sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1t48 | BB3 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1t48 | BB3 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 1.000 | |
| 3arv | SAU | Chitinase A | / | 0.500 | |
| 4nbl | 2J6 | Caspase-6 | 3.4.22.59 | 0.489 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.481 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.481 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.481 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.478 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
| 4ea0 | 651 | Dehydrosqualene synthase | / | 0.477 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.476 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.476 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.476 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.476 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.476 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.474 | |
| 3bbf | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.474 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.474 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.473 | |
| 3p9t | TCL | Repressor | / | 0.473 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.470 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 4a6d | SAM | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.470 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.469 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.469 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 2gsq | GBI | Glutathione S-transferase | 2.5.1.18 | 0.468 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.467 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.467 | |
| 2jj2 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.466 | |
| 2jj2 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.466 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.465 | |
| 3ba6 | AN2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.465 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.465 | |
| 1y6q | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.464 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.464 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.464 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.463 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2yat | EEU | Estrogen receptor | / | 0.463 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.463 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.462 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.461 | |
| 1uhj | CZB | Aequorin-2 | / | 0.460 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.460 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.459 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.458 | |
| 3q6k | SRO | 43.2 kDa salivary protein | / | 0.458 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.458 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.458 | |
| 1cl2 | PPG | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.457 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.457 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.457 | |
| 4mrx | CZH | Obelin | / | 0.457 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.457 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.456 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.456 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.456 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.456 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3ptz | UDX | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.456 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.455 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.455 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 1e2l | TMC | Thymidine kinase | / | 0.454 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.454 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.454 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4y1b | NAP | AntE | / | 0.453 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 1w19 | T4P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.452 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.452 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.451 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4nbj | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.451 | |
| 4phl | PIL | Phosphodiesterase | / | 0.451 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.451 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.450 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.450 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.450 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.450 | |
| 3qly | 55V | Uncharacterized protein | / | 0.450 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.450 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3c1o | NAP | Eugenol synthase | / | 0.449 | |
| 3iej | 599 | Cathepsin S | 3.4.22.27 | 0.449 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.449 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.449 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.449 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1qv0 | CZH | Obelin | / | 0.448 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.448 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.448 | |
| 3lm4 | HPX | Catechol 2,3-dioxygenase | / | 0.448 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.448 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.448 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.448 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.448 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2bnp | MST | Reaction center protein L chain | / | 0.447 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.447 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 4fsa | 0V3 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.447 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.446 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.446 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.446 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.446 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.446 | |
| 4mry | CEI | Obelin | / | 0.446 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3r58 | NPS | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.445 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4x24 | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.445 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.444 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.444 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.444 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.444 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.444 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.444 | |
| 1w5a | GTP | Cell division protein FtsZ 1 | / | 0.444 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2q6h | CXX | Na(+):neurotransmitter symporter (Snf family) | / | 0.444 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.444 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1jf2 | CZH | Obelin | / | 0.443 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.443 | |
| 1w2c | ANP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 | 0.443 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.443 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.443 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.443 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.443 | |
| 3pdt | ADP | Myosin heavy chain kinase A | 2.7.11.7 | 0.443 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.443 | |
| 3zg6 | APR | NAD-dependent protein deacetylase sirtuin-6 | 3.5.1 | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4c2j | COA | 3-ketoacyl-CoA thiolase, mitochondrial | 2.3.1.16 | 0.443 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 4mub | OAQ | Sulfotransferase oxamniquine resistance protein | / | 0.443 | |
| 4nbn | 2J7 | Caspase-6 | 3.4.22.59 | 0.443 | |
| 4u0k | 744 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ybn | FAD | Flavin-nucleotide-binding protein | / | 0.443 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.442 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3euf | BAU | Uridine phosphorylase 1 | / | 0.442 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.442 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.441 | |
| 2wn6 | NDP | ADP-ribosyltransferase enzymatic component | / | 0.441 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.441 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3u9y | 09L | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.441 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.441 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.440 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.440 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.440 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4jyz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.440 |