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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1th8ADPAnti-sigma F factor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1th8ADPAnti-sigma F factor/1.000
1thnADPAnti-sigma F factor/0.632
1i59ANPChemotaxis protein CheA2.7.13.30.582
1tilATPAnti-sigma F factor/0.548
1i58ADPChemotaxis protein CheA2.7.13.30.546
1i59ADPChemotaxis protein CheA2.7.13.30.545
1i5aACPChemotaxis protein CheA2.7.13.30.532
1i5cADPChemotaxis protein CheA2.7.13.30.530
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.518
1i58ACPChemotaxis protein CheA2.7.13.30.517
1l0oADPAnti-sigma F factor/0.514
3vhaVHAHeat shock protein HSP 90-alpha/0.513
4xivACPChemotaxis protein CheA2.7.13.30.512
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.508
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.506
4r3aANPBlue-light-activated histidine kinase 22.7.13.30.506
4r39ANPBlue-light-activated histidine kinase 22.7.13.30.502
4xivADPChemotaxis protein CheA2.7.13.30.501
3thrC2FGlycine N-methyltransferase2.1.1.200.499
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.498
1nhhANPDNA mismatch repair protein MutL/0.497
1bk0ACVIsopenicillin N synthase1.21.3.10.496
1mx0ANPType 2 DNA topoisomerase 6 subunit B/0.496
2jb4A14Isopenicillin N synthase1.21.3.10.496
4h1e10JBeta-secretase 13.4.23.460.495
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.493
3inxJZCHeat shock protein HSP 90-alpha/0.492
2iorADPChaperone protein HtpG/0.491
4h3g10QBeta-secretase 13.4.23.460.491
4h3j10WBeta-secretase 13.4.23.460.491
2pauD5M5'-deoxynucleotidase YfbR/0.486
4h3f10OBeta-secretase 13.4.23.460.486
2x7hPFNProstaglandin reductase 310.484
2ban357Gag-Pol polyprotein2.7.7.490.483
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.483
4asf62UATP-dependent molecular chaperone HSP82/0.483
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.483
1t4v14AProthrombin3.4.21.50.481
2ejzSAHDiphthine synthase/0.481
3s7a684Dihydrofolate reductase1.5.1.30.481
4dju0KKBeta-secretase 13.4.23.460.481
2bu9HFVIsopenicillin N synthase1.21.3.10.480
3zewSTUEphrin type-B receptor 42.7.10.10.480
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.480
1d6w00RProthrombin3.4.21.50.479
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.479
1am1ADPATP-dependent molecular chaperone HSP82/0.478
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.478
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.478
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.478
1jpaANPEphrin type-B receptor 22.7.10.10.477
1z59ADPType 2 DNA topoisomerase 6 subunit B/0.476
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.476
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.476
4gk3L87Ephrin type-A receptor 32.7.10.10.476
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.476
3s1dZIRCytokinin dehydrogenase 11.5.99.120.475
1t0iFMNNAD(P)H-dependent FMN reductase LOT6/0.474
1uzwCDHIsopenicillin N synthase1.21.3.10.474
2yee2ECHeat shock protein HSP 90-alpha/0.474
3zkyWT4Isopenicillin N synthase1.21.3.10.474
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.474
1hb1OCVIsopenicillin N synthase1.21.3.10.473
1pd9CO4Dihydrofolate reductase1.5.1.30.473
1qiqACCIsopenicillin N synthase1.21.3.10.473
1s3uTQDDihydrofolate reductase1.5.1.30.473
3rlr3RRHeat shock protein HSP 90-alpha/0.473
2iviACWIsopenicillin N synthase1.21.3.10.472
4ivd15TTyrosine-protein kinase JAK1/0.472
1dr3HBIDihydrofolate reductase1.5.1.30.471
1kzjCB3Thymidylate synthase/0.471
2w02ATPAcsD/0.471
3a1l2CCCytochrome P450/0.471
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.471
3hz137DHeat shock protein HSP 90-alpha/0.471
5cc9DDFDihydrofolate reductase1.5.1.30.471
1kceCB3Thymidylate synthase/0.470
2ykcYKCHeat shock protein HSP 90-alpha/0.470
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.470
