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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sn5T3Transthyretin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sn5T3Transthyretin/1.000
1sn0T44Transthyretin/0.684
1ie4T44Transthyretin/0.628
1ictT44Transthyretin/0.548
1tz8DESTransthyretin/0.540
1kgjFL8Transthyretin/0.527
3vt8YI3Vitamin D3 receptor/0.504
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.501
1k6cMK1Gag-Pol polyprotein3.4.23.160.500
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.495
2nnhREACytochrome P450 2C8/0.494
3slkNDPPolyketide synthase extender module 2/0.494
3vt9YI4Vitamin D3 receptor/0.492
3vt7VDXVitamin D3 receptor/0.487
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.486
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.485
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.485
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.482
3zuxTCHTransporter/0.479
4ia2BIVVitamin D3 receptor A/0.478
1knuYPAPeroxisome proliferator-activated receptor gamma/0.477
3vt5YI2Vitamin D3 receptor/0.477
4hee14RPeroxisome proliferator-activated receptor gamma/0.477
5itzLOCTubulin beta-2B chain/0.477
1nvtNAPShikimate dehydrogenase (NADP(+))/0.476
2ca0PXICytochrome P450 monooxygenase PikC/0.476
4g1z0VPVitamin D3 receptor A/0.476
3h0aD30Peroxisome proliferator-activated receptor gamma/0.475
4ia3BIVVitamin D3 receptor A/0.475
4jbiNDPAlcohol dehydrogenase (Zinc)/0.475
4fhi0S4Vitamin D3 receptor A/0.474
2harOCCVitamin D3 receptor/0.473
4nb6444Nuclear receptor ROR-gamma/0.473
2b9wFADPutative aminooxidase/0.472
2q5p241Peroxisome proliferator-activated receptor gamma/0.472
2q61SF1Peroxisome proliferator-activated receptor gamma/0.472
3v9v21LPeroxisome proliferator-activated receptor gamma/0.472
1di8DTQCyclin-dependent kinase 22.7.11.220.471
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.471
4r21STRCytochrome P450 family 17 polypeptide 2/0.471
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.470
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.470
1ybmNAPUncharacterized protein At5g02240/0.469
2ath3EAPeroxisome proliferator-activated receptor gamma/0.469
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.469
4ryvZEAProtein LlR18A/0.469
2hcdBIVVitamin D3 receptor A/0.468
4nxvGDPMitochondrial dynamics protein MID51/0.468
2hb8MVDVitamin D3 receptor/0.467
3syiFADSulfide-quinone reductase/0.467
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.467
4l8u9AZSerum albumin/0.467
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.466
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.465
2rcyNAPPyrroline-5-carboxylate reductase/0.465
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
3jynNDPQuinone oxidoreductase/0.464
3t2yFADSulfide-quinone reductase/0.464
4a6cQG9Gag-Pol polyprotein3.4.23.160.464
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
2bx8AZQSerum albumin/0.463
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.463
3t2zFADSulfide-quinone reductase/0.463
3zuyTCHTransporter/0.463
4b8zNAPGDP-L-fucose synthase1.1.1.2710.463
4g1d0VKVitamin D3 receptor A/0.463
1k6vXN2Gag-Pol polyprotein3.4.23.160.462
3m7rVDXVitamin D3 receptor/0.462
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.462
5br4NADLactaldehyde reductase1.1.1.770.462
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.461
2xlsFADPutative flavin-containing monooxygenase/0.461
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4gyiADPUncharacterized protein/0.461
5e8wSTUTGF-beta receptor type-12.7.11.300.461
1kzjCB3Thymidylate synthase/0.460
2po7CHDFerrochelatase, mitochondrial4.99.1.10.460
2q5g1FAPeroxisome proliferator-activated receptor delta/0.460
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.460
4b7dQLECytochrome P450 monooxygenase PikC/0.460
4xldBRLPeroxisome proliferator-activated receptor gamma/0.460
4xyeNADFormate dehydrogenase/0.460
1jioDEB6-deoxyerythronolide B hydroxylase/0.459
1ppjSMACytochrome b/0.459
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.459
1zhwHC2Oxysterol-binding protein homolog 4/0.459
2y30SM8Putative repressor SimReg2/0.459
3l0lHC3Nuclear receptor ROR-gamma/0.459
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.459
3poz03PEpidermal growth factor receptor2.7.10.10.459
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.459
4cd2FOLDihydrofolate reductase1.5.1.30.459
4nu6NADPhosphonate dehydrogenase1.20.1.10.459
5ifyUMPGlucose-1-phosphate thymidylyltransferase/0.459
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.458
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.458
3i1fGCPTranslation initiation factor 2 subunit gamma/0.458
3kpkFADSulfide-quinone reductase/0.458
3w0hW12Vitamin D3 receptor/0.458
2c6hPXICytochrome P450 monooxygenase PikC/0.457
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3lu8IQXSerum albumin/0.457
4g2h0VQVitamin D3 receptor A/0.457
1fm9570Peroxisome proliferator-activated receptor gamma/0.456
