sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 1.000 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.562 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.558 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.549 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.547 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.542 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.533 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.532 | |
| 4ksp | 1SU | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.530 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.526 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.526 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.518 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.505 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.504 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.504 | |
| 3p9t | TCL | Repressor | / | 0.504 | |
| 3hv5 | R24 | Mitogen-activated protein kinase 14 | / | 0.500 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.499 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.497 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.496 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.493 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.492 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.490 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.487 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.483 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.482 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.482 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.481 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.481 | |
| 1syn | F89 | Thymidylate synthase | / | 0.480 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.480 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.480 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.479 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.478 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.474 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.474 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.474 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.474 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.474 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.474 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.473 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.472 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.472 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.472 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.472 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.472 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.471 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.470 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.469 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.468 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.467 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.467 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.466 | |
| 2osc | MUH | Angiopoietin-1 receptor | 2.7.10.1 | 0.466 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.466 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.465 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.464 | |
| 1uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.464 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.464 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.464 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 2ejz | SAH | Diphthine synthase | / | 0.463 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.463 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.463 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.463 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.463 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.462 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.462 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.461 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.461 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.461 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.461 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.461 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.461 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.460 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.460 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 3up0 | D7S | aceDAF-12 | / | 0.459 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.459 | |
| 5dp2 | NAP | CurF | / | 0.459 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.458 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.458 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2yhu | WHF | Pteridine reductase | / | 0.458 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.458 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.458 | |
| 4lb2 | DM5 | Serum albumin | / | 0.458 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.458 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.457 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.457 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.457 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.457 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.457 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 2c9e | PID | Peridinin-chlorophyll a protein, high-salt form | / | 0.456 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.456 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.456 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.456 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.455 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.455 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.455 | |
| 3hy4 | N5G | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.455 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.455 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.455 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.454 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3of1 | CMP | cAMP-dependent protein kinase regulatory subunit | / | 0.454 | |
| 3up3 | XCA | aceDAF-12 | / | 0.454 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.454 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.453 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.453 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.453 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.452 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.452 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.452 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.451 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.451 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.451 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 5bn4 | ANP | V-type ATP synthase alpha chain | / | 0.451 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.450 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.450 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.449 | |
| 2jbl | SMA | Reaction center protein L chain | / | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.449 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.449 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.449 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.449 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.449 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.448 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.448 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 1zdw | FLV | Prenyltransferase | / | 0.448 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.448 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.448 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.448 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.448 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.448 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.448 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.447 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.447 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.447 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.446 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.446 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.446 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.446 | |
| 4la0 | 198 | Serum albumin | / | 0.446 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.446 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.446 | |
| 1c7o | PPG | Hemolysin | / | 0.445 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.445 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.445 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.445 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.445 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.445 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.445 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.445 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.445 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.445 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.444 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.444 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 2xno | ED8 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.444 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.443 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2vcg | S17 | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.443 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.443 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.443 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.443 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.443 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1typ | NAP | Trypanothione reductase | 1.8.1.12 | 0.442 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.442 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.442 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.442 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.442 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.442 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.441 | |
| 1gaw | FAD | Ferredoxin | / | 0.441 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.441 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.441 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.441 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.441 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.441 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.441 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.441 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.441 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.440 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.440 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.440 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.440 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.440 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.440 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.440 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.440 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.440 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.440 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.440 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.440 |