4gk2L66Ephrin type-A receptor 32.7.10.10.470
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.470
1mvsDTMDihydrofolate reductase1.5.1.30.469
1oc1ASVIsopenicillin N synthase1.21.3.10.469
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.469
2wo7ASVIsopenicillin N synthase1.21.3.10.469
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.469
3clrFADElectron transfer flavoprotein subunit alpha/0.469
4a87NARMajor pollen allergen Bet v 1-A/0.469
4b63NAPL-ornithine N(5)-monooxygenase/0.469
4friDWABeta-secretase 13.4.23.460.469
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.468
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.468
1yplRA8Prothrombin3.4.21.50.467
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.467
2fypRDEEndoplasmin/0.467
2vcmM11Isopenicillin N synthase1.21.3.10.467
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.467
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.467
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.467
1pvgANPDNA topoisomerase 25.99.1.30.466
4h3i10VBeta-secretase 13.4.23.460.466
3qakUKAAdenosine receptor A2a/0.466
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.465
2xw7NDPDihydrofolate reductase/0.465
3nga3NGCasein kinase II subunit alpha2.7.11.10.465
3zoiM2WIsopenicillin N synthase1.21.3.10.465
1db1VDXVitamin D3 receptor/0.464
1dliUDXUDP-glucose 6-dehydrogenase/0.464
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.464
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2p5uNADUDP-glucose 4-epimerase/0.464
3pqbVGPPutative oxidoreductase/0.464
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.464
4djy0KRBeta-secretase 13.4.23.460.464
1byqADPHeat shock protein HSP 90-alpha/0.463
2bbqPFGThymidylate synthase/0.463
2dhfDZFDihydrofolate reductase1.5.1.30.463
2v1aFMNNPH1-1/0.463
4xclAGSHeat shock cognate 90 kDa protein/0.463
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.462
2jh6894Prothrombin3.4.21.50.462
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.462
1f4fTP3Thymidylate synthase/0.461
1ia3TQ5Dihydrofolate reductase1.5.1.30.461
1lkdBP6Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.461
1obnASVIsopenicillin N synthase1.21.3.10.461
2bxqIMNSerum albumin/0.461
2y6fM9FIsopenicillin N synthase1.21.3.10.461
3c11GDMATP-dependent molecular chaperone HSP82/0.461
3wv9FEGHmd co-occurring protein HcgE/0.461
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.461
4jqlVJ6Heat shock protein HSP 90-alpha/0.461
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1tdrMTXDihydrofolate reductase1.5.1.30.460
1tl3H20Gag-Pol polyprotein2.7.7.490.460
1uy9PU6Heat shock protein HSP 90-alpha/0.460
2xvw9NRSerum albumin/0.460
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.460
3v49PK0Androgen receptor/0.460
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4ead0NPThymidine phosphorylase2.4.2.40.460
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1vbiNADMalate/L-lactate dehydrogenase family protein/0.459
1xm1GAHProthrombin3.4.21.50.459
2ea1GPGRibonuclease I3.1.27.60.459
2rabNADGlutathione amide reductase/0.459
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3otwCOAPhosphopantetheine adenylyltransferase/0.459
4udcDEXGlucocorticoid receptor/0.459
1fwmCB3Thymidylate synthase/0.458
1xzqFONtRNA modification GTPase MnmE3.6.50.458
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.458
2w9hTOPDihydrofolate reductase1.5.1.30.458
2xx213CATP-dependent molecular chaperone HSP82/0.458
2ztsADPUncharacterized protein/0.458
3ft8MOJHeat shock protein HSP 90-alpha/0.458
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3ko8NADNAD-dependent epimerase/dehydratase/0.458
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.458
3zdu38RCyclin-dependent kinase-like 32.7.11.220.458
4b78KGGBeta-secretase 13.4.23.460.458
4bqjXKLHeat shock protein HSP 90-alpha/0.458
