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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1txrBESBacterial leucyl aminopeptidase3.4.11.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1txrBESBacterial leucyl aminopeptidase3.4.11.101.000
1xryBESBacterial leucyl aminopeptidase3.4.11.100.735
3h3r14HCollagen type IV alpha-3-binding protein/0.516
3h3qH13Collagen type IV alpha-3-binding protein/0.502
4bb3KKAIsopenicillin N synthase1.21.3.10.499
1r5hAO2Methionine aminopeptidase 2/0.494
3jpuTY4Transcriptional activator protein LasR/0.492
4fxy0W2Neurolysin, mitochondrial3.4.24.160.490
4kovKOVUncharacterized protein/0.489
1ay0TPPTransketolase 12.2.1.10.486
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.486
1w6jR71Lanosterol synthase5.4.99.70.483
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.483
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.481
3h3t16HCollagen type IV alpha-3-binding protein/0.480
3bw4FMNPutative 2-nitropropane dioxygenase/0.479
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
2zhf49UProthrombin3.4.21.50.476
4dk70KSOxysterols receptor LXR-beta/0.476
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
4zu44TGWxcM-like protein/0.476
3dds26BGlycogen phosphorylase, liver form2.4.1.10.474
2aclL05Oxysterols receptor LXR-alpha/0.473
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.473
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
4a802ANMajor pollen allergen Bet v 1-A/0.470
3af0GDPPantothenate kinase2.7.1.330.469
1jwtBLIProthrombin3.4.21.50.468
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3e8xNAPBH1520 protein/0.468
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
1obnASVIsopenicillin N synthase1.21.3.10.467
1r5gAO1Methionine aminopeptidase 2/0.467
1hb1OCVIsopenicillin N synthase1.21.3.10.466
3apwDP0Alpha-1-acid glycoprotein 2/0.466
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
1uxkNADMalate dehydrogenase/0.465
3bgxTMPThymidylate synthase/0.465
5irnADPNucleotide binding oligomerization domain containing 2/0.465
2rqfJH3Hemolymph juvenile hormone binding protein/0.464
3hdyGDUUDP-galactopyranose mutase/0.464
1kqwRTLCellular retinol-binding protein type II/0.463
3oqkS52Renin3.4.23.150.463
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.462
3h0bB35Beta-secretase 13.4.23.460.462
2fbwCBESuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial1.3.5.10.461
2fbwCBESuccinate dehydrogenase cytochrome b, large subunit/0.461
2v13C40Renin3.4.23.150.461
1drhNAPDihydrofolate reductase1.5.1.30.460
1fm4DXCMajor pollen allergen Bet v 1-L/0.460
1nmkSFMPeptidyl-prolyl cis-trans isomerase A5.2.1.80.460
1o5gCR9Prothrombin3.4.21.50.460
2bvs2CEProthrombin3.4.21.50.460
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4an4DUDPutative glycosyl transferase/0.460
4h9tHL4Phosphotriesterase/0.460
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.459
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3zoiM2WIsopenicillin N synthase1.21.3.10.459
1rq1FADEndoplasmic oxidoreductin-11.8.40.458
2y60M8FIsopenicillin N synthase1.21.3.10.458
2zda32UProthrombin3.4.21.50.458
3ix8TX3Transcriptional activator protein LasR/0.458
4jlm1NNDeoxycytidine kinase2.7.1.740.458
1kh3ANPArgininosuccinate synthase/0.457
1tkcM6TTransketolase 12.2.1.10.457
2cmfF11Acetylcholinesterase3.1.1.70.457
2g247IGRenin3.4.23.150.457
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.457
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.457
2pb6SAHDiphthine synthase/0.457
2zdv37UProthrombin3.4.21.50.457
2zfq45UProthrombin3.4.21.50.457
3oiaA31Camphor 5-monooxygenase1.14.15.10.457
1nhpFADNADH peroxidase1.11.1.10.456
2oz57XYUncharacterized protein/0.456
