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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1snyNAPLD36273p

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1snyNAPLD36273p/1.000
5idwNAPShort-chain dehydrogenase/reductase SDR/0.555
1n5dNDPCarbonyl reductase [NADPH] 1/0.550
4j7uNAPSepiapterin reductase1.1.1.1530.545
1ae1NAPTropinone reductase 1/0.529
4j7xNAPSepiapterin reductase1.1.1.1530.528
4hwkNAPSepiapterin reductase1.1.1.1530.522
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.521
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.520
1ipeNDPTropinone reductase 21.1.1.2360.516
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.513
1oaaNAPSepiapterin reductase1.1.1.1530.504
4bmvNAPShort-chain dehydrogenase/0.504
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.504
3toxNAPPutative oxidoreductase/0.502
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.501
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.499
4qecNAPElxO/0.498
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.497
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.493
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.492
1xg5NAPDehydrogenase/reductase SDR family member 11/0.492
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.490
4dc1NDPPutative ketoacyl reductase1.3.10.488
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.486
1pr9NAPL-xylulose reductase1.1.1.100.483
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.482
1w4zNAPPutative ketoacyl reductase1.3.10.481
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.478
1x7gNAPPutative ketoacyl reductase1.3.10.477
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.474
1xkqNDPUncharacterized protein/0.474
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.472
2jahNDPClavaldehyde dehydrogenase/0.471
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.469
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.469
3p19NDPPutative blue fluorescent protein/0.468
1g6kNADGlucose 1-dehydrogenase1.1.1.470.466
2bd0NAPSepiapterin reductase/0.465
2dteNAIGlucose 1-dehydrogenase related protein/0.465
2yutNAPPutative short-chain oxidoreductase/0.465
3l77NJPShort-chain alcohol dehydrogenase/0.465
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.462
1wntNAPL-xylulose reductase1.1.1.100.460
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3qrwNDPPutative ketoacyl reductase1.3.10.460
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.460
3sjuNDPKeto reductase/0.459
3gy0NAPNAD(P)-dependent oxidoreductase/0.456
5jlaNADPutative short-chain dehydrogenase/reductase/0.455
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.455
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.454
3f1kNAPUncharacterized oxidoreductase YciK10.454
4esoNAPPutative oxidoreductase/0.453
4qedNAPElxO/0.453
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.452
3d3wNAPL-xylulose reductase1.1.1.100.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.444
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.443
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.443
3tn7NJPShort-chain alcohol dehydrogenase/0.442