sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 1.000 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.489 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.488 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.485 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.483 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.483 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.482 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.480 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.477 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.476 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.475 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.473 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.469 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.469 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.468 | |
| 5ans | RX8 | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.468 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.467 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.466 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.466 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.465 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.465 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.464 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4boe | CLR | Japanin | / | 0.464 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.464 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.463 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2i8c | ADP | D-alanine--D-alanine ligase | / | 0.462 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.462 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.461 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.461 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3mes | PT3 | Putative choline kinase | / | 0.461 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.461 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.460 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.460 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.460 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.459 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.458 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.458 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.458 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.457 | |
| 1rxj | BNI | Streptavidin | / | 0.457 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.456 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.455 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 4zs4 | ATP | Myosin heavy chain kinase A | 2.7.11.7 | 0.455 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.455 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.454 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3oll | EST | Estrogen receptor beta | / | 0.454 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1rt2 | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.453 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.453 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.453 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.452 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.452 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 1lke | DOG | Bilin-binding protein | / | 0.450 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2pkl | DHT | Androgen receptor | / | 0.450 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.450 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.450 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.449 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 1syn | F89 | Thymidylate synthase | / | 0.449 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.449 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.449 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.449 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.449 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.449 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.448 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.448 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.447 | |
| 3rs0 | GNP | GTPase HRas | / | 0.447 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.446 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.446 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.446 | |
| 4hcy | 0YN | Transketolase | / | 0.446 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.445 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.445 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2b1z | 17M | Estrogen receptor | / | 0.445 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.445 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.445 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 3hy4 | N5G | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.445 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 4au7 | SAH | Histone-lysine N-methyltransferase KMT5C | 2.1.1.43 | 0.445 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.444 | |
| 1tkt | H12 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.444 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.444 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.444 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.444 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.444 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.444 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2piv | DHT | Androgen receptor | / | 0.443 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.443 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.443 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.443 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.442 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.442 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.442 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.441 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.441 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.441 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.441 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 4jhi | EMU | Nodulin-13 | / | 0.441 | |
| 4lb2 | DM5 | Serum albumin | / | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.440 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.440 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.440 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.440 |