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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1urwI1PCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1urwI1PCyclin-dependent kinase 22.7.11.221.000
3qtzX42Cyclin-dependent kinase 22.7.11.220.616
3rak03ZCyclin-dependent kinase 22.7.11.220.611
3s1h56ZCyclin-dependent kinase 22.7.11.220.608
3r9dX6BCyclin-dependent kinase 22.7.11.220.607
3rpv26ZCyclin-dependent kinase 22.7.11.220.602
1v1k3FPCyclin-dependent kinase 22.7.11.220.600
3rmf20ZCyclin-dependent kinase 22.7.11.220.595
3ral04ZCyclin-dependent kinase 22.7.11.220.593
4acm7YGCyclin-dependent kinase 22.7.11.220.592
1ke6LS2Cyclin-dependent kinase 22.7.11.220.590
4bgh3I6Cyclin-dependent kinase 22.7.11.220.590
1di8DTQCyclin-dependent kinase 22.7.11.220.589
1oiqHDUCyclin-dependent kinase 22.7.11.220.589
3rni21ZCyclin-dependent kinase 22.7.11.220.587
2b55D31Cyclin-dependent kinase 22.7.11.220.586
3rjc06ZCyclin-dependent kinase 22.7.11.220.586
1pxmCK5Cyclin-dependent kinase 22.7.11.220.581
2w06FRVCyclin-dependent kinase 22.7.11.220.581
3unj0BXCyclin-dependent kinase 22.7.11.220.581
3ezvEZVCyclin-dependent kinase 22.7.11.220.579
4fkr45KCyclin-dependent kinase 22.7.11.220.579
2a0cCK9Cyclin-dependent kinase 22.7.11.220.578
3qtuX44Cyclin-dependent kinase 22.7.11.220.576
3unk0BYCyclin-dependent kinase 22.7.11.220.576
4fko20KCyclin-dependent kinase 22.7.11.220.576
1oitHDTCyclin-dependent kinase 22.7.11.220.575
3qtrX36Cyclin-dependent kinase 22.7.11.220.575
3qu0X40Cyclin-dependent kinase 22.7.11.220.575
3sw418KCyclin-dependent kinase 22.7.11.220.574
3sw719KCyclin-dependent kinase 22.7.11.220.574
3r9oZ71Cyclin-dependent kinase 22.7.11.220.570
1ke5LS1Cyclin-dependent kinase 22.7.11.220.569
3qxpX64Cyclin-dependent kinase 22.7.11.220.569
3lfnA27Cyclin-dependent kinase 22.7.11.220.568
1oi9N20Cyclin-dependent kinase 22.7.11.220.565
3sqq99ZCyclin-dependent kinase 22.7.11.220.559
3rk708ZCyclin-dependent kinase 22.7.11.220.557
1g5sI17Cyclin-dependent kinase 22.7.11.220.556
2w05FRTCyclin-dependent kinase 22.7.11.220.556
3r9hZ67Cyclin-dependent kinase 22.7.11.220.556
1gih1PUCyclin-dependent kinase 22.7.11.220.555
1oiyN41Cyclin-dependent kinase 22.7.11.220.555
3qtxX43Cyclin-dependent kinase 22.7.11.220.554
3s0o50ZCyclin-dependent kinase 22.7.11.220.553
2vv9IM9Cyclin-dependent kinase 22.7.11.220.551
3r1sX73Cyclin-dependent kinase 22.7.11.220.551
3qxoX65Cyclin-dependent kinase 22.7.11.220.550
4erwSTUCyclin-dependent kinase 22.7.11.220.550
1h1r6CPCyclin-dependent kinase 22.7.11.220.549
1gii1PUCyclin-dependent kinase 22.7.11.220.548
1w0xOLOCyclin-dependent kinase 22.7.11.220.548
2xmyCDKCyclin-dependent kinase 22.7.11.220.548
2c6iDT1Cyclin-dependent kinase 22.7.11.220.546
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.546
3rk909ZCyclin-dependent kinase 22.7.11.220.546
3uli1N3Cyclin-dependent kinase 22.7.11.220.546
1gij2PUCyclin-dependent kinase 22.7.11.220.544
3ti1B49Cyclin-dependent kinase 22.7.11.220.544
4fkq42KCyclin-dependent kinase 22.7.11.220.544
4fkv61KCyclin-dependent kinase 22.7.11.220.544
2fvdLIACyclin-dependent kinase 22.7.11.220.543
2iw84SPCyclin-dependent kinase 22.7.11.220.543
2r3lSCWCyclin-dependent kinase 22.7.11.220.543
3rkb12ZCyclin-dependent kinase 22.7.11.220.543
3s2pPMUCyclin-dependent kinase 22.7.11.220.540
3qzgX67Cyclin-dependent kinase 22.7.11.220.539
3rm719ZCyclin-dependent kinase 22.7.11.220.538
4eok4SPCyclin-dependent kinase 22.7.11.220.538
