sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1us0 | LDT | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.829 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.791 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.770 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.762 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.762 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.741 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.738 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.735 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.729 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.725 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.718 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.712 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.708 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.687 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.676 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.670 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.666 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.663 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.661 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.656 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.652 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.651 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.649 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.643 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.639 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.636 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.633 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.617 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.616 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.614 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.610 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.602 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.590 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.586 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.582 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.577 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.573 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.569 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.569 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.567 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.566 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.563 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.559 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.552 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.538 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.509 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.507 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.507 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.505 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.504 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.504 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.501 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.500 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.497 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.496 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.496 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.495 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.495 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.494 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.494 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.494 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.494 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.490 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.490 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.489 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.489 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.487 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.487 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.483 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 1rxj | BNI | Streptavidin | / | 0.482 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.482 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.481 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.481 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.481 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.481 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.480 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.480 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.479 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.479 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.478 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.477 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.477 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.477 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.476 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.476 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.474 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.473 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.473 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.473 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.473 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.472 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.472 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.471 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.471 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.471 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.471 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.470 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 4xwt | U5P | Ribonuclease J | / | 0.470 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.469 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.469 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.469 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.469 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.468 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.468 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.468 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.468 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.467 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.467 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.467 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.467 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.466 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.466 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.465 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.465 | |
| 4mm9 | FVX | Na(+):neurotransmitter symporter (Snf family) | / | 0.465 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.465 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.465 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.464 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.464 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.464 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.464 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.464 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.464 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.463 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.463 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.462 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.462 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.462 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.462 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.462 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.461 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.461 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.461 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.461 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.460 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.460 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.460 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.460 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.460 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.459 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.459 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.459 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.459 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.459 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.458 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.458 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.458 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.458 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.458 | |
| 1jf0 | CZH | Obelin | / | 0.457 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4kmz | FOL | Folate receptor beta | / | 0.457 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.457 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.456 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.456 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.456 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2hzq | STR | Apolipoprotein D | / | 0.456 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.456 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4hcy | 0YN | Transketolase | / | 0.456 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.456 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.456 | |
| 4mm4 | 8PR | Na(+):neurotransmitter symporter (Snf family) | / | 0.456 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.456 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.455 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.455 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.455 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.455 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.455 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.455 | |
| 1c7o | PPG | Hemolysin | / | 0.454 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.454 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.454 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.454 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.454 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.453 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.453 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.453 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.452 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.452 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.452 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.452 | |
| 4kxj | P34 | Nucleoprotein | / | 0.452 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.452 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.452 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.451 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.451 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.450 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1qv0 | CZH | Obelin | / | 0.450 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.450 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3pn1 | IVH | DNA ligase | / | 0.448 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.447 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.447 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.447 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.447 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.447 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1lke | DOG | Bilin-binding protein | / | 0.446 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.446 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.446 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.446 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.446 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.446 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.446 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.445 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.445 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.445 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.445 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.445 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.445 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.444 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.444 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.444 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 1jf2 | CZH | Obelin | / | 0.443 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.443 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.443 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.443 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4nv7 | COA | Arylamine N-acetyltransferase | / | 0.443 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.442 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.442 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.442 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.442 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3jta | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3keg | MRE | FMN-dependent NADH-azoreductase 1 | / | 0.442 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.442 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.442 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4fj0 | HHF | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.441 | |
| 4tny | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3htj | ET | EbrA repressor | / | 0.440 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.440 | |
| 3qvi | K95 | HAP protein | / | 0.440 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.440 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.440 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.440 |