4a6rTA8Probable aminotransferase/0.456
4lzwTHMUridine phosphorylase/0.456
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.455
1zgbA1EAcetylcholinesterase3.1.1.70.455
2zs8ADPPantothenate kinase2.7.1.330.455
3atzFMNProstaglandin F2a synthase/0.455
3f63GTXGlutathione transferase GST1-4/0.455
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.455
3junAKDPhenazine biosynthesis protein A/B/0.455
4kotCE3Uncharacterized protein/0.455
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.455
5dhhDGWNociceptin receptor/0.455
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
1odcA8BAcetylcholinesterase3.1.1.70.454
1ypkCCRProthrombin3.4.21.50.454
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.454
2j9gANPBiotin carboxylase6.3.4.140.454
2vcxD26Hematopoietic prostaglandin D synthase/0.454
3pqbVGPPutative oxidoreductase/0.454
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.454
4a8v2ANMajor pollen allergen Bet v 1-J/0.454
1k5dGNPGTP-binding nuclear protein Ran/0.453
2d1oFA4Stromelysin-13.4.24.170.453
3c1oNAPEugenol synthase/0.453
3h3sH15Collagen type IV alpha-3-binding protein/0.453
3ix4TX1Transcriptional activator protein LasR/0.453
4a862ANMajor pollen allergen Bet v 1-A/0.453
4b63NAPL-ornithine N(5)-monooxygenase/0.453
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
5c1mCLRMu-type opioid receptor/0.453
1gsfEAAGlutathione S-transferase A12.5.1.180.452
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.452
2i4qUA4Renin3.4.23.150.452
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.452
2ym1FADPhenylacetone monooxygenase1.14.13.920.452
2zc922UProthrombin3.4.21.50.452
3gf4UPGUDP-galactopyranose mutase5.4.99.90.452
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.452
2g20L1ARenin3.4.23.150.451
2gvdFKPAdenylate cyclase type 2/0.451
2gvdFKPAdenylate cyclase type 5/0.451
2v16C47Renin3.4.23.150.451
3b1dPLSBetaC-S lyase/0.451
3g0gRUMDipeptidyl peptidase 4/0.451
4ffrATPUncharacterized protein/0.451
4zwgDTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
1w06W05Isopenicillin N synthase1.21.3.10.450
2hxzH7JCathepsin S3.4.22.270.450
2vd0D27Hematopoietic prostaglandin D synthase/0.450
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.450
3p9tTCLRepressor/0.450
2g1a5HGClass B acid phosphatase3.1.3.20.449
2g1r3IGRenin3.4.23.150.449
2gqpPA7Endoplasmin/0.449
2jb4A14Isopenicillin N synthase1.21.3.10.449
2pswCOAN-alpha-acetyltransferase 50/0.449
3af1GDPPantothenate kinase2.7.1.330.449
3q43D66M1 family aminopeptidase3.4.110.449
3tvqDQHMultifunctional cyclase-dehydratase-3-O-methyl transferase TcmN2.1.10.449
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.448
1uzwCDHIsopenicillin N synthase1.21.3.10.448
2emuSAHDiphthine synthase/0.448
2g1o2IGRenin3.4.23.150.448
3bw2FMNPutative 2-nitropropane dioxygenase/0.448
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.448
3w3lRX8Toll-like receptor 8/0.448
3wleNAD(R)-specific carbonyl reductase/0.448
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.448
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.448
5c1gGDUHisto-blood group ABO system transferase/0.448
1gj4132Prothrombin3.4.21.50.447
1mu8CDBProthrombin3.4.21.50.447
1txtCAAHMG-CoA synthase/0.447
1xrpPRO_LEU_GLY_GLYProline iminopeptidase3.4.11.50.447
2r2mI50Prothrombin3.4.21.50.447
4psbGA3Cytokinin-specific binding protein/0.447
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.446
1pq6965Oxysterols receptor LXR-beta/0.446
1szfFMNCytochrome b2, mitochondrial1.1.2.30.446
2ea4F79Methionine aminopeptidase 2/0.446
2emrSAHDiphthine synthase/0.446
2x06NADL-sulfolactate dehydrogenase/0.446
2zevB71Geranylgeranyl pyrophosphate synthase/0.446
