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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tdcUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tdcUMPThymidylate synthase/1.000
1bp0UMPThymidylate synthase/0.645
1jmiUMPThymidylate synthase/0.631
1njcDCMThymidylate synthase/0.631
2g8dUMPThymidylate synthase/0.625
1bpjUMPThymidylate synthase/0.605
1jmhUMPThymidylate synthase/0.590
1njaDCMThymidylate synthase/0.588
1tsyUMPThymidylate synthase/0.575
2g89UMPThymidylate synthase/0.575
1lcbTMPThymidylate synthase/0.573
1lcbDHFThymidylate synthase/0.573
1njbUMPThymidylate synthase/0.571
1njeDCMThymidylate synthase/0.571
1bp6UMPThymidylate synthase/0.563
2tdmUMPThymidylate synthase/0.552
1jmgUMPThymidylate synthase/0.548
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.541
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.540
2g86UMPThymidylate synthase/0.534
2vf0F89Thymidylate synthase/0.532
2g8aUMPThymidylate synthase/0.530
1tsvUMPThymidylate synthase/0.527
1tsxUMPThymidylate synthase/0.527
4einNOHThymidylate synthase2.1.1.450.521
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.508
1vzaUMPThymidylate synthase/0.504
1jmfUMPThymidylate synthase/0.500
1njdUMPThymidylate synthase/0.493
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.490
4ez8DHFThymidylate synthase2.1.1.450.488
4e5oUMPThymidylate synthase2.1.1.450.482
4dq1UMPThymidylate synthase/0.473
4eb4UMPThymidylate synthase2.1.1.450.473
4lrrCF9Thymidylate synthase/0.465
4h0uUMPThymidylate synthase/0.464
3qj7UMPThymidylate synthase ThyA/0.462
1f4eTPRThymidylate synthase/0.459
1f28UMPThymidylate synthase2.1.1.450.454
1bidUMPThymidylate synthase/0.446
3bgxTMPThymidylate synthase/0.445
4iskUMPThymidylate synthase/0.444