1ke7LS3Cyclin-dependent kinase 22.7.11.220.536
3py0SU9Cyclin-dependent kinase 22.7.11.220.534
1oguST8Cyclin-dependent kinase 22.7.11.220.533
2btsU32Cyclin-dependent kinase 22.7.11.220.533
3roy22ZCyclin-dependent kinase 22.7.11.220.533
2c6o4SPCyclin-dependent kinase 22.7.11.220.532
1h1s4SPCyclin-dependent kinase 22.7.11.220.531
3ddpRC8Cyclin-dependent kinase 22.7.11.220.531
1aq1STUCyclin-dependent kinase 22.7.11.220.530
3qzhX69Cyclin-dependent kinase 22.7.11.220.530
3rpy27ZCyclin-dependent kinase 22.7.11.220.530
1ke9LS5Cyclin-dependent kinase 22.7.11.220.529
4ek816KCyclin-dependent kinase 22.7.11.220.529
2b52D42Cyclin-dependent kinase 22.7.11.220.527
3ezrEZRCyclin-dependent kinase 22.7.11.220.527
3qqkX02Cyclin-dependent kinase 22.7.11.220.527
3rk507ZCyclin-dependent kinase 22.7.11.220.526
2iw94SPCyclin-dependent kinase 22.7.11.220.525
4fkw62KCyclin-dependent kinase 22.7.11.220.525
4fx360KCyclin-dependent kinase 22.7.11.220.525
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.524
3r6xX84Cyclin-dependent kinase 22.7.11.220.523
3r8lZ30Cyclin-dependent kinase 22.7.11.220.523
1p2a5BNCyclin-dependent kinase 22.7.11.220.522
3qqfX07Cyclin-dependent kinase 22.7.11.220.522
1pkdUCNCyclin-dependent kinase 22.7.11.220.521
3r71X86Cyclin-dependent kinase 22.7.11.220.521
2j9mPY8Cyclin-dependent kinase 22.7.11.220.520
3rpo24ZCyclin-dependent kinase 22.7.11.220.520
3iggEFQCyclin-dependent kinase 22.7.11.220.519
1ykr628Cyclin-dependent kinase 22.7.11.220.518
2vttLZDCyclin-dependent kinase 22.7.11.220.518
3pj8404Cyclin-dependent kinase 22.7.11.220.518
3r8vZ62Cyclin-dependent kinase 22.7.11.220.518
1r78FMDCyclin-dependent kinase 22.7.11.220.517
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.517
1e9hINRCyclin-dependent kinase 22.7.11.220.516
3qruX19Cyclin-dependent kinase 22.7.11.220.516
4fks46KCyclin-dependent kinase 22.7.11.220.516
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.516
2r64740Cyclin-dependent kinase 22.7.11.220.515
2w17I19Cyclin-dependent kinase 22.7.11.220.515
4bcmT7ZCyclin-dependent kinase 22.7.11.220.515
1y91CT9Cyclin-dependent kinase 22.7.11.220.513
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.513
2r3iSCFCyclin-dependent kinase 22.7.11.220.512
3r73X87Cyclin-dependent kinase 22.7.11.220.511
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.511
1oirHDYCyclin-dependent kinase 22.7.11.220.510
3r8zZ63Cyclin-dependent kinase 22.7.11.220.510
4qmpDKISerine/threonine-protein kinase 242.7.11.10.510
4ek610KCyclin-dependent kinase 22.7.11.220.509
4ez30S0Cyclin-dependent kinase 22.7.11.220.509
4fkt48KCyclin-dependent kinase 22.7.11.220.509
1pyePM1Cyclin-dependent kinase 22.7.11.220.507
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.507
2bheBRYCyclin-dependent kinase 22.7.11.220.506
3ddqRRCCyclin-dependent kinase 22.7.11.220.505
3qwkX62Cyclin-dependent kinase 22.7.11.220.505
4fkpLS5Cyclin-dependent kinase 22.7.11.220.505
1vyzN5BCyclin-dependent kinase 22.7.11.220.503
3pxyJWSCyclin-dependent kinase 22.7.11.220.503
3r7vZ02Cyclin-dependent kinase 22.7.11.220.503
2r3p3SCCyclin-dependent kinase 22.7.11.220.502
2btrU73Cyclin-dependent kinase 22.7.11.220.500
2vtqLZACyclin-dependent kinase 22.7.11.220.499
2vtsLZCCyclin-dependent kinase 22.7.11.220.499
3qqlX03Cyclin-dependent kinase 22.7.11.220.499
3r83Z14Cyclin-dependent kinase 22.7.11.220.499
4fki09KCyclin-dependent kinase 22.7.11.220.499
1fvv107Cyclin-dependent kinase 22.7.11.220.498
2r3kSCQCyclin-dependent kinase 22.7.11.220.498