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.458
4iteTEYVitamin D3 receptor/0.458
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.457
1klkPMDDihydrofolate reductase1.5.1.30.457
1qjfACSIsopenicillin N synthase1.21.3.10.457
1swtBTNStreptavidin/0.457
1uy6PU3Heat shock protein HSP 90-alpha/0.457
1zgv501Prothrombin3.4.21.50.457
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.457
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.457
2y60M8FIsopenicillin N synthase1.21.3.10.457
3biy01KHistone acetyltransferase p300/0.457
3fp0FP015-O-acetyltransferase/0.457
4glx0XSDNA ligase6.5.1.20.457
4ipeANPTNF receptor-associated protein 1/0.457
4jlm1NNDeoxycytidine kinase2.7.1.740.457
4uyf73BBromodomain-containing protein 2/0.457
1bwsNDPGDP-L-fucose synthase/0.456
1diuBDMDihydrofolate reductase1.5.1.30.456
1itzTPPTransketolase, chloroplastic2.2.1.10.456
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2ekaSAHDiphthine synthase/0.456
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.456
2xhrC0PHeat shock protein HSP 90-alpha/0.456
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.456
3w0hW12Vitamin D3 receptor/0.456
4eh5IRGMitogen-activated protein kinase 14/0.456
1ao8MTXDihydrofolate reductase1.5.1.30.455
1fw0KAIGlutamate receptor 2/0.455
2bxoOPBSerum albumin/0.455
3atzFMNProstaglandin F2a synthase/0.455
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.455
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.455
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.455
3qzyFADFAD-linked sulfhydryl oxidase/0.455
4ixgIXGDihydrofolate reductase1.5.1.30.455
1d3dBZTProthrombin3.4.21.50.454
1hb3SCVIsopenicillin N synthase1.21.3.10.454
1jomFFODihydrofolate reductase1.5.1.30.454
1w06W05Isopenicillin N synthase1.21.3.10.454
1w0kADPATP synthase subunit alpha, mitochondrial/0.454
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.454
2cn0F25Prothrombin3.4.21.50.454
2nnlERDDihydroflavonol 4-reductase1.1.1.2190.454
2w03ADNAcsD/0.454
2xviFADPutative flavin-containing monooxygenase/0.454
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3q3cNADNAD-dependent L-serine dehydrogenase/0.454
4a862ANMajor pollen allergen Bet v 1-A/0.454
4bb3KKAIsopenicillin N synthase1.21.3.10.454
4djx0KQBeta-secretase 13.4.23.460.454
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.454
1hfqMOTDihydrofolate reductase1.5.1.30.453
1synF89Thymidylate synthase/0.453
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.453
2xlsFADPutative flavin-containing monooxygenase/0.453
3ctj320Hepatocyte growth factor receptor2.7.10.10.453
3hz142CHeat shock protein HSP 90-alpha/0.453
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3rtnRTNBeta-secretase 13.4.23.460.453
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.453
4alhA9PBromodomain-containing protein 2/0.453
4azy7F3Beta-secretase 13.4.23.460.453
4bj9UHBTankyrase-22.4.2.300.453
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.453
4hni16WCasein kinase I isoform epsilon2.7.11.10.453
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.453
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.453
1dajMOTDihydrofolate reductase1.5.1.30.452
1opbRETRetinol-binding protein 2/0.452
1u71MXADihydrofolate reductase1.5.1.30.452
2aclREARetinoic acid receptor RXR-alpha/0.452
2xyuQ9GEphrin type-A receptor 42.7.10.10.452
3co93MSGenome polyprotein2.7.7.480.452
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.452
4qa0SHHHistone deacetylase 83.5.1.980.452
5dp2NAPCurF/0.452
5uviZMAAdenosine receptor A2a/0.452
1blzACVIsopenicillin N synthase1.21.3.10.451
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.451
1swpBTNStreptavidin/0.451
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2in6839Wee1-like protein kinase2.7.10.20.451
2q8iRDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial2.7.11.20.451
