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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.581.000
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.654
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.651
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.648
1s63778Protein farnesyltransferase subunit beta2.5.1.580.646
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.642
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.630
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.626
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.623
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.614
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.610
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.586
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.581
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.570
3sfy3FYUncharacterized protein/0.567
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.566
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.553
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.553
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.546
3q7fED2Uncharacterized protein/0.528
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.508
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.505
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.495
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.495
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.493
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.488
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.478
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.476
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.447
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.445
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.445
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.444
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.440