scPDB - Distribution of Binding site Similarity values of 1s3u entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1s3u	TQD	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	1.000
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.687
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.626
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.597
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.579
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.571
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.569
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.554
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.547
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.525
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.523
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.511
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.511
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.506
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.504
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.482
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.481
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.472
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.466
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.462
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.459
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.455
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.453
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.452
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.452
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.449
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.447
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.445
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.445
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.445
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.444
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.442
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.442
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.441
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.441
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.441