1pxoCK7Cyclin-dependent kinase 22.7.11.220.497
2i40BLZCyclin-dependent kinase 22.7.11.220.497
3ig7EFPCyclin-dependent kinase 22.7.11.220.497
3r7yZ04Cyclin-dependent kinase 22.7.11.220.496
4eor4SPCyclin-dependent kinase 22.7.11.220.496
2duv371Cyclin-dependent kinase 22.7.11.220.494
3r1qX75Cyclin-dependent kinase 22.7.11.220.494
3r7uX96Cyclin-dependent kinase 22.7.11.220.494
4bcpT3CCyclin-dependent kinase 22.7.11.220.494
1h1pCMGCyclin-dependent kinase 22.7.11.220.493
2uznC96Cyclin-dependent kinase 22.7.11.220.493
3r28XA0Cyclin-dependent kinase 22.7.11.220.493
3qwjX6ACyclin-dependent kinase 22.7.11.220.492
1ckpPVBCyclin-dependent kinase 22.7.11.220.491
2vu3LZECyclin-dependent kinase 22.7.11.220.491
3qqhX0ACyclin-dependent kinase 22.7.11.220.490
3rm618ZCyclin-dependent kinase 22.7.11.220.490
3r1yX76Cyclin-dependent kinase 22.7.11.220.489
3tnwF18Cyclin-dependent kinase 22.7.11.220.489
1fvt106Cyclin-dependent kinase 22.7.11.220.488
1ke8LS4Cyclin-dependent kinase 22.7.11.220.488
3lfqA28Cyclin-dependent kinase 22.7.11.220.488
3r8uZ31Cyclin-dependent kinase 22.7.11.220.488
1pxlCK4Cyclin-dependent kinase 22.7.11.220.487
2w1hL0FCyclin-dependent kinase 22.7.11.220.487
1oiuN76Cyclin-dependent kinase 22.7.11.220.486
3r7iX9ICyclin-dependent kinase 22.7.11.220.486
3wblPDYCyclin-dependent kinase 22.7.11.220.486
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.486
3qtqX35Cyclin-dependent kinase 22.7.11.220.485
3qx2X63Cyclin-dependent kinase 22.7.11.220.483
2c69CT8Cyclin-dependent kinase 22.7.11.220.482
4kd11QKCyclin-dependent kinase 22.7.11.220.482
1pxkCK3Cyclin-dependent kinase 22.7.11.220.481
1w8cN69Cyclin-dependent kinase 22.7.11.220.481
3le62BZCyclin-dependent kinase 22.7.11.220.481
4bcnT9NCyclin-dependent kinase 22.7.11.220.480
4lyn1YGCyclin-dependent kinase 22.7.11.220.480
2r3jSCJCyclin-dependent kinase 22.7.11.220.479
2r3mSCXCyclin-dependent kinase 22.7.11.220.479
3dogNNNCyclin-dependent kinase 22.7.11.220.479
4eoi1ROCyclin-dependent kinase 22.7.11.220.479
1pxpCK8Cyclin-dependent kinase 22.7.11.220.478
2a4lRRCCyclin-dependent kinase 22.7.11.220.478
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.478
3qrtX14Cyclin-dependent kinase 22.7.11.220.478
2pvnP63Casein kinase II subunit alpha2.7.11.10.477
3r7eX88Cyclin-dependent kinase 22.7.11.220.477
3rzb02ZCyclin-dependent kinase 22.7.11.220.477
1h0w207Cyclin-dependent kinase 22.7.11.220.476
1vyw292Cyclin-dependent kinase 22.7.11.220.476
3at4CCKCasein kinase II subunit alpha2.7.11.10.476
2eufLQQCyclin-dependent kinase 62.7.11.220.475
2xnbY8LCyclin-dependent kinase 22.7.11.220.475
4bcoT6QCyclin-dependent kinase 22.7.11.220.475
3tiz3TICyclin-dependent kinase 22.7.11.220.474
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.474
2c6tDT5Cyclin-dependent kinase 22.7.11.220.473
3lfsA07Cyclin-dependent kinase 22.7.11.220.473
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.472
2c5nCK8Cyclin-dependent kinase 22.7.11.220.471
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.471
4eon1ROCyclin-dependent kinase 22.7.11.220.471
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.470
3qtwX3ACyclin-dependent kinase 22.7.11.220.470
4ez50RSCyclin-dependent kinase 62.7.11.220.470
2c6kDT2Cyclin-dependent kinase 22.7.11.220.469
2r3gSC9Cyclin-dependent kinase 22.7.11.220.468
1unlRRCCyclin-dependent-like kinase 52.7.11.10.467
2bhhRYUCyclin-dependent kinase 22.7.11.220.467
4eol1ROCyclin-dependent kinase 22.7.11.220.467
3r8pZ46Cyclin-dependent kinase 22.7.11.220.466
