Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
1txr | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
1txr | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 1.000 | |
1xry | BES | Bacterial leucyl aminopeptidase | 3.4.11.10 | 0.735 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.516 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.502 | |
4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.494 | |
3jpu | TY4 | Transcriptional activator protein LasR | / | 0.492 | |
4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.490 | |
4kov | KOV | Uncharacterized protein | / | 0.489 | |
1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.486 | |
3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.486 | |
1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.483 | |
3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.480 | |
3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.479 | |
3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
2zhf | 49U | Prothrombin | 3.4.21.5 | 0.476 | |
4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.476 | |
4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
4zu4 | 4TG | WxcM-like protein | / | 0.476 | |
3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.474 | |
2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.473 | |
2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.473 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.470 | |
3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.469 | |
1jwt | BLI | Prothrombin | 3.4.21.5 | 0.468 | |
3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
3e8x | NAP | BH1520 protein | / | 0.468 | |
4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.467 | |
1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.466 | |
3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
1uxk | NAD | Malate dehydrogenase | / | 0.465 | |
3bgx | TMP | Thymidylate synthase | / | 0.465 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.465 | |
2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.464 | |
3hdy | GDU | UDP-galactopyranose mutase | / | 0.464 | |
1kqw | RTL | Cellular retinol-binding protein type II | / | 0.463 | |
3oqk | S52 | Renin | 3.4.23.15 | 0.463 | |
1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.462 | |
3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.461 | |
2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 0.461 | |
2v13 | C40 | Renin | 3.4.23.15 | 0.461 | |
1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.460 | |
1nmk | SFM | Peptidyl-prolyl cis-trans isomerase A | 5.2.1.8 | 0.460 | |
1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.460 | |
2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.460 | |
3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
4an4 | DUD | Putative glycosyl transferase | / | 0.460 | |
4h9t | HL4 | Phosphotriesterase | / | 0.460 | |
1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.458 | |
2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
2zda | 32U | Prothrombin | 3.4.21.5 | 0.458 | |
3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.458 | |
4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
1kh3 | ANP | Argininosuccinate synthase | / | 0.457 | |
1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.457 | |
2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
2g24 | 7IG | Renin | 3.4.23.15 | 0.457 | |
2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.457 | |
2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.457 | |
2pb6 | SAH | Diphthine synthase | / | 0.457 | |
2zdv | 37U | Prothrombin | 3.4.21.5 | 0.457 | |
2zfq | 45U | Prothrombin | 3.4.21.5 | 0.457 | |
3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.456 | |
2oz5 | 7XY | Uncharacterized protein | / | 0.456 | |
4a6r | TA8 | Probable aminotransferase | / | 0.456 | |
4lzw | THM | Uridine phosphorylase | / | 0.456 | |
1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.455 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
3atz | FMN | Prostaglandin F2a synthase | / | 0.455 | |
3f63 | GTX | Glutathione transferase GST1-4 | / | 0.455 | |
3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.455 | |
3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.455 | |
4kot | CE3 | Uncharacterized protein | / | 0.455 | |
4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.455 | |
5dhh | DGW | Nociceptin receptor | / | 0.455 | |
1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.454 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
1ypk | CCR | Prothrombin | 3.4.21.5 | 0.454 | |
2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.454 | |
2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.454 | |
2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.454 | |
3pqb | VGP | Putative oxidoreductase | / | 0.454 | |
3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.454 | |
4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.454 | |
1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.453 | |
2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.453 | |
3c1o | NAP | Eugenol synthase | / | 0.453 | |
3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.453 | |
4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.453 | |
4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.453 | |
4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.453 | |
5c1m | CLR | Mu-type opioid receptor | / | 0.453 | |
1gsf | EAA | Glutathione S-transferase A1 | 2.5.1.18 | 0.452 | |
1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.452 | |
1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.452 | |
2i4q | UA4 | Renin | 3.4.23.15 | 0.452 | |
2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.452 | |
3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.452 | |
