclin-dependent kinase 22.7.11.220.447
2c6tDT5Cyclin-dependent kinase 22.7.11.220.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
2uzeC95Cyclin-dependent kinase 22.7.11.220.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3qqfX07Cyclin-dependent kinase 22.7.11.220.447
3t8oATPRhodopsin kinase/0.447
3unj0BXCyclin-dependent kinase 22.7.11.220.447
4ek610KCyclin-dependent kinase 22.7.11.220.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
2dwbANPAurora kinase A2.7.11.10.446
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.446
3g70A5TRenin3.4.23.150.446
3r1yX76Cyclin-dependent kinase 22.7.11.220.446
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.446
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2r3lSCWCyclin-dependent kinase 22.7.11.220.445
3c50ADPRhodopsin kinase/0.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
4bcnT9NCyclin-dependent kinase 22.7.11.220.445
4yuqKS1Calmodulin-like domain protein kinase/0.445
1xddAAYIntegrin alpha-L/0.444
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.444
2c5yMTWCyclin-dependent kinase 22.7.11.220.444
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.444
2uzdC85Cyclin-dependent kinase 22.7.11.220.444
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.444
3bheBZNGag-Pol polyprotein3.4.23.160.444
3k5uPFQAurora kinase A2.7.11.10.444
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.444
4k8aK8AFocal adhesion kinase 12.7.10.20.444
4kiq1RAMitogen-activated protein kinase 14/0.444
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.443
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
2itqITQEpidermal growth factor receptor2.7.10.10.443
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
2wpa889Cyclin-dependent kinase 22.7.11.220.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3mqe416Prostaglandin G/H synthase 21.14.99.10.443
3qzhX69Cyclin-dependent kinase 22.7.11.220.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
3rpr25ZCyclin-dependent kinase 22.7.11.220.443
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4bcqTJFCyclin-dependent kinase 22.7.11.220.443
4l9i8PRRhodopsin kinase/0.443
3uzcT4EAdenosine receptor A2a/0.443
1oiuN76Cyclin-dependent kinase 22.7.11.220.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
3uli1N3Cyclin-dependent kinase 22.7.11.220.442
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.441
3tz3B36Acetyl-CoA carboxylase/0.441
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.441
4kb81QNCasein kinase I isoform delta2.7.11.10.441
3qakUKAAdenosine receptor A2a/0.441
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.440
1v0oINRCell division control protein 2 homolog2.7.11.220.440
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.440
3nux3NVCyclin-dependent kinase 62.7.11.220.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
3raiX85Cyclin-dependent kinase 22.7.11.220.440
3sw719KCyclin-dependent kinase 22.7.11.220.440
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.440