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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s9qOHTEstrogen-related receptor gamma

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s9qOHTEstrogen-related receptor gamma/1.000
2gpvOHTEstrogen-related receptor gamma/0.646
2p7zOHTEstrogen-related receptor gamma/0.618
2gpuOHTEstrogen-related receptor gamma/0.574
2ewpTXFEstrogen-related receptor gamma/0.542
1s9pDESEstrogen-related receptor gamma/0.534
1errRALEstrogen receptor/0.512
1yinCM3Estrogen receptor/0.510
2ovmAS0Progesterone receptor/0.506
4ia7BIVVitamin D3 receptor A/0.502
2ovhAS0Progesterone receptor/0.500
3d90NOGProgesterone receptor/0.491
4ia1BIVVitamin D3 receptor A/0.490
4ia3BIVVitamin D3 receptor A/0.489
4ia2BIVVitamin D3 receptor A/0.487
2qe4JJ3Estrogen receptor/0.486
4a2jAS0Progesterone receptor/0.486
1nhz486Glucocorticoid receptor/0.484
1qknRALEstrogen receptor beta/0.484
2jf9OHTEstrogen receptor/0.479
2jfaRALEstrogen receptor/0.479
4em9TCEPeroxisome proliferator-activated receptor gamma/0.479
2bj4OHTEstrogen receptor/0.478
2hcdBIVVitamin D3 receptor A/0.473
1xqcAEJEstrogen receptor/0.472
1gs4ZK5Androgen receptor/0.471
4lsjLSJGlucocorticoid receptor/0.468
4nc3ERM5-hydroxytryptamine receptor 2B/0.464
4ruoBIVVitamin D3 receptor A/0.463
1ndeMONEstrogen receptor beta/0.461
1sj0E4DEstrogen receptor/0.461
4bchT7ZCyclin-dependent kinase 92.7.11.220.460
1uomPTIEstrogen receptor/0.459
2w8yNDRProgesterone receptor/0.459
2ab2SNLMineralocorticoid receptor/0.458
2qjpSMACytochrome b/0.458
2x7gPVBSRSF protein kinase 22.7.11.10.458
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
1fbyREARetinoic acid receptor RXR-alpha/0.457
1xp6AIUEstrogen receptor/0.457
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.457
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.457
1og5SWFCytochrome P450 2C9/0.456
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.456
2pixDHTAndrogen receptor/0.456
3h4vDVPPteridine reductase 11.5.1.330.456
3u8hBHPPhospholipase A2, membrane associated/0.456
4apuOR8Progesterone receptor/0.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.455
4jlj1NMDeoxycytidine kinase2.7.1.740.455
2aaxPDNMineralocorticoid receptor/0.454
2bf7HBIPteridine reductase 11.5.1.330.454
3cseN22Uncharacterized protein/0.454
3eek53SUncharacterized protein/0.454
4ipw1G7Mycocyclosin synthase1.14.21.90.454
4rupH97Vitamin D3 receptor A/0.454
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
2w8y486Progesterone receptor/0.453
3zrbOR8Progesterone receptor/0.453
5uviZMAAdenosine receptor A2a/0.453
1m7aMQUDihydrofolate reductase1.5.1.30.452
1yqj6NPMitogen-activated protein kinase 14/0.452
3qlhT27Gag-Pol polyprotein2.7.7.490.452
2amb17HAndrogen receptor/0.451
2fziDH3Dihydrofolate reductase1.5.1.30.451
3uvvREARetinoic acid receptor RXR-alpha/0.451
1mznBM6Retinoic acid receptor RXR-alpha/0.450
1rdtL79Retinoic acid receptor RXR-alpha/0.450
2q6sPLBPeroxisome proliferator-activated receptor gamma/0.450
3new3NEMitogen-activated protein kinase 14/0.450
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.450
1rkhVD2Vitamin D3 receptor/0.449
3a783EVVitamin D3 receptor/0.449
3negPYVAbscisic acid receptor PYL1/0.449
4iah1DXAlr2278 protein/0.449
2pivDHTAndrogen receptor/0.448
4apuA2KProgesterone receptor/0.448
4rw6494Gag-Pol polyprotein2.7.7.490.448
1fmlRTLRetinol dehydratase/0.447
1l2jETCEstrogen receptor beta/0.447
3bl7DD1m7GpppX diphosphatase3.6.1.590.447
3cv9VDXVitamin D3 dihydroxylase/0.447
1ppjANYCytochrome b/0.446
2bfmTOPPteridine reductase 11.5.1.330.446
3zraORBProgesterone receptor/0.446
2jedLG8Protein kinase C theta type2.7.11.130.445
3dl9V2HVitamin D 25-hydroxylase/0.445
3w5p4OAVitamin D3 receptor/0.445
3zrbORCProgesterone receptor/0.445
4nieNBHNuclear receptor ROR-gamma/0.445
1fm69CRRetinoic acid receptor RXR-alpha/0.444
1ia3TQ5Dihydrofolate reductase1.5.1.30.444
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
2fszOHTEstrogen receptor beta/0.444
4k4eK4ETankyrase-12.4.2.300.444
1xj7DHTAndrogen receptor/0.443
2aclREARetinoic acid receptor RXR-alpha/0.443
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3zr7OR8Progesterone receptor/0.443
4h9506UDihydrofolate reductase1.5.1.30.443
2pnuENMAndrogen receptor/0.442
3vrwYS5Vitamin D3 receptor/0.442
3vt7VDXVitamin D3 receptor/0.442
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.442
4cd2FOLDihydrofolate reductase1.5.1.30.442
4g1d0VKVitamin D3 receptor A/0.442
4h9614QDihydrofolate reductase1.5.1.30.442
1k749CRRetinoic acid receptor RXR-alpha/0.441
1uhlMEIRetinoic acid receptor RXR-beta/0.441
1wxyFRKAdenosine deaminase3.5.4.40.441
2oaxSNLMineralocorticoid receptor/0.441
2vzmNRBCytochrome P450 monooxygenase PikC/0.441
3gwfFADCyclohexanone monooxygenase/0.441
3oqkS52Renin3.4.23.150.441
4iarERM5-hydroxytryptamine receptor 1B/0.441
5k2bZMAAdenosine receptor A2a/0.441
1aoeGW3Dihydrofolate reductase1.5.1.30.440
1blzACVIsopenicillin N synthase1.21.3.10.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
3vt8YI3Vitamin D3 receptor/0.440
3w0aDS5Vitamin D3 receptor/0.440
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4iw8KN3Estrogen receptor/0.440
4rw4494Gag-Pol polyprotein2.7.7.490.440
3pwhZMAAdenosine receptor A2a/0.440