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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tkcM6TTransketolase 12.2.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tkcM6TTransketolase 12.2.1.11.000
1tkbN1TTransketolase 12.2.1.10.693
1ngsTPPTransketolase 12.2.1.10.687
1ay0TPPTransketolase 12.2.1.10.581
2r5nTPPTransketolase 1/0.580
1itzTPPTransketolase, chloroplastic2.2.1.10.578
1tkaN3TTransketolase 12.2.1.10.575
3uptTPPTransketolase/0.565
1trkTPPTransketolase 12.2.1.10.555
3rimTPPTransketolase2.2.1.10.521
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.504
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.493
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.493
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.492
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.463
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.463
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.462
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.461
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.459
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.454
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.450
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.440
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440