sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.723 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.696 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.688 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.620 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.594 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.593 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.587 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.550 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.531 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.517 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.516 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.514 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.508 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.506 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.485 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.483 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.478 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.477 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.475 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.474 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.474 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.472 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.471 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.469 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.469 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.468 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.466 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.465 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.462 | |
| 3u9e | COA | Lmo1369 protein | / | 0.461 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.461 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3gob | HXX | DdmC | / | 0.460 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.459 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2y3r | TRK | TamL | / | 0.455 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.453 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.452 | |
| 2y3s | TIR | TamL | / | 0.452 | |
| 3lst | SAH | CalO1 | / | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.452 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.450 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.450 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.449 | |
| 2y4g | TIR | TamL | / | 0.449 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.448 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.448 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1m9r | INE | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.445 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.445 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.445 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.445 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2a1y | 5GP | GMP reductase | / | 0.444 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.444 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.443 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.442 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 3eej | 53R | Uncharacterized protein | / | 0.442 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.442 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.441 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.440 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.440 |