Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tsvUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tsvUMPThymidylate synthase/1.000
2g8aUMPThymidylate synthase/0.704
2tdmUMPThymidylate synthase/0.701
2g86UMPThymidylate synthase/0.646
1njeDCMThymidylate synthase/0.642
1jmhUMPThymidylate synthase/0.628
1bpjUMPThymidylate synthase/0.627
2g89UMPThymidylate synthase/0.614
1jmgUMPThymidylate synthase/0.603
1vzbUMPThymidylate synthase/0.582
1bp6UMPThymidylate synthase/0.579
1njdUMPThymidylate synthase/0.579
1tsxUMPThymidylate synthase/0.575
1tsyUMPThymidylate synthase/0.575
1jmfUMPThymidylate synthase/0.570
1njbUMPThymidylate synthase/0.557
1jmiUMPThymidylate synthase/0.545
1njaDCMThymidylate synthase/0.530
3bgxTMPThymidylate synthase/0.530
1lcbTMPThymidylate synthase/0.518
1bidUMPThymidylate synthase/0.512
1vzaUMPThymidylate synthase/0.509
2g8dUMPThymidylate synthase/0.508
1njcDCMThymidylate synthase/0.487
2vetUMPThymidylate synthase/0.482
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
1aobDDUThymidylate synthase/0.464
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
1bduDURThymidylate synthase/0.461
4dq1UMPThymidylate synthase/0.456
4einNOHThymidylate synthase2.1.1.450.454
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.452
1thyUMPThymidylate synthase/0.449
4iskUMPThymidylate synthase/0.441
1tysTMPThymidylate synthase/0.440