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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1u2rSO1Elongation factor 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1u2rSO1Elongation factor 2/1.000
2npfMOUElongation factor 2/0.586
1n0uSO1Elongation factor 2/0.549
5jscFADPutative acyl-CoA dehydrogenase/0.461
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4a83DXCMajor pollen allergen Bet v 1-A/0.453
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.451
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.450
3l6jZ90Alr2278 protein/0.449
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4egbNADdTDP-glucose 4,6-dehydratase/0.444
3p4tFAOPutative acyl-CoA dehydrogenase/0.443
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441