scPDB - Distribution of Binding site Similarity values of 1u72 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1u72	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1u72	MTX	Dihydrofolate reductase	1.5.1.3	1.000
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.623
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.612
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.605
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.603
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.596
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.595
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.582
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.560
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.554
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.552
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.549
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.549
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.549
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.540
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.534
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.529
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.525
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.519
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.507
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.507
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.505
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.498
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.497
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.497
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.497
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.494
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.493
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.493
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.475
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.471
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.469
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.468
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.466
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.465
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.464
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.462
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.454
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.453
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.451
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.445
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.440