sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.730 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.706 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.702 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.696 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.692 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.687 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.685 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.682 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.678 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.619 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.614 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.572 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.571 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.548 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.548 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.534 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.521 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.521 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.519 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.517 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.514 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.511 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.511 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.509 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.508 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.506 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.504 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.499 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.499 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.498 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.498 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.495 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.492 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.492 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.491 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.490 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.489 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.489 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.487 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.486 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.486 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.486 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.484 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.482 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.481 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.477 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.475 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.474 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.472 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.471 | |
| 1fml | RTL | Retinol dehydratase | / | 0.468 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.468 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.467 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.465 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.465 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.465 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.465 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.465 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.464 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.463 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.462 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.461 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.460 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.460 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.460 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.458 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.458 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.457 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.456 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.456 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.456 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4egn | TWO | Cytochrome P450 | / | 0.455 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.454 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.453 | |
| 3wec | AUI | Cytochrome P450 | / | 0.453 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.453 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 5a3b | APR | SIR2 family protein | / | 0.452 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4jic | FMN | GTN Reductase | / | 0.451 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.450 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2y3s | TIR | TamL | / | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.448 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.448 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.447 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.447 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.445 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.444 | |
| 2f1k | NAP | Prephenate dehydrogenase | / | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.443 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.441 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.441 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.440 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.440 | |
| 4l9q | 9TP | Serum albumin | / | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 |