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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s1cGNPTransforming protein RhoA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s1cGNPTransforming protein RhoA/1.000
2gcpGSPRho-related GTP-binding protein RhoC/0.623
1kmqGNPTransforming protein RhoA/0.620
1a2bGSPTransforming protein RhoA/0.597
3a58GNPGTP-binding protein RHO1/0.588
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.581
1cxzGSPTransforming protein RhoA/0.580
4js0GNPCell division control protein 42 homolog/0.577
3th5GNPRas-related C3 botulinum toxin substrate 1/0.575
1e96GTPRas-related C3 botulinum toxin substrate 1/0.574
3kz1GSPTransforming protein RhoA/0.569
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.566
5hpyGDPTransforming protein RhoA/0.565
3eg5GNPCell division control protein 42 homolog/0.564
1z2cGNPRho-related GTP-binding protein RhoC/0.562
4rkfGNPRas-related protein Rab-3/0.558
1m7bGTPRho-related GTP-binding protein RhoE/0.556
3e5hGNPRas-related protein Rab-28/0.555
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.552
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.552
1xtsGTPGTP-binding protein Rheb/0.550
1yhnGTPRas-related protein Rab-7a/0.550
4xoiGTPTransforming protein RhoA/0.545
5dhaGNPGTP-binding nuclear protein Ran/0.540
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.537
4o25GTPGTP-binding protein Rheb/0.535
4kvgGTPRas-related protein Rap-1A/0.534
4mitGTPRho-related protein racC/0.533
1zc4GNPRas-related protein Ral-A/0.526
1xtrGNPGTP-binding protein Rheb/0.525
2gilGTPRas-related protein Rab-6A/0.524
2bkuGTPGTP-binding nuclear protein Ran/0.523
3a6pGTPGTP-binding nuclear protein Ran/0.523
2clsGTPRho-related GTP-binding protein Rho6/0.522
3bbpGTPRas-related protein Rab-6A/0.521
4nyiGNPGTPase HRas/0.518
1k5dGNPGTP-binding nuclear protein Ran/0.517
3w3zGTPGTP-binding nuclear protein Ran/0.516
5jljGNPGTP-binding nuclear protein Ran/0.516
2c5lGTPGTPase HRas/0.514
2zetGTPRas-related protein Rab-27B/0.514
1zbdGTPRas-related protein Rab-3A/0.512
4nyjGNPGTPase HRas/0.512
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.511
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.511
3tsoGNPRas-related protein Rab-25/0.510
1t91GTPRas-related protein Rab-7a/0.507
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.507
3kucGDPRas-related protein Rap-1A/0.507
1ow3GDPTransforming protein RhoA/0.506
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.505
1ibrGNPGTP-binding nuclear protein Ran/0.504
1vg8GNPRas-related protein Rab-7a/0.504
4qxaGTPRas-related protein Rab-9A/0.502
1yzqGNPRas-related protein Rab-6A/0.499
1zc3GNPRas-related protein Ral-A/0.498
3ea5GDPGTP-binding nuclear protein Ran/0.497
3rs5GNPGTPase HRas/0.494
1gwnGTPRho-related GTP-binding protein RhoE/0.493
2ffqGSPRas-related protein Rab-6B/0.493
1g17GNPRas-related protein SEC4/0.492
3rabGNPRas-related protein Rab-3A/0.492
3i3sGNPGTPase HRas/0.491
3lbnGNPGTPase HRas/0.491
3oesGNPGTPase RhebL1/0.491
3tgpGNPGTPase HRas/0.488
4oi2ADPProtein clpf-1/0.486
3l8yGNPGTPase HRas/0.485
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.484
3ddcGNPGTPase HRas/0.484
3lawGNPRas-related protein Rab-7a/0.484
4dltGNPGTPase HRas/0.484
5b2zGNPGTPase HRas/0.483
3bc1GNPRas-related protein Rab-27A/0.481
3tnfGNPRas-related protein Rab-8A/0.481
4cymGCPRas-related protein Rab-32/0.481
4dvgGSPRho family GTPase/0.481
3oiuGNPGTPase HRas/0.478
3v4fGNPGTPase HRas/0.478
4dsnGCPGTPase KRas/0.476
4ol0GTPGTP-binding nuclear protein Ran/0.476
2fe4GDPRas-related protein Rab-6B/0.474
4hdoGNPRas-related protein Rap-1b/0.473
4lhwGNPRas-related protein Rab-8A/0.472
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.471
3kudGDPGTPase HRas/0.471
3tklGTPRas-related protein Rab-1A/0.471
4g0nGNPGTPase HRas/0.470
3oivGNPGTPase HRas/0.469
3kkoGNPRas-related protein M-Ras/0.468
3lbhGNPGTPase HRas/0.467
4dxaGSPRas-related protein Rap-1b/0.467
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.466
4dlwGNPGTPase HRas/0.466
1w5tANPORC1-type DNA replication protein 2/0.464
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.464
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.464
1lfdGNPGTPase HRas/0.463
2rgbGNPGTPase HRas/0.463
3rs4GNPGTPase HRas/0.460
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.459
1oixGDPRas-related protein Rab-11A/0.459
3oiwGNPGTPase HRas/0.459
2rgcGNPGTPase HRas/0.458
2rgeGNPGTPase HRas/0.458
3rs7GNPGTPase HRas/0.458
1uadGNPRas-related protein Ral-A/0.457
4hdqGNPRas-related protein Rap-1b/0.457
3qbtGNPRas-related protein Rab-8A/0.454
5c46GSPRas-related protein Rab-11A/0.453
2po7CHDFerrochelatase, mitochondrial4.99.1.10.452
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.452
2j0vGDPRac-like GTP-binding protein ARAC7/0.451
1vdcFADThioredoxin reductase 1, mitochondrial1.8.1.90.449
2cl6CAGGTPase HRas/0.449
4ohwATPProtein clpf-1/0.449
4uj3GNPRas-related protein Rab-11A/0.449
3adaNADSubunit alpha of sarocosine oxidase/0.448
1dvrATFAdenylate kinase/0.447
1zd9GDPADP-ribosylation factor-like protein 8A/0.447
3lbiGNPGTPase HRas/0.447
3wyfGTPGTP-binding nuclear protein/0.447
1w5sADPORC1-type DNA replication protein 2/0.446
3kkqGDPRas-related protein M-Ras/0.446
4dsoGSPGTPase KRas/0.446
4tq9GDPGTPase KRas/0.446
1cbrREACellular retinoic acid-binding protein 1/0.445
1e4yAP5Adenylate kinase/0.442
4mvcCDCCholine-phosphate cytidylyltransferase A/0.442
4obeGDPGTPase KRas/0.442
5difGNPGTP-binding nuclear protein Ran/0.442
5bn3ADPV-type ATP synthase alpha chain/0.440
5bn3ADPNEQ263/0.440