Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.21.000
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.537
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.515
3r9dX6BCyclin-dependent kinase 22.7.11.220.503
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.498
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.487
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
4erwSTUCyclin-dependent kinase 22.7.11.220.481
1aq1STUCyclin-dependent kinase 22.7.11.220.471
4nj32KDCyclin-dependent kinase 22.7.11.220.467
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
2c6eHPMAurora kinase A2.7.11.10.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.457
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.448
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.446
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2vu3LZECyclin-dependent kinase 22.7.11.220.445
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.444
3zewSTUEphrin type-B receptor 42.7.10.10.442
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.441