3ae4N1MSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial1.3.5.10.446
3ae4N1MSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial/0.446
1lwlDSOCamphor 5-monooxygenase1.14.15.10.445
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2uuk897Prothrombin3.4.21.50.445
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.445
2zhe13UProthrombin3.4.21.50.445
3c1kT15Prothrombin3.4.21.50.445
3d91REMRenin3.4.23.150.445
3g0dXIHDipeptidyl peptidase 4/0.445
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.445
4ax9N5NProthrombin3.4.21.50.445
4kc2WS2Histo-blood group ABO system transferase/0.445
4klvKLVUncharacterized protein/0.445
6stdMS2Scytalone dehydratase4.2.1.940.445
1bk0ACVIsopenicillin N synthase1.21.3.10.444
1eveE20Acetylcholinesterase3.1.1.70.444
1hb3SCVIsopenicillin N synthase1.21.3.10.444
2gv8NDPThiol-specific monooxygenase1.14.130.444
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4er6AW2Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.444
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.444
1s63778Protein farnesyltransferase subunit beta2.5.1.580.443
1xm1GAHProthrombin3.4.21.50.443
2w98P1ZProstaglandin reductase 21.3.1.480.443
3fpzAHZThiamine thiazole synthase/0.443
3qtv06PProthrombin3.4.21.50.443
4mlp2CXCryptochrome-2/0.443
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.442
1ghv120Prothrombin3.4.21.50.442
1nm6L86Prothrombin3.4.21.50.442
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1yw7A41Methionine aminopeptidase 2/0.442
2flhZEACytokinin-specific binding protein/0.442
2iviACWIsopenicillin N synthase1.21.3.10.442
2vbpVB1Isopenicillin N synthase1.21.3.10.442
2znpK55Peroxisome proliferator-activated receptor delta/0.442
3dhk23UProthrombin3.4.21.50.442
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3ukfGDUUDP-galactopyranose mutase/0.442
4a83DXCMajor pollen allergen Bet v 1-A/0.442
4dc0NDPPutative ketoacyl reductase1.3.10.442
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.442
4yaoFADNADPH--cytochrome P450 reductase/0.442
5kwvANPPantothenate synthetase/0.442
1lf2R37Plasmepsin-23.4.23.390.441
1n2gAPCPantothenate synthetase6.3.2.10.441
1tllFADNitric oxide synthase, brain1.14.13.390.441
1zd9GDPADP-ribosylation factor-like protein 8A/0.441
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.441
2cndFADNitrate reductase [NADH]1.7.1.10.441
2d81RB3Poly(3-hydroxybutyrate) depolymerase/0.441
2eeqSAHDiphthine synthase/0.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.441
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
2zi224UProthrombin3.4.21.50.441
2znk31UProthrombin3.4.21.50.441
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3pn4BB2Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.441
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
4kos4KOUncharacterized protein/0.441
5dhaGNPGTP-binding nuclear protein Ran/0.441
1d9i00PProthrombin3.4.21.50.440
1h2bNAJNAD-dependent alcohol dehydrogenase/0.440
1q23FUAChloramphenicol acetyltransferase2.3.1.280.440
1u65CP0Acetylcholinesterase3.1.1.70.440
1xe65FPPlasmepsin-23.4.23.390.440
1yreCOAUncharacterized protein/0.440
2aviBTNAvidin/0.440
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2e15SAHDiphthine synthase/0.440
2ew5Y12Peptide deformylase/0.440
2gyuHI6Acetylcholinesterase3.1.1.70.440
2zff53UProthrombin3.4.21.50.440
2zg050UProthrombin3.4.21.50.440
3c27DKKProthrombin3.4.21.50.440
3c3xNAPEugenol synthase 11.1.1.3180.440
3ekuCY9Actin-5C/0.440
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.440
4a5sN7FDipeptidyl peptidase 4/0.440
4ccqNAPThioredoxin reductase/0.440
4nmdFDABifunctional protein PutA/0.440
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.440