scPDB - Distribution of Binding site Similarity values of 1t41 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1t41	ID5	Aldose reductase	1.1.1.21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1t41	ID5	Aldose reductase	1.1.1.21	1.000
1t40	ID5	Aldose reductase	1.1.1.21	0.684
2ikj	393	Aldose reductase	1.1.1.21	0.672
1z89	62P	Aldose reductase	1.1.1.21	0.664
4gca	2X9	Aldose reductase	1.1.1.21	0.663
2pdm	ZST	Aldose reductase	1.1.1.21	0.660
2dv0	ZST	Aldose reductase	1.1.1.21	0.652
2iki	388	Aldose reductase	1.1.1.21	0.649
3m64	393	Aldose reductase	1.1.1.21	0.649
3m4h	388	Aldose reductase	1.1.1.21	0.648
3lql	LDT	Aldose reductase	1.1.1.21	0.644
2fz9	ZST	Aldose reductase	1.1.1.21	0.643
2pdx	ZST	Aldose reductase	1.1.1.21	0.638
2fz8	ZST	Aldose reductase	1.1.1.21	0.637
3t42	3T4	Aldose reductase	1.1.1.21	0.634
2pdp	393	Aldose reductase	1.1.1.21	0.628
1z3n	3NA	Aldose reductase	1.1.1.21	0.626
3lbo	LDT	Aldose reductase	1.1.1.21	0.626
2dux	ZST	Aldose reductase	1.1.1.21	0.621
2hv5	ZST	Aldose reductase	1.1.1.21	0.618
2pdu	393	Aldose reductase	1.1.1.21	0.616
2pdg	47D	Aldose reductase	1.1.1.21	0.612
3ld5	LDT	Aldose reductase	1.1.1.21	0.611
2qxw	LDT	Aldose reductase	1.1.1.21	0.609
2ikh	LIT	Aldose reductase	1.1.1.21	0.605
2pdi	ZST	Aldose reductase	1.1.1.21	0.603
2pdb	ZST	Aldose reductase	1.1.1.21	0.601
2pdh	47D	Aldose reductase	1.1.1.21	0.599
4yu1	53N	Aldose reductase	1.1.1.21	0.598
3mb9	ZST	Aldose reductase	1.1.1.21	0.597
3lz5	LDT	Aldose reductase	1.1.1.21	0.596
2pdf	ZST	Aldose reductase	1.1.1.21	0.595
2pd5	ZST	Aldose reductase	1.1.1.21	0.593
3len	ZST	Aldose reductase	1.1.1.21	0.592
2i17	LDT	Aldose reductase	1.1.1.21	0.585
2i16	LDT	Aldose reductase	1.1.1.21	0.583
3g5e	Q74	Aldose reductase	1.1.1.21	0.582
3ghs	LDT	Aldose reductase	1.1.1.21	0.579
3ghu	LDT	Aldose reductase	1.1.1.21	0.579
3ghr	LDT	Aldose reductase	1.1.1.21	0.577
2hvn	ZST	Aldose reductase	1.1.1.21	0.576
2pdc	393	Aldose reductase	1.1.1.21	0.576
2pdn	47D	Aldose reductase	1.1.1.21	0.576
2duz	ZST	Aldose reductase	1.1.1.21	0.570
3ght	LDT	Aldose reductase	1.1.1.21	0.568
2hvo	ZST	Aldose reductase	1.1.1.21	0.559
1pwl	BFI	Aldose reductase	1.1.1.21	0.553
1iei	ZES	Aldose reductase	1.1.1.21	0.550
1us0	LDT	Aldose reductase	1.1.1.21	0.550
3mc5	393	Aldose reductase	1.1.1.21	0.545
2fzd	TOL	Aldose reductase	1.1.1.21	0.543
2pzn	393	Aldose reductase	1.1.1.21	0.543
3m0i	ZST	Aldose reductase	1.1.1.21	0.541
2pdj	393	Aldose reductase	1.1.1.21	0.539
2pdl	TOL	Aldose reductase	1.1.1.21	0.533
1ah3	TOL	Aldose reductase	1.1.1.21	0.521
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.516
1frb	ZST	Aldose reductase-related protein 2	/	0.509
2pdq	47D	Aldose reductase	1.1.1.21	0.488
2agt	FID	Aldose reductase	1.1.1.21	0.479
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.479
2fzb	TOL	Aldose reductase	1.1.1.21	0.477
3g4k	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.477
1oyn	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.475
3f3y	4OA	Bile salt sulfotransferase	2.8.2.14	0.472
4li6	1XO	Tankyrase-1	2.4.2.30	0.468
1ro6	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.467
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.466
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.462
1el3	I84	Aldose reductase	1.1.1.21	0.460
1eko	I84	Aldose reductase	1.1.1.21	0.459
1kyv	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.459
1tbb	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.459
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.458
4kq6	DLZ	6,7-dimethyl-8-ribityllumazine synthase	/	0.458
1tco	FK5	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.457
1tco	FK5	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	3.1.3.16	0.457
2inz	OHP	Aldose reductase	1.1.1.21	0.456
3g4g	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.456
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.456
4hyf	1AK	Tankyrase-2	2.4.2.30	0.456
4myq	19T	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.455
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.454
1x8l	OXR	Retinol dehydratase	/	0.454
3v94	WYQ	Phosphodiesterase	/	0.454
4u16	3C0	Muscarinic acetylcholine receptor M3	/	0.454
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
2pd9	FID	Aldose reductase	1.1.1.21	0.453
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
4oex	5EO	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.453
1p91	SAM	23S rRNA (guanine(745)-N(1))-methyltransferase	/	0.452
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.452
1s9d	AFB	Cytohesin-2	/	0.451
1s9d	AFB	ADP-ribosylation factor 1	/	0.451
1tfz	869	4-hydroxyphenylpyruvate dioxygenase	1.13.11.27	0.451
2pdw	FID	Aldose reductase	1.1.1.21	0.451
3n3z	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.451
4dbu	BT9	Aldo-keto reductase family 1 member C3	/	0.451
1gjr	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.450
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.450
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.449
4phl	PIL	Phosphodiesterase	/	0.449
2iqd	LPA	Aldose reductase	1.1.1.21	0.448
3uzx	AOM	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.448
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.447
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.447
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.447
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.446
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.446
2xuh	TZ4	Acetylcholinesterase	3.1.1.7	0.446
3p2v	DOY	Aldose reductase	1.1.1.21	0.446
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.444
4hcy	0YN	Transketolase	/	0.444
1xon	PIL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.443
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.443
4li8	1XQ	Tankyrase-1	2.4.2.30	0.443
4lsa	BLD	Protein BRASSINOSTEROID INSENSITIVE 1	2.7.10.1	0.443
5d5a	CAU	Beta-2 adrenergic receptor	/	0.443
1ah0	SBI	Aldose reductase	1.1.1.21	0.441
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.441
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.441
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.441
2rd2	QSI	Glutamine--tRNA ligase	6.1.1.18	0.441
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.441
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.440
2fm0	M98	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
2oaz	I96	Methionine aminopeptidase 2	/	0.440
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.440
4jt9	1NS	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.440
4pab	THG	Dimethylglycine dehydrogenase, mitochondrial	1.5.8.4	0.440