4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.452 | |
2g20 | L1A | Renin | 3.4.23.15 | 0.451 | |
2gvd | FKP | Adenylate cyclase type 2 | / | 0.451 | |
2gvd | FKP | Adenylate cyclase type 5 | / | 0.451 | |
2v16 | C47 | Renin | 3.4.23.15 | 0.451 | |
3b1d | PLS | BetaC-S lyase | / | 0.451 | |
3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.451 | |
4ffr | ATP | Uncharacterized protein | / | 0.451 | |
4zwg | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.450 | |
2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.450 | |
3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
3p9t | TCL | Repressor | / | 0.450 | |
2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.449 | |
2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
2gqp | PA7 | Endoplasmin | / | 0.449 | |
2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
2psw | COA | N-alpha-acetyltransferase 50 | / | 0.449 | |
3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.449 | |
3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.449 | |
4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
2emu | SAH | Diphthine synthase | / | 0.448 | |
2g1o | 2IG | Renin | 3.4.23.15 | 0.448 | |
3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.448 | |
3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.448 | |
3w3l | RX8 | Toll-like receptor 8 | / | 0.448 | |
3wle | NAD | (R)-specific carbonyl reductase | / | 0.448 | |
4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.448 | |
5c1g | GDU | Histo-blood group ABO system transferase | / | 0.448 | |
1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.447 | |
1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.447 | |
1txt | CAA | HMG-CoA synthase | / | 0.447 | |
1xrp | PRO_LEU_GLY_GLY | Proline iminopeptidase | 3.4.11.5 | 0.447 | |
2r2m | I50 | Prothrombin | 3.4.21.5 | 0.447 | |
4psb | GA3 | Cytokinin-specific binding protein | / | 0.447 | |
1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.446 | |
1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.446 | |
1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.446 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.446 | |
2emr | SAH | Diphthine synthase | / | 0.446 | |
2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.446 | |
2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
3ae4 | N1M | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.446 | |
3ae4 | N1M | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.446 | |
1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
2uuk | 897 | Prothrombin | 3.4.21.5 | 0.445 | |
2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.445 | |
2zhe | 13U | Prothrombin | 3.4.21.5 | 0.445 | |
3c1k | T15 | Prothrombin | 3.4.21.5 | 0.445 | |
3d91 | REM | Renin | 3.4.23.15 | 0.445 | |
3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.445 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.445 | |
4kc2 | WS2 | Histo-blood group ABO system transferase | / | 0.445 | |
4klv | KLV | Uncharacterized protein | / | 0.445 | |
6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.444 | |
4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.444 | |
1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.443 | |
2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
3fpz | AHZ | Thiamine thiazole synthase | / | 0.443 | |
3qtv | 06P | Prothrombin | 3.4.21.5 | 0.443 | |
4mlp | 2CX | Cryptochrome-2 | / | 0.443 | |
1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.442 | |
1ghv | 120 | Prothrombin | 3.4.21.5 | 0.442 | |
1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.442 | |
1svg | I04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.442 | |
2flh | ZEA | Cytokinin-specific binding protein | / | 0.442 | |
2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
3dhk | 23U | Prothrombin | 3.4.21.5 | 0.442 | |
3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
3ukf | GDU | UDP-galactopyranose mutase | / | 0.442 | |
4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.442 | |
4yao | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
5kwv | ANP | Pantothenate synthetase | / | 0.442 | |
1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.441 | |
1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.441 | |
2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.441 | |
2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.441 | |
2eeq | SAH | Diphthine synthase | / | 0.441 | |
2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.441 | |
2znk | 31U | Prothrombin | 3.4.21.5 | 0.441 | |
3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.441 | |
3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
4kos | 4KO | Uncharacterized protein | / | 0.441 | |
5dha | GNP | GTP-binding nuclear protein Ran | / | 0.441 | |
1d9i | 00P | Prothrombin | 3.4.21.5 | 0.440 | |
1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.440 | |
1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
1yre | COA | Uncharacterized protein | / | 0.440 | |
2avi | BTN | Avidin | / | 0.440 | |
2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.440 | |
2e15 | SAH | Diphthine synthase | / | 0.440 | |
2ew5 | Y12 | Peptide deformylase | / | 0.440 | |
2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
2zff | 53U | Prothrombin | 3.4.21.5 | 0.440 | |
2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.440 | |
3c27 | DKK | Prothrombin | 3.4.21.5 | 0.440 | |
3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
3eku | CY9 | Actin-5C | / | 0.440 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.440 | |
4a5s | N7F | Dipeptidyl peptidase 4 | / | 0.440 | |
4ccq | NAP | Thioredoxin reductase | / | 0.440 | |
4nmd | FDA | Bifunctional protein PutA | / | 0.440 | |
5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.440 |