2xabVHDHeat shock protein HSP 90-alpha/0.451
2zhf49UProthrombin3.4.21.50.451
3dogNNNCyclin-dependent kinase 22.7.11.220.451
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3k1wBFXRenin3.4.23.150.451
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.451
3oiaA31Camphor 5-monooxygenase1.14.15.10.451
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4h6rFDAProline dehydrogenase/0.451
4j3mAJ8Tankyrase-22.4.2.300.451
4mv4ACPBiotin carboxylase6.3.4.140.451
1mvtDTMDihydrofolate reductase1.5.1.30.450
1t4u81AProthrombin3.4.21.50.450
2jh0701Prothrombin3.4.21.50.450
2on6IMHPurine nucleoside phosphorylase2.4.2.10.450
2wm3NFLNmrA-like family domain-containing protein 1/0.450
2xcmADPCytosolic heat shock protein 90/0.450
2yegXQGHeat shock protein HSP 90-alpha/0.450
2ykeYKEHeat shock protein HSP 90-alpha/0.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.450
3d74NBBPheromone-binding protein ASP1/0.450
3pxkPXKFocal adhesion kinase 12.7.10.20.450
3uk6ADPRuvB-like 23.6.4.120.450
3vv8B02Beta-secretase 13.4.23.460.450
4b1fKRHGlutamate racemase/0.450
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4fod0UVALK tyrosine kinase receptor2.7.10.10.450
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4qa1B3NHistone deacetylase 83.5.1.980.450
3uzcT4EAdenosine receptor A2a/0.450
1kl2FONSerine hydroxymethyltransferase/0.449
1mu6CDAProthrombin3.4.21.50.449
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.449
2bjsACVIsopenicillin N synthase1.21.3.10.449
2gqpPA7Endoplasmin/0.449
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.449
2iwuNP5ATP-dependent molecular chaperone HSP82/0.449
2nr4FMNConserved protein/0.449
2xpuTDCTetracycline repressor protein class D/0.449
2yeiXQIHeat shock protein HSP 90-alpha/0.449
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.449
3s3vTOPDihydrofolate reductase1.5.1.30.449
3zw9T1GPeroxisomal bifunctional enzyme1.1.1.350.449
4ce2BO5ATP-dependent molecular chaperone HSP82/0.449
4g95OAGDihydrofolate reductase1.5.1.30.449
4wudANPDNA gyrase subunit B/0.449
5iu4ZMAAdenosine receptor A2a/0.449
1dhrNADDihydropteridine reductase1.5.1.340.448
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.448
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.448
1rszDIHPurine nucleoside phosphorylase2.4.2.10.448
1uymPU3Heat shock protein HSP 90-beta/0.448
2h55DZ8Heat shock protein HSP 90-alpha/0.448
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
2wi5ZZ5Heat shock protein HSP 90-alpha/0.448
2wipP49Cyclin-dependent kinase 22.7.11.220.448
3qwbNDPProbable quinone oxidoreductase1.6.5.50.448
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.448
3tydXHPDihydropteroate synthase/0.448
3uleC69Actin-related protein 3/0.448
3zmmF9JTyrosine-protein kinase JAK2/0.448
4b0532DBeta-secretase 13.4.23.460.448
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.448
4i8vBHFCytochrome P450 1A11.14.14.10.448
4o2z046Mitogen-activated protein kinase/0.448
5iua6DXAdenosine receptor A2a/0.448
1dhfFOLDihydrofolate reductase1.5.1.30.447
1ie9VDXVitamin D3 receptor/0.447
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.447
1x8b824Wee1-like protein kinase2.7.10.20.447
2b7aIZATyrosine-protein kinase JAK2/0.447
2bunFADAppA protein/0.447
2ek3SAHDiphthine synthase/0.447
2g8yNADHydroxycarboxylate dehydrogenase B/0.447
2v5aLZLBiotin carboxylase6.3.4.140.447
3drcMTXDihydrofolate reductase1.5.1.30.447
3ekrPY9Heat shock protein HSP 90-alpha/0.447
3p9tTCLRepressor/0.447
3qj0QI3Botulinum neurotoxin type A3.4.24.690.447
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4frkDWDBeta-secretase 13.4.23.460.447
4gk4L90Ephrin type-A receptor 32.7.10.10.447
4ia7BIVVitamin D3 receptor A/0.447
4o74R78Bromodomain-containing protein 4/0.447
4pkl1GHUncharacterized protein/0.447
4qjqOTRLactoperoxidase/0.447
4ryvZEAProtein LlR18A/0.447
