scPDB - Distribution of Binding site Similarity values of 1u70 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1u70	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1u70	MTX	Dihydrofolate reductase	1.5.1.3	1.000
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.663
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.627
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.609
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.605
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.585
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.573
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.562
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.557
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.550
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.550
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.548
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.541
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.541
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.540
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.538
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.537
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.522
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.520
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.519
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.515
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.515
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.514
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.513
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.506
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.500
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.497
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.496
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.488
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.487
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.482
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.474
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.473
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.471
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.471
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.468
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.467
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.467
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.466
3qly	55V	Uncharacterized protein	/	0.464
3wav	DWV	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	3.1.4.39	0.458
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.456
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.456
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.453
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.451
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.449
3cse	N22	Uncharacterized protein	/	0.449
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.449
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.447
4c1i	EH9	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.447
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.445
3c72	CX1	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.445
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.444
3v94	WYQ	Phosphodiesterase	/	0.444
1y2c	3DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.443
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.443
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.443
3a1l	2CC	Cytochrome P450	/	0.442
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.441
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440