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.456
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.456
2ahrNAPPyrroline-5-carboxylate reductase/0.456
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.456
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.456
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.456
5eypLOCTubulin beta chain/0.456
1k6pXN3Gag-Pol polyprotein3.4.23.160.455
1mabATPATP synthase subunit alpha, mitochondrial/0.455
1uydPU8Heat shock protein HSP 90-alpha/0.455
2q59240Peroxisome proliferator-activated receptor gamma/0.455
3l8sBFFMitogen-activated protein kinase 14/0.455
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.455
4o701QKBromodomain-containing protein 4/0.455
4rupH97Vitamin D3 receptor A/0.455
4tuvCPZCytochrome P450 1191.140.455
4wriOKAOkadaic acid binding protein 2-alpha/0.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1osvCHCBile acid receptor/0.454
1uy7PU4Heat shock protein HSP 90-alpha/0.454
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.454
2hc4VDXVitamin D3 receptor A/0.454
3lu7IPXSerum albumin/0.454
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.454
4fhh0U3Vitamin D3 receptor A/0.454
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4l9q9TPSerum albumin/0.454
4xgxADPFAD:protein FMN transferase/0.454
1e3eNAIAlcohol dehydrogenase 41.1.1.10.453
1phgMYTCamphor 5-monooxygenase1.14.15.10.453
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.453
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
3stw2TDMethylketone synthase I/0.453
3vrwYS5Vitamin D3 receptor/0.453
3w5rLOAVitamin D3 receptor/0.453
4ia1BIVVitamin D3 receptor A/0.453
1kkq471Peroxisome proliferator-activated receptor alpha/0.452
2hasC3OVitamin D3 receptor/0.452
2hb7O1CVitamin D3 receptor/0.452
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.452
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3gc8B45Mitogen-activated protein kinase 112.7.11.240.452
3vtcTK3Vitamin D3 receptor/0.452
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.452
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
4uyf73BBromodomain-containing protein 2/0.452
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.452
1db1VDXVitamin D3 receptor/0.451
1rkhVD2Vitamin D3 receptor/0.451
1xddAAYIntegrin alpha-L/0.451
2gtk208Peroxisome proliferator-activated receptor gamma/0.451
2hbhXE4Vitamin D3 receptor A/0.451
2o4rVD5Vitamin D3 receptor/0.451
3be9P04Casein kinase II subunit alpha2.7.11.10.451
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.451
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.451
4o7uTHFThymidylate synthase/0.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2f1kNAPPrephenate dehydrogenase/0.450
2jn3JN3Fatty acid-binding protein, liver/0.450
2om9AJAPeroxisome proliferator-activated receptor gamma/0.450
2w2lNADD-mandelate dehydrogenase/0.450
2znnS44Peroxisome proliferator-activated receptor alpha/0.450
3ggfGVDSerine/threonine-protein kinase 26/0.450
3t2kFADSulfide-quinone reductase/0.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ia7BIVVitamin D3 receptor A/0.450
1xq6NAPUncharacterized protein At5g02240/0.449
1yb5NAPQuinone oxidoreductase1.6.5.50.449
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.449
3oquA8SAbscisic acid receptor PYL9/0.449
3unk0BYCyclin-dependent kinase 22.7.11.220.449
3vt65YIVitamin D3 receptor/0.449
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.449
4b7sQLECytochrome P450 monooxygenase PikC/0.449
4ele31IDihydrofolate reductase/0.449
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.449
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
2hamC33Vitamin D3 receptor/0.448
2hw2RFPRifampin ADP-ribosyl transferase/0.448
2p33J07Mitogen-activated protein kinase 102.7.11.240.448
2p4yC03Peroxisome proliferator-activated receptor gamma/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.448
2ykjYKJHeat shock protein HSP 90-alpha/0.448
3oroAGSSerine/threonine protein kinase/0.448
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1ie8KH1Vitamin D3 receptor/0.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2iw84SPCyclin-dependent kinase 22.7.11.220.447
2zl9VDAVitamin D3 receptor/0.447
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.447
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
3u4uLNHCasein kinase II subunit alpha2.7.11.10.447
4l9kEHFSerum albumin/0.447
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1nytNAPShikimate dehydrogenase (NADP(+))/0.446
1s0zEB1Vitamin D3 receptor/0.446
1zeoC01Peroxisome proliferator-activated receptor gamma/0.446
2fwyH64Heat shock protein HSP 90-alpha/0.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.446
2vzmNRBCytochrome P450 monooxygenase PikC/0.446
2wotZZGTGF-beta receptor type-12.7.11.300.446
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3t14FADSulfide-quinone reductase/0.446
3twoNDPMannitol dehydrogenase/0.446