4xc0ACPHeat shock cognate 90 kDa protein/0.447
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.447
5g53NECAdenosine receptor A2a/0.447
1mczTDPBenzoylformate decarboxylase4.1.1.70.446
1nm6L86Prothrombin3.4.21.50.446
1w1rZEACytokinin dehydrogenase 11.5.99.120.446
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.446
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
2puiADPMethylthioribose kinase2.7.1.1000.446
2vbdV10Isopenicillin N synthase1.21.3.10.446
2wepADPATP-dependent molecular chaperone HSP82/0.446
2y5s78HDihydropteroate synthase/0.446
3gb4D3MDdmC/0.446
3havATPAminoglycoside phosphotransferase/0.446
3hk1B64Fatty acid-binding protein, adipocyte/0.446
3hyz42CHeat shock protein HSP 90-alpha/0.446
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.446
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.446
4c68NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4dymIYZActivin receptor type-12.7.11.300.446
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4jq3NAPAldo-keto reductase family 1 member C2/0.446
4phlPILPhosphodiesterase/0.446
4twnB96Ephrin type-A receptor 32.7.10.10.446
3emlZMAAdenosine receptor A2a/0.446
1rdtL79Retinoic acid receptor RXR-alpha/0.445
1s1wUC1Gag-Pol polyprotein2.7.7.490.445
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.445
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.445
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.445
2xk2ADPHeat shock protein HSP 90-alpha/0.445
2zfq45UProthrombin3.4.21.50.445
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3k47D09Dihydrofolate reductase1.5.1.30.445
3ln1CELProstaglandin G/H synthase 21.14.99.10.445
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.445
3tm5SFGUncharacterized protein/0.445
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.445
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.445
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.445
4n9iPCGCatabolite expression activator/0.445
4uohADPNucleoside diphosphate kinase/0.445
4x5fFOLDihydrofolate reductase1.5.1.30.445
4xnw2IDP2Y purinoceptor 1/0.445
1a72PADAlcohol dehydrogenase E chain1.1.1.10.444
1axwMTXThymidylate synthase/0.444
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.444
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.444
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
1vruAAPGag-Pol polyprotein2.7.7.490.444
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.444
2byi2DDHeat shock protein HSP 90-alpha/0.444
2egsSAHDiphthine synthase/0.444
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.444
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.444
2pg0FADAcyl-CoA dehydrogenase/0.444
2qujTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.444
2qw034Z4-chlorobenzoyl CoA ligase/0.444
2xvhFADPutative flavin-containing monooxygenase/0.444
2zda32UProthrombin3.4.21.50.444
3aklADPSerine/threonine-protein kinase CtkA2.7.11.10.444
3hz5Z64Heat shock protein HSP 90-alpha/0.444
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4az0S61Lysosomal protective protein3.4.16.50.444
4b0qGMFBeta-secretase 13.4.23.460.444
4dh60KNBeta-secretase 13.4.23.460.444
4eiyZMAAdenosine receptor A2a/0.444
4ewhT77Activated CDC42 kinase 1/0.444
4g8cC6LAlpha/beta hydrolase fold protein/0.444
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.444
4jjiNADAlcohol dehydrogenase class-3/0.444
4mv1ADPBiotin carboxylase6.3.4.140.444
4ng4ADPPhosphoglycerate kinase/0.444
1dr3TAPDihydrofolate reductase1.5.1.30.443
1lb9DNQGlutamate receptor 2/0.443
1trgCB3Thymidylate synthase/0.443
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2fzhDH1Dihydrofolate reductase1.5.1.30.443
2zlcVDXVitamin D3 receptor/0.443
3b1pNOSPfkB carbohydrate kinase family protein/0.443
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3eblGA4Gibberellin receptor GID1/0.443