4fkj11KCyclin-dependent kinase 22.7.11.220.466
2x1nX1NCyclin-dependent kinase 22.7.11.220.465
3qziX72Cyclin-dependent kinase 22.7.11.220.463
4bcqTJFCyclin-dependent kinase 22.7.11.220.463
3ql8X01Cyclin-dependent kinase 22.7.11.220.462
3be9P04Casein kinase II subunit alpha2.7.11.10.461
4eomATPCyclin-dependent kinase 22.7.11.220.461
2wihP48Cyclin-dependent kinase 22.7.11.220.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
2uzdC85Cyclin-dependent kinase 22.7.11.220.459
4fkg4CKCyclin-dependent kinase 22.7.11.220.459
1e1xNW1Cyclin-dependent kinase 22.7.11.220.458
3raiX85Cyclin-dependent kinase 22.7.11.220.458
2vthLZ2Cyclin-dependent kinase 22.7.11.220.457
3my5RFZCyclin-dependent kinase 22.7.11.220.457
4eos1ROCyclin-dependent kinase 22.7.11.220.457
2c4g514Cyclin-dependent kinase 22.7.11.220.456
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.456
3nux3NVCyclin-dependent kinase 62.7.11.220.456
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.456
2r3o2SCCyclin-dependent kinase 22.7.11.220.455
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.455
2c6lDT4Cyclin-dependent kinase 22.7.11.220.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3nga3NGCasein kinase II subunit alpha2.7.11.10.454
3r9nZ68Cyclin-dependent kinase 22.7.11.220.454
4cfnJYMCyclin-dependent kinase 22.7.11.220.454
1xjdSTUProtein kinase C theta type2.7.11.130.453
2uzeC95Cyclin-dependent kinase 22.7.11.220.453
2wpa889Cyclin-dependent kinase 22.7.11.220.453
3lq5SLQCyclin-dependent kinase 92.7.11.220.452
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.452
2r3r6SCCyclin-dependent kinase 22.7.11.220.450
3fz1B98Cyclin-dependent kinase 22.7.11.220.450
4fklCK2Cyclin-dependent kinase 22.7.11.220.450
2cchATPCyclin-dependent kinase 22.7.11.220.449
2wotZZGTGF-beta receptor type-12.7.11.300.449
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4bchT7ZCyclin-dependent kinase 92.7.11.220.448
4eop1ROCyclin-dependent kinase 22.7.11.220.448
1dm2HMDCyclin-dependent kinase 22.7.11.220.447
1v0pPVBCell division control protein 2 homolog2.7.11.220.447
2f2cAP9Cyclin-dependent kinase 62.7.11.220.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
2r3fSC8Cyclin-dependent kinase 22.7.11.220.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
3at3ATKCasein kinase II subunit alpha2.7.11.10.447
4anmWULCasein kinase II subunit alpha2.7.11.10.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.446
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.446
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.445
3wowANPCasein kinase II subunit alpha2.7.11.10.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
2c5yMTWCyclin-dependent kinase 22.7.11.220.444
4ogrADNCyclin-dependent kinase 92.7.11.220.444
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.444
1h1q2A6Cyclin-dependent kinase 22.7.11.220.443
2r3q5SCCyclin-dependent kinase 22.7.11.220.443
3rahO1ZCyclin-dependent kinase 22.7.11.220.443
2b54D05Cyclin-dependent kinase 22.7.11.220.442
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.442
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4c61LMMTyrosine-protein kinase JAK2/0.442
1finATPCyclin-dependent kinase 22.7.11.220.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3qzfX66Cyclin-dependent kinase 22.7.11.220.440
3sheI85MAP kinase-activated protein kinase 32.7.11.10.440
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.440
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.440