3wowANPCasein kinase II subunit alpha2.7.11.10.446
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
5bsgNAPPyrroline-5-carboxylate reductase/0.446
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.445
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.445
1ysx4EBSerum albumin/0.445
2c7xNRBCytochrome P450 monooxygenase PikC/0.445
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.445
2zlcVDXVitamin D3 receptor/0.445
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.445
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.445
3stuDK3Methylketone synthase I/0.445
4k2xFADPolyketide oxygenase/hydroxylase/0.445
4ysjADPCalmodulin-like domain protein kinase/0.445
1k74544Peroxisome proliferator-activated receptor gamma/0.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.444
1w8cN69Cyclin-dependent kinase 22.7.11.220.444
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.444
3mqe416Prostaglandin G/H synthase 21.14.99.10.444
3vt45YIVitamin D3 receptor/0.444
3wd7COAAcridone synthase/0.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.444
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.444
4i02CMPcAMP-activated global transcriptional regulator CRP/0.444
4iaq2GM5-hydroxytryptamine receptor 1B/0.444
4lxhC1EAlpha/beta hydrolase fold/0.444
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.444
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.443
1iyzNDPProbable quinone oxidoreductase/0.443
1nq7ARLNuclear receptor ROR-beta/0.443
1tlcF89Thymidylate synthase/0.443
1uyfPU1Heat shock protein HSP 90-alpha/0.443
2cduFADNADH oxidase/0.443
2y03Y01Beta-1 adrenergic receptor/0.443
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.443
3h0sB38Acetyl-CoA carboxylase/0.443
3kpzZNEVitamin D3 receptor/0.443
3tk3CPZCytochrome P450 2B41.14.14.10.443
3vtbTKAVitamin D3 receptor/0.443
3wxyCOAUncharacterized protein/0.443
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4dymIYZActivin receptor type-12.7.11.300.443
4f9fGDPPutative glycosyltransferase/0.443
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4g1y0VOVitamin D3 receptor A/0.443
4kbk1QGCasein kinase I isoform delta2.7.11.10.443
4kvxACON-terminal acetyltransferase A complex catalytic subunit ard12.3.1.880.443
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
1ewyFADFerredoxin--NADP reductase1.18.1.20.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1m17AQ4Epidermal growth factor receptor2.7.10.10.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.442
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
2xviFADPutative flavin-containing monooxygenase/0.442
3eek53SUncharacterized protein/0.442
3mnrSD1Heat shock protein HSP 90-alpha/0.442
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
3tdaPN0Cytochrome P450 2D6/0.442
3tqhNDPQuinone oxidoreductase/0.442
3vtdTKDVitamin D3 receptor/0.442
4g20484Vitamin D3 receptor A/0.442
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.442
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.442
4o2bLOCTubulin beta-2B chain/0.442
4q0a4OAVitamin D3 receptor A/0.442
1d7lRFLp-hydroxybenzoate hydroxylase/0.441
1oc1ASVIsopenicillin N synthase1.21.3.10.441
1rkgVD1Vitamin D3 receptor/0.441
2j14GNIPeroxisome proliferator-activated receptor delta/0.441
2vf0F89Thymidylate synthase/0.441
2zlaVDBVitamin D3 receptor/0.441
3axwTIDCasein kinase II subunit alpha2.7.11.10.441
3clyACPFibroblast growth factor receptor 2/0.441
3crzFADFerredoxin--NADP+ reductase/0.441
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.441
3d8bADPFidgetin-like protein 13.6.40.441
3gw9VNILanosterol 14-alpha-demethylase/0.441
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.441
4ez50RSCyclin-dependent kinase 62.7.11.220.441
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
4nh82LCHeat shock protein HSP 90-alpha/0.441
4ubsDIFPentalenic acid synthase1.14.15.110.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.440
1kijNOVDNA gyrase subunit B/0.440
1qxoFMNChorismate synthase/0.440
1zhzERGOxysterol-binding protein homolog 4/0.440
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.440
2jd0NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
2q8sL92Peroxisome proliferator-activated receptor gamma/0.440
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.440
2znoS44Peroxisome proliferator-activated receptor gamma/0.440
3a1l2CCCytochrome P450/0.440
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
3tvuB37Acetyl-CoA carboxylase/0.440
3zk5Z18Cytochrome P450 monooxygenase PikC/0.440
4anmWULCasein kinase II subunit alpha2.7.11.10.440
4ez8DHFThymidylate synthase2.1.1.450.440
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.440
4j6dTESCytochrome P450 monooxygenase/0.440
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440
4ruoBIVVitamin D3 receptor A/0.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
4z9g1Q5Corticotropin-releasing factor receptor 1/0.440