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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sm4FADFerredoxin--NADP reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sm4FADFerredoxin--NADP reductase/1.000
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.656
3vo2FADFerredoxin--NADP reductase/0.636
3zc3FADFerredoxin--NADP reductase1.18.1.20.626
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.622
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.617
1gaqFADFerredoxin/0.614
1gawFADFerredoxin/0.613
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.609
1gjrFADFerredoxin--NADP reductase1.18.1.20.608
1h42FADFerredoxin--NADP reductase1.18.1.20.597
2b5oFADFerredoxin--NADP reductase1.18.1.20.595
1bjkFADFerredoxin--NADP reductase1.18.1.20.594
1e64FADFerredoxin--NADP reductase1.18.1.20.591
3w5uFADFerredoxin/0.591
1go2FADFerredoxin--NADP reductase1.18.1.20.590
3zbtFADFerredoxin--NADP reductase1.18.1.20.590
1w35FADFerredoxin--NADP reductase1.18.1.20.589
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.587
1qgyFADFerredoxin--NADP reductase1.18.1.20.586
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.581
2rc6FADFerredoxin--NADP reductase/0.575
1qh0FADFerredoxin--NADP reductase1.18.1.20.572
1w87FADFerredoxin--NADP reductase1.18.1.20.571
4bprFADFerredoxin--NADP reductase1.18.1.20.567
1h85FADFerredoxin--NADP reductase1.18.1.20.566
3fpkFADFerredoxin-NADP reductase/0.562
1queFADFerredoxin--NADP reductase1.18.1.20.560
4c43FADFerredoxin--NADP reductase1.18.1.20.558
1ewyFADFerredoxin--NADP reductase1.18.1.20.554
1e62FADFerredoxin--NADP reductase1.18.1.20.550
4y9uFADNADPH--cytochrome P450 reductase/0.548
2ok8FADFerredoxin--NADP reductase, apicoplast/0.545
1ogiFADFerredoxin--NADP reductase1.18.1.20.541
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.539
1e63FADFerredoxin--NADP reductase1.18.1.20.537
1b2rFADFerredoxin--NADP reductase1.18.1.20.528
3qfsFADNADPH--cytochrome P450 reductase/0.524
1amoFADNADPH--cytochrome P450 reductase/0.523
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.523
1ogjFADFerredoxin--NADP reductase1.18.1.20.523
3qftFADNADPH--cytochrome P450 reductase/0.518
1gr1FADFerredoxin--NADP reductase1.18.1.20.517
4y7cFADNADPH--cytochrome P450 reductase/0.517
3qe2FADNADPH--cytochrome P450 reductase/0.516
2rc5FADFerredoxin--NADP reductase/0.512
1qgzFADFerredoxin--NADP reductase1.18.1.20.510
4yaoFADNADPH--cytochrome P450 reductase/0.509
1tllFADNitric oxide synthase, brain1.14.13.390.507
3qfcFADNADPH--cytochrome P450 reductase/0.507
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.506
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.505
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.504
4yafFADNADPH--cytochrome P450 reductase/0.504
3jqrFADFerredoxin--NADP reductase, apicoplast/0.501
2bpoFADNADPH--cytochrome P450 reductase/0.496
1gvhFADFlavohemoprotein/0.495
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.493
3ojxFADNADPH--cytochrome P450 reductase/0.493
4y9rFADNADPH--cytochrome P450 reductase/0.493
1j9zFADNADPH--cytochrome P450 reductase/0.490
5a4vQUEGlutathione S-transferase F22.5.1.180.487
1ja1FADNADPH--cytochrome P450 reductase/0.483
1cqxFADFlavohemoprotein/0.479
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.478
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.475
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.468
1r5hAO2Methionine aminopeptidase 2/0.467
1f20FADNitric oxide synthase, brain1.14.13.390.466
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.466
2bf4FADNADPH--cytochrome P450 reductase/0.465
5a4wQCTGlutathione S-transferase F22.5.1.180.465
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.463
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.463
1x1bSAHC-20 methyltransferase/0.463
2bu9HFVIsopenicillin N synthase1.21.3.10.462
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.462
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.461
1pqc444Oxysterols receptor LXR-beta/0.460
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.459
3kp4MIITranscriptional regulator TcaR/0.459
4bfvZVVPantothenate kinase2.7.1.330.459
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.458
4q0kGA3Phytohormone-binding protein/0.458
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.457
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3wqmB29Diterpene synthase3.1.7.80.457
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.456
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.456
4jlj1NMDeoxycytidine kinase2.7.1.740.456
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.455
2iviACWIsopenicillin N synthase1.21.3.10.454
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.454
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.454
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.454
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2ejzSAHDiphthine synthase/0.453
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
1fdrFADFerredoxin--NADP reductase1.18.1.20.452
1g6oADPCag alpha/0.452
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
3ihgVAKAklavinone 12-hydroxylase RdmE/0.452
4bfsZVSPantothenate kinase2.7.1.330.452
1ndzFR5Adenosine deaminase3.5.4.40.451
2y6fM9FIsopenicillin N synthase1.21.3.10.451
3iktNADRedox-sensing transcriptional repressor Rex/0.450
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3gusN11Glutathione S-transferase P2.5.1.180.449
2ed3SAHDiphthine synthase/0.448
1qzyTDEMethionine aminopeptidase 2/0.447
1x1dSAHC-20 methyltransferase/0.447
2cmfF11Acetylcholinesterase3.1.1.70.447
2geuCOKPantothenate kinase2.7.1.330.447
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.447
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.447
1ptjNAPNAD(P) transhydrogenase subunit beta1.6.1.20.446
1s9dAFBCytohesin-2/0.446
1s9dAFBADP-ribosylation factor 1/0.446
1x1cSAHC-20 methyltransferase/0.446
1xddAAYIntegrin alpha-L/0.446
2xysSY9Soluble acetylcholine receptor/0.446
4h1e10JBeta-secretase 13.4.23.460.446
1hb1OCVIsopenicillin N synthase1.21.3.10.445
1jqdSAHHistamine N-methyltransferase2.1.1.80.445
1pq944BOxysterols receptor LXR-beta/0.445
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.445
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.445
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.445
1dgfNDPCatalase1.11.1.60.444
1tilATPAnti-sigma F factor/0.444
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3ojwFMNNADPH--cytochrome P450 reductase/0.444
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
4b65FADL-ornithine N(5)-monooxygenase/0.444
4x28FDAAcyl-CoA dehydrogenase FadE26/0.444
4x28FDAAcyl-CoA dehydrogenase FadE27/0.444
1thnADPAnti-sigma F factor/0.443
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.443
2piaFMNPhthalate dioxygenase reductase/0.442
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.442
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2gevCOKPantothenate kinase2.7.1.330.441
2gpjFADSiderophore-interacting protein/0.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
3dr7GPDGDP-perosamine synthase/0.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
4bftZVTPantothenate kinase2.7.1.330.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.440
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3rsv3RSBeta-secretase 13.4.23.460.440
4yauFADNADPH--cytochrome P450 reductase/0.440