3fhxPLPPyridoxal kinase2.7.1.350.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
4bfuZVUPantothenate kinase2.7.1.330.443
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.443
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.443
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4m6l21VDihydrofolate reductase1.5.1.30.443
4mk728OGenome polyprotein2.7.7.480.443
1pzhNADLactate dehydrogenase/0.442
1xurPB5Collagenase 33.4.240.442
1ycgFMNNitric oxide reductase10.442
2b56UTPRNA editing complex protein MP57/0.442
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.442
2p2xSAHDiphthine synthase/0.442
3ed1GA3Gibberellin receptor GID1/0.442
3falREARetinoic acid receptor RXR-alpha/0.442
3iedAN2HSP90/0.442
3mcyZH1FimH/0.442
3qwc98PProthrombin3.4.21.50.442
3t10ACPHeat shock protein HSP 90-alpha/0.442
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.442
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.442
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.442
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4ixfIXFDihydrofolate reductase1.5.1.30.442
4p6wMOFGlucocorticoid receptor/0.442
4prvADPDNA gyrase subunit B/0.442
4v12POGMaoC like domain protein/0.442
5a3cNADSIR2 family protein/0.442
5k2dZMAAdenosine receptor A2a/0.442
1ay0TPPTransketolase 12.2.1.10.441
1dg5TOPDihydrofolate reductase1.5.1.30.441
1dg7WRBDihydrofolate reductase1.5.1.30.441
1h74ADPHomoserine kinase2.7.1.390.441
1hvyD16Thymidylate synthase2.1.1.450.441
1muuGDXGDP-mannose 6-dehydrogenase1.1.1.1320.441
1n3sGTPGTP cyclohydrolase 13.5.4.160.441
1tysTMPThymidylate synthase/0.441
2e0nSAHPrecorrin-2 C20-methyltransferase/0.441
2e7rSAHDiphthine synthase/0.441
2eglSAHDiphthine synthase/0.441
2fdwD3GCytochrome P450 2A61.14.130.441
2hamC33Vitamin D3 receptor/0.441
2opqHBQGag-Pol polyprotein2.7.7.490.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2r6jNDPEugenol synthase 11.1.1.3180.441
2w6oOA3Biotin carboxylase6.3.4.140.441
2xszATPRuvB-like 23.6.4.120.441
2xx413IATP-dependent molecular chaperone HSP82/0.441
2yboSAHMethyltransferase/0.441
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3ia4MTXDihydrofolate reductase/0.441
3kq7KQ7Mitogen-activated protein kinase 14/0.441
3maaFKPAdenylate cyclase type 2/0.441
3maaFKPAdenylate cyclase type 5/0.441
3nl6TPSUncharacterized protein/0.441
3wznBTNStreptavidin/0.441
3zep1NXTyrosine-protein kinase JAK32.7.10.20.441
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.441
3zv7NHGAcetylcholinesterase3.1.1.70.441
4b2gV1NUncharacterized protein/0.441
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4c66H4CBromodomain-containing protein 4/0.441
4frjDWBBeta-secretase 13.4.23.460.441
4gevCB3Thymidylate synthase/0.441
4ia1BIVVitamin D3 receptor A/0.441
4kjjFOLDihydrofolate reductase1.5.1.30.441
4lsjLSJGlucocorticoid receptor/0.441
4orkGDPBifunctional AAC/APH2.3.10.441
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.441
4wucANPDNA gyrase subunit B/0.441
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.440
1o97FADElectron transfer flavoprotein subunit alpha/0.440
1s6qTPBGag-Pol polyprotein2.7.7.490.440
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1z71L17Prothrombin3.4.21.50.440
2e08SAHDiphthine synthase/0.440
2gpjFADSiderophore-interacting protein/0.440
2henADPEphrin type-B receptor 22.7.10.10.440
2vagV25Dual specificity protein kinase CLK12.7.12.10.440
2zi53L1Deoxycytidine kinase2.7.1.740.440
2zl9VDAVitamin D3 receptor/0.440
3g70A5TRenin3.4.23.150.440
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.440
3q44D50M1 family aminopeptidase3.4.110.440
3q5kD1UHeat shock protein 83-1/0.440
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4m9aFDAAcyl-CoA dehydrogenase/0.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440
4tjy3GNTankyrase-22.4.2.300.440
4tyj0LIFibroblast growth factor receptor